Literature DB >> 6438525

Characterization of the human factor VIII gene.

J Gitschier, W I Wood, T M Goralka, K L Wion, E Y Chen, D H Eaton, G A Vehar, D J Capon, R M Lawn.   

Abstract

The complete 186,000 base-pair (bp) human factor VIII gene has been isolated and consists of 26 exons ranging in size from 69 to 3,106 bp and introns as large as 32.4 kilobases (kb). Nine kb of mRNA and protein-coding DNA has been sequenced and the mRNA termini have been mapped. The relationship between internal duplications in factor VIII and evolution of the gene is discussed.

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Year:  1984        PMID： 6438525     DOI： 10.1038/312326a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  190 in total

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8.  Size and position of intervening sequences are critical for the splicing efficiency of pre-mRNA in the yeast Saccharomyces cerevisiae.

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9.  Immunohistochemical localization of vascular endothelial cell factor VIII/von Willebrand factor antigen in human normal and disordered gastric tissues.

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