Literature DB >> 2573400

A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip.

J S Gillespie1, H Sheng.   

Abstract

1. The inhibitory effect of erythrocyte suspensions and haemoglobin solutions on the response of the bovine retractor penis muscle (BRP) and the rat anococcygeus to field stimulation of their non-adrenergic non-cholinergic (NANC) nerves has been compared. Haemoglobin 3 microM greatly reduced the relaxant response in both tissues whereas a haemoglobin-equivalent suspension of erythrocytes was without effect. 2. A similar comparison of erythrocytes and haemoglobin on the response of the rabbit aortic strip to EDRF liberated by acetylcholine (ACh) showed that both reduced EDRF-mediated relaxation, though haemoglobin was significantly more effective. 3. These results suggest that the NANC transmitter may not be as freely diffusible through the erythrocyte membrane as EDRF and may therefore not be nitric oxide.

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Year:  1989        PMID： 2573400      PMCID： PMC1854703          DOI： 10.1111/j.1476-5381.1989.tb12616.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

1.  On the ultrastructure of the rat anococcygeus muscle.

Authors:  J S Gillespie; R Lüllmann-Rauch
Journal:  Cell Tissue Res       Date:  1974       Impact factor: 5.249

2.  Block of some non-adrenergic inhibitory responses of smooth muscle by a substance from haemolysed erythrocytes.

Authors:  A Bowman; J S Gillespie
Journal:  J Physiol       Date:  1982-07       Impact factor: 5.182

3.  Oxyhaemoglobin blocks non-adrenergic non-cholinergic inhibition in the bovine retractor penis muscle.

Authors:  A Bowman; J S Gillespie; D Pollock
Journal:  Eur J Pharmacol       Date:  1982-11-19       Impact factor: 4.432

4.  Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and non-vascular smooth muscle.

Authors:  J S Gillespie; H Sheng
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

5.  The nature of endothelium-derived vascular relaxant factor.

Authors:  T M Griffith; D H Edwards; M J Lewis; A C Newby; A H Henderson
Journal:  Nature       Date:  1984 Apr 12-18       Impact factor: 49.962

6.  Cyclic GMP mediates neurogenic relaxation in the bovine retractor penis muscle.

Authors:  A Bowman; A H Drummond
Journal:  Br J Pharmacol       Date:  1984-04       Impact factor: 8.739

7.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

8.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.

Authors:  R M Palmer; A G Ferrige; S Moncada
Journal:  Nature       Date:  1987 Jun 11-17       Impact factor: 49.962

9.  Possible role for cyclic GMP in endothelium-dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin.

Authors:  J Diamond; E B Chu
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1983-09

10.  The rat anococcygeus muscle and its response to nerve stimulation and to some drugs.

Authors:  J S Gillespie
Journal:  Br J Pharmacol       Date:  1972-07       Impact factor: 8.739
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  9 in total

1.  Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves from bovine retractor penis muscles.

Authors:  H Sheng; H H Schmidt; M Nakane; J A Mitchell; J S Pollock; U Föstermann; F Murad
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

2.  Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter.

Authors:  M La; C G Li; M J Rand
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

3.  Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions.

Authors:  A J Hobbs; J F Tucker; A Gibson
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739

Review 4.  Nitric oxide and lung disease.

Authors:  P J Barnes; M G Belvisi
Journal:  Thorax       Date:  1993-10       Impact factor: 9.139

5.  The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles.

Authors:  J S Gillespie; H Sheng
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

6.  Intravascular flow decreases erythrocyte consumption of nitric oxide.

Authors:  J C Liao; T W Hein; M W Vaughn; K T Huang; L Kuo
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

7.  Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.

Authors:  M J Rand; C G Li
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

8.  An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus.

Authors:  A Gibson; R Babbedge; S R Brave; S L Hart; A J Hobbs; J F Tucker; P Wallace; P K Moore
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

9.  Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle.

Authors:  M A Rajanayagam; C G Li; M J Rand
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739
  9 in total

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