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Literature DB >> 8428210

Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle.

Abstract

In rat aortic rings, hydroxocobalamin (10-30 microM) produced concentration-dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium-dependent, NO-mediated, relaxant action of acetylcholine. In anococcygeus muscles, hydroxocobalamin (10-30 microM) reduced but also prolonged, NO-induced relaxations, but had no effect on non-adrenergic, non-cholinergic-mediated relaxations. Hydroxocobalamin had no effect on the NO-independent relaxant action of papaverine in either tissue. It is suggested that hydroxocobalamin sequesters NO by forming nitrosocobalamin. Nitrosocobalamin did not relax aortic rings, but produced a slowly developing and prolonged relaxation of anococcygeus muscles.

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Year: 1993 PMID： 8428210 PMCID： PMC1907706 DOI： 10.1111/j.1476-5381.1993.tb13429.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

8 in total

Review 1. Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

Authors: F Murad; C K Mittal; W P Arnold; S Katsuki; H Kimura
Journal: Adv Cyclic Nucleotide Res Date: 1978

2. A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip.

Authors: J S Gillespie; H Sheng
Journal: Br J Pharmacol Date: 1989-10 Impact factor: 8.739

3. Preparation of derivatives of ferrous and ferric hemoglobin.

Authors: E E Di Iorio
Journal: Methods Enzymol Date: 1981 Impact factor: 1.600

4. Vasodilation induced by acetylcholine and by glyceryl trinitrate in rat aortic and mesenteric vasculature.

Authors: M T Khan; D Jothianandan; K Matsunaga; R F Furchgott
Journal: J Vasc Res Date: 1992 Jan-Feb Impact factor: 1.934

5. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

Authors: W Martin; G M Villani; D Jothianandan; R F Furchgott
Journal: J Pharmacol Exp Ther Date: 1985-03 Impact factor: 4.030

6. Evidence for a role of nitric oxide in the neurotransmitter system mediating relaxation of the rat anococcygeus muscle.

Authors: C G Li; M J Rand
Journal: Clin Exp Pharmacol Physiol Date: 1989-12 Impact factor: 2.557

Review 7. Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission.

Authors: M J Rand
Journal: Clin Exp Pharmacol Physiol Date: 1992-03 Impact factor: 2.557

8. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

Authors: L J Ignarro; R E Byrns; G M Buga; K S Wood
Journal: Circ Res Date: 1987-12 Impact factor: 17.367

8 in total

26 in total

5. Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter.

Authors: M La; C G Li; M J Rand
Journal: Br J Pharmacol Date: 1996-03 Impact factor: 8.739

6. Effects of ethanol and other aliphatic alcohols on NO-mediated relaxations in rat anococcygeus muscles and gastric fundus strips.

Authors: M J Rand; C G Li
Journal: Br J Pharmacol Date: 1994-04 Impact factor: 8.739

10. Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.

Authors: M J Rand; C G Li
Journal: Br J Pharmacol Date: 1995-09 Impact factor: 8.739

Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle.

Review 1. Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

2. A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip.

3. Preparation of derivatives of ferrous and ferric hemoglobin.

4. Vasodilation induced by acetylcholine and by glyceryl trinitrate in rat aortic and mesenteric vasculature.

5. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

6. Evidence for a role of nitric oxide in the neurotransmitter system mediating relaxation of the rat anococcygeus muscle.

Review 7. Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission.

8. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1. Comparison of the redox forms of nitrogen monoxide with the nitrergic transmitter in the rat anococcygeus muscle.

Review 2. NO as a signalling molecule in the nervous system.

Review 3. NO and the vasculature: where does it come from and what does it do?

4. A novel role for HNO in local and spreading vasodilatation in rat mesenteric resistance arteries.

5. Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter.

6. Effects of ethanol and other aliphatic alcohols on NO-mediated relaxations in rat anococcygeus muscles and gastric fundus strips.

7. Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.

8. Multiple pathways underlying endothelium-dependent relaxation in the rabbit isolated femoral artery.

9. Nitric oxide synthase activity and non-adrenergic non-cholinergic relaxation in the rat gastric fundus.

10. Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.