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Literature DB >> 2574000

Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28.

M V Bell¹, J Bloomfield, M McKinley, M N Patterson, M G Darlison, E A Barnard, K E Davies.

Abstract

We report the physical linkage of the gene encoding one of the subunits of the GABAA receptor (GABRA3) to the polymorphic locus DXS374 on the human X chromosome at Xq28. X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders. DXS374--and therefore GABRA3--lies distal to the fragile X locus at a recombination fraction of approximately .15.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2574000 PMCID： PMC1683479

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

18 in total

1. Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.

Authors: P R Schofield; M G Darlison; N Fujita; D R Burt; F A Stephenson; H Rodriguez; L M Rhee; J Ramachandran; V Reale; T A Glencorse
Journal: Nature Date: 1987 Jul 16-22 Impact factor: 49.962

2. Separation of large DNA molecules by contour-clamped homogeneous electric fields.

Authors: G Chu; D Vollrath; R W Davis
Journal: Science Date: 1986-12-19 Impact factor: 47.728

Review 3. A review of the biochemical and neuropharmacological actions of lithium.

Authors: A J Wood; G M Goodwin
Journal: Psychol Med Date: 1987-08 Impact factor: 7.723

4. Characterization of the human factor VIII gene.

Authors: J Gitschier; W I Wood; T M Goralka; K L Wion; E Y Chen; D H Eaton; G A Vehar; D J Capon; R M Lawn
Journal: Nature Date: 1984 Nov 22-28 Impact factor: 49.962

5. Molecular analysis of the Duchenne muscular dystrophy region using pulsed field gel electrophoresis.

Authors: S Kenwrick; M Patterson; A Speer; K Fischbeck; K Davies
Journal: Cell Date: 1987-01-30 Impact factor: 41.582

6. Polymorphic DNA marker on X chromosome and manic depression.

Authors: J Mendlewicz; P Simon; S Sevy; F Charon; H Brocas; S Legros; G Vassart
Journal: Lancet Date: 1987-05-30 Impact factor: 79.321

7. Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region.

Authors: M G Persico; G Viglietto; G Martini; D Toniolo; G Paonessa; C Moscatelli; R Dono; T Vulliamy; L Luzzatto; M D'Urso
Journal: Nucleic Acids Res Date: 1986-03-25 Impact factor: 16.971

8. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

Authors: J Nathans; D Thomas; D S Hogness
Journal: Science Date: 1986-04-11 Impact factor: 47.728

9. Genetic linkage between X-chromosome markers and bipolar affective illness.

Authors: M Baron; N Risch; R Hamburger; B Mandel; S Kushner; M Newman; D Drumer; R H Belmaker
Journal: Nature Date: 1987 Mar 19-25 Impact factor: 49.962

10. Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.

Authors: K G Lloyd; F Thuret; A Pilc
Journal: J Pharmacol Exp Ther Date: 1985-10 Impact factor: 4.030

6 in total

Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28.

1. Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.

2. Separation of large DNA molecules by contour-clamped homogeneous electric fields.

Review 3. A review of the biochemical and neuropharmacological actions of lithium.

4. Characterization of the human factor VIII gene.

5. Molecular analysis of the Duchenne muscular dystrophy region using pulsed field gel electrophoresis.

6. Polymorphic DNA marker on X chromosome and manic depression.

7. Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region.

8. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

9. Genetic linkage between X-chromosome markers and bipolar affective illness.

10. Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.

1. Brief report: the association between autism and fragile X syndrome: a case report.

Review 2. Clinical aspects of multiple endocrine neoplasia type 1.

Review 3. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.

4. Comparative mapping on the mouse X chromosome defines a myotubular myopathy equivalent region.

5. Physical map of human Xq27-qter: localizing the region of the fragile X mutation.

6. Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes.