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Literature DB >> 1691942

The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles.

Abstract

1. The effects of pyrogallol and hydroquinone on the bovine retractor penis (BRP) and rat anococcygeus muscles to non-adrenergic, non-cholinergic (NANC) nerve stimulation have been examined. Both drugs at a concentration of 10(-4) M significantly reduced the response in the rat anococcygeus muscle but had no effect in the BRP muscle. 2. The inhibition of the NANC response in the rat anococcygeus muscle by pyrogallol was completely reversed by superoxide dismutase suggesting it was due to the generation of superoxide anions. 3. Pyrogallol inhibited the response to nitric oxide (NO) in the rat anococcygeus muscle but not that to 3-isobutyl-1-methyl-xanthine (IBMX) which confirmed a selective action. 4. These results suggest that the NANC neurotransmitter in the rat anococcygeus muscle is susceptible to superoxide anions and may be NO or a substance that can liberate NO.

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Year: 1990 PMID： 1691942 PMCID： PMC1917525 DOI： 10.1111/j.1476-5381.1990.tb14677.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

17 in total

1. Block of some non-adrenergic inhibitory responses of smooth muscle by a substance from haemolysed erythrocytes.

Authors: A Bowman; J S Gillespie
Journal: J Physiol Date: 1982-07 Impact factor: 5.182

2. The effects of L-arginine and NG-monomethyl L-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation.

Authors: J S Gillespie; X R Liu; W Martin
Journal: Br J Pharmacol Date: 1989-12 Impact factor: 8.739

3. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

Authors: W Martin; G M Villani; D Jothianandan; R F Furchgott
Journal: J Pharmacol Exp Ther Date: 1985-03 Impact factor: 4.030

4. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor.

Authors: R J Gryglewski; R M Palmer; S Moncada
Journal: Nature Date: 1986 Apr 3-9 Impact factor: 49.962

5. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor.

Authors: G M Rubanyi; P M Vanhoutte
Journal: Am J Physiol Date: 1986-05

6. Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and non-vascular smooth muscle.

Authors: J S Gillespie; H Sheng
Journal: Br J Pharmacol Date: 1988-12 Impact factor: 8.739

7. Vascular endothelial cells synthesize nitric oxide from L-arginine.

Authors: R M Palmer; D S Ashton; S Moncada
Journal: Nature Date: 1988-06-16 Impact factor: 49.962

8. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.

Authors: R M Palmer; A G Ferrige; S Moncada
Journal: Nature Date: 1987 Jun 11-17 Impact factor: 49.962

9. The effect of hypoxia on neuroeffector transmission in the bovine retractor penis and rat anococcygeus muscles.

Authors: A Bowman; J C McGrath
Journal: Br J Pharmacol Date: 1985-08 Impact factor: 8.739

10. The rat anococcygeus muscle and its response to nerve stimulation and to some drugs.

Authors: J S Gillespie
Journal: Br J Pharmacol Date: 1972-07 Impact factor: 8.739

29 in total

Review 1. NO as a signalling molecule in the nervous system.

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2. Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves from bovine retractor penis muscles.

Authors: H Sheng; H H Schmidt; M Nakane; J A Mitchell; J S Pollock; U Föstermann; F Murad
Journal: Br J Pharmacol Date: 1992-08 Impact factor: 8.739

3. Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle.

Authors: J A Mitchell; H Sheng; U Förstermann; F Murad
Journal: Br J Pharmacol Date: 1991-10 Impact factor: 8.739

4. Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter.

Authors: M La; C G Li; M J Rand
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5. Patterns of co-existence of peptides and differences of nerve fibre types associated with noradrenergic and non-noradrenergic (putative cholinergic) neurons in the major pelvic ganglion of the male rat.

Authors: J R Keast
Journal: Cell Tissue Res Date: 1991-11 Impact factor: 5.249

6. Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions.

Authors: A J Hobbs; J F Tucker; A Gibson
Journal: Br J Pharmacol Date: 1991-11 Impact factor: 8.739

7. Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.

Authors: A J Barbier; R A Lefebvre
Journal: Br J Pharmacol Date: 1994-04 Impact factor: 8.739

8. Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols.

Authors: X Liu; J S Gillespie; W Martin
Journal: Br J Pharmacol Date: 1994-04 Impact factor: 8.739

9. Effects of NG-substituted analogues of L-arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscles and the bovine penile artery.

Authors: X R Liu; J S Gillespie; I F Gibson; W Martin
Journal: Br J Pharmacol Date: 1991-09 Impact factor: 8.739

10. Effect of neuropeptide Y on adrenergic and non-adrenergic, non-cholinergic responses in the rat anococcygeus muscle.

Authors: E Vila; A Tabernero; F Fernandes; M Salaices
Journal: Br J Pharmacol Date: 1992-09 Impact factor: 8.739