Literature DB >> 4915470

Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase.

D C Klein, J L Weller.   

Abstract

The activity of N-acetyltransferase in the rat pineal gland is more than 15 times higher at night than during the day. This circadian rhythm persists in complete darkness, or in blinded animals, and is suppressed in constant lighting. The N-acetyltransferase rhythm is 180 degrees out of phase with the serotonin rhythm and is similar to the norepinephrine and melatonin rhythms. Experiments in vitro indicate that norepinephrine, not serotonin, regulates the activity of N-acetyl-transferase through a highly specific receptor.

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Year:  1970        PMID： 4915470     DOI： 10.1126/science.169.3950.1093

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  113 in total

Review 1.  Circadian rhythms of indoleamines and serotonin N-acetyltransferase activity in the pineal gland.

Authors:  T Deguchi
Journal:  Mol Cell Biochem       Date:  1979-09-28       Impact factor: 3.396

2.  Heat-stable low molecular weight form of phosphodiesterases from bovine pineal gland.

Authors:  K Sankaran; I Hanbauer; W Lovenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

3.  Isoprotenerol induction of pineal serotonin N-acetyltransferase in normotensive and spontaneously hypertensive rats.

Authors:  H Illnerová; I Ablrecht
Journal:  Experientia       Date:  1975-01-15

4.  Daily change in pineal N-acetyltransferase activity in a diurnal mammal, the ground squirrel.

Authors:  J L Stephens; S Binkley
Journal:  Experientia       Date:  1978-11-15

5.  Control of circadian change of serotonin N-acetyltransferase activity in the pineal organ by the beta--adrenergic receptor.

Authors:  T Deguchi; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

6.  Control of the rat pineal gland by light spectra.

Authors:  D P Cardinali; F Larin; R J Wurtman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

7.  The rat suprachiasmatic nucleus is a clock for all seasons.

Authors:  A Sumová; Z Trávnícková; R Peters; W J Schwartz; H Illnerová
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

8.  Tentative immunohistochemical demonstration of melatonin in the rat pineal gland.

Authors:  D Freund; J Arendt; L Vollrath
Journal:  Cell Tissue Res       Date:  1977-07-11       Impact factor: 5.249

9.  Melatonin and gonadotropin secretion after acute exercise in physically active males.

Authors:  A N Elias; A F Wilson; M R Pandian; F J Rojas; R Kayaleh; S C Stone; N James
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1993

10.  The effects of a number of short-term exogenous stimuli on pineal serotonin-N-acetyltransferase activity in rats.

Authors:  H A Welker; L Vollrath
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575
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