| Literature DB >> 2884369 |
J Mendlewicz, P Simon, S Sevy, F Charon, H Brocas, S Legros, G Vassart.
Abstract
Heredity is an important factor in vulnerability to manic depression. A genetic linkage has been demonstrated between manic depression and coagulation factor IX at Xq27 with a TaqI polymorphism at the F9 locus in DNA samples from peripheral leucocytes of manic depressive probands and relatives in 10 informative families. Statistical analysis of the pedigrees gave a maximum lod score of 3.10 at a recombination fraction of 0.11, demonstrating a linkage between a manic depressive locus and the F9 locus in the Xq27 region.Entities:
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Year: 1987 PMID: 2884369 DOI: 10.1016/s0140-6736(87)92685-7
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321