Literature DB >> 3037384

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.

P R Schofield, M G Darlison, N Fujita, D R Burt, F A Stephenson, H Rodriguez, L M Rhee, J Ramachandran, V Reale, T A Glencorse.   

Abstract

Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.

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Year:  1987        PMID： 3037384     DOI： 10.1038/328221a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  250 in total

1.  The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.

Authors:  M J Gunthorpe; J A Peters; C H Gill; J J Lambert; S C Lummis
Journal:  J Physiol       Date:  2000-01-15       Impact factor: 5.182

2.  Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.

Authors:  Y Chang; D S Weiss
Journal:  Biophys J       Date:  1999-11       Impact factor: 4.033

3.  Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity.

Authors:  Angelo Keramidas; Andrew J Moorhouse; Kerrie D Pierce; Peter R Schofield; Peter H Barry
Journal:  J Gen Physiol       Date:  2002-05       Impact factor: 4.086

4.  Positive allosteric modulation by ultraviolet irradiation on GABA(A), but not GABA(C), receptors expressed in Xenopus oocytes.

Authors:  Y Chang; Y Xie; D S Weiss
Journal:  J Physiol       Date:  2001-10-15       Impact factor: 5.182

5.  GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons.

Authors:  S Vicini; C Ferguson; K Prybylowski; J Kralic; A L Morrow; G E Homanics
Journal:  J Neurosci       Date:  2001-05-01       Impact factor: 6.167

Review 6.  Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission.

Authors:  Josef T Kittler; Kristina McAinsh; Stephen J Moss
Journal:  Mol Neurobiol       Date:  2002 Oct-Dec       Impact factor: 5.590

Review 7.  Unorthodox view of the functioning of a GABAA synapse.

Authors:  Aroldo Cupello; Maria Vittoria Rapallino
Journal:  Cell Mol Neurobiol       Date:  2002-04       Impact factor: 5.046

8.  Introduction to thematic minireview series on celebrating the discovery of the cysteine loop ligand-gated ion channel superfamily.

Authors:  F Anne Stephenson
Journal:  J Biol Chem       Date:  2012-10-04       Impact factor: 5.157

9.  Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.

Authors:  S M Cartmell; D Mitchell
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

10.  Strychnine affects catecholamine secretion from bovine adrenal medulla chromaffin cells.

Authors:  D E Dar; O Zinder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-07       Impact factor: 3.000
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