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Literature DB >> 3097249

Possible melatonin involvement in the hypotensive effect of MAO inhibitors.

G F Oxenkrug, R B McCauley, D J Fontana, I M McIntyre, R L Commissaris.

Abstract

Effect of selective inhibitors of MAO-A and B isoenzymes on pineal melatonin (and related indoles), arterial blood pressure and brain MAO-A and B activities has been evaluated in intact, pinealectomized and sham-operated rats. Selective inhibition of MAO-A but not MAO-B activity stimulated pineal melatonin synthesis and decreased arterial blood pressure in intact and sham-operated animals. Pinealectomy attenuated the hypotensive effect of MAO-A inhibition. The possible melatonin contribution to both antidepressive and hypotensive effects of MAO inhibitors is discussed.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 3097249 DOI： 10.1007/bf01260919

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

15 in total

1. A HYPERTENSIVE SYNDROME WITH TRANYLCYPROMINE MEDICATION.

Authors: A J COOPER; R V MAGNUS; M J ROSE
Journal: Lancet Date: 1964-03-07 Impact factor: 79.321

2. "FALSE NEUROCHEMICAL TRANSMITTERS" AND THE MECHANISM OF SYMPATHETIC BLOCKADE BY MONOAMINE OXIDASE INHIBITORS.

Authors: I J KOPIN; J E FISCHER; J M MUSACCHIO; W D HORST; V K WEISE
Journal: J Pharmacol Exp Ther Date: 1965-02 Impact factor: 4.030

3. Isoprotenerol induction of pineal serotonin N-acetyltransferase in normotensive and spontaneously hypertensive rats.

Authors: H Illnerová; I Ablrecht
Journal: Experientia Date: 1975-01-15

4. Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.

Authors: S W Holmes; D Sugden
Journal: Br J Pharmacol Date: 1976-03 Impact factor: 8.739

5. Noradrenaline: central inhibitory control of blood pressure and heart rate.

Authors: W De Jong
Journal: Eur J Pharmacol Date: 1974-11 Impact factor: 4.432

6. Effects of rats of pinealectomy and oxypertine on spontaneous locomotor activity and blood pressure during various light schedules.

Authors: H Karppanen; M M Airaksinen; I Särkimäki
Journal: Ann Med Exp Biol Fenn Date: 1973-03

Possible melatonin involvement in the hypotensive effect of MAO inhibitors.

1. A HYPERTENSIVE SYNDROME WITH TRANYLCYPROMINE MEDICATION.

2. "FALSE NEUROCHEMICAL TRANSMITTERS" AND THE MECHANISM OF SYMPATHETIC BLOCKADE BY MONOAMINE OXIDASE INHIBITORS.

3. Isoprotenerol induction of pineal serotonin N-acetyltransferase in normotensive and spontaneously hypertensive rats.

4. Proceedings: The effect of melatonin on pinealectomy-induced hypertension in the rat.

5. Noradrenaline: central inhibitory control of blood pressure and heart rate.

6. Effects of rats of pinealectomy and oxypertine on spontaneous locomotor activity and blood pressure during various light schedules.

7. The effects of psychotropic drugs on the cardiovascular system.

8. An evaluation of phospholipids as regulators of monoamine oxidase A and monoamine oxidase B activities.

9. Excitatory effects of the vasodilator hydralazine on acoustic startle in the rat.

10. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats.

1. Chemical sympathectomy and clorgyline-induced stimulation of rat pineal melatonin synthesis.

Review 2. Methylene blue and its analogues as antidepressant compounds.