Literature DB >> 1975560

Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy.

K V Walsh1, H G Harley, J D Brook, S A Rundle, M Sarfarazi, P S Harper, D J Shaw.   

Abstract

We have studied the genetic linkage of two markers, the apolipoprotein C1 (APOC1) gene and a cytochrome P450 (CYP2A) gene, in relation to the gene for myotonic dystrophy (DM). A peak lod score of 9.29 at 2 cM was observed for APOC1-DM, with a lod score of 8.55 at 4 cM for CYP2A-DM. These two markers also show close linkage to each other (theta max = 0.05, Zmax = 9.09). From examination of the genotypes of the recombinant individuals, CYP2A appears to map proximal to DM because in one recombinant individual CYP2A, APOC2 and CKMM had all recombined with DM. Evidence from another CYP2A-DM recombinant individual places CYP2A proximal to APOC2 and CKMM. Localisation of CYP2A on a panel of somatic cell hybrids also suggests that it is proximal to DM and APOC2/C1/E gene cluster.

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Year:  1990        PMID： 1975560     DOI： 10.1007/bf00206751

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  44 in total

1.  Localization of a human Na+,K+-ATPase alpha subunit gene to chromosome 19q12----q13.2 and linkage to the myotonic dystrophy locus.

Authors:  H G Harley; J D Brook; C L Jackson; T Glaser; K V Walsh; M Sarfarazi; R Kent; M Lager; M Koch; P S Harper
Journal:  Genomics       Date:  1988-11       Impact factor: 5.736

2.  Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites.

Authors:  D J Shaw; H G Harley; J D Brook; T W McKeithan
Journal:  Hum Genet       Date:  1989-08       Impact factor: 4.132

3.  Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

Authors:  J S Miles; W Bickmore; J D Brook; A W McLaren; R Meehan; C R Wolf
Journal:  Nucleic Acids Res       Date:  1989-04-25       Impact factor: 16.971

4.  Criteria for establishing the validity of genetic recombination in myotonic dystrophy.

Authors:  R C Griggs; D S Wood
Journal:  Neurology       Date:  1989-03       Impact factor: 9.910

5.  Genetic linkage between the loci for myotonic dystrophy and peptidase D.

Authors:  T O'Brien; S Ball; M Sarfarazi; P S Harper; E B Robson
Journal:  Ann Hum Genet       Date:  1983-05       Impact factor: 1.670

6.  A chromosome 19 clone from a translocation breakpoint shows close linkage and linkage disequilibrium with myotonic dystrophy.

Authors:  R G Korneluk; H L MacLeod; T W McKeithan; J D Brooks; A E MacKenzie
Journal:  Genomics       Date:  1989-02       Impact factor: 5.736

7.  The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man.

Authors:  O Myklebost; S Rogne; B Olaisen; T Gedde-Dahl; H Prydz
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

8.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

9.  Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

Authors:  D L Simmons; C B Kasper
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157

10.  Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

Authors:  D L Simmons; P A Lalley; C B Kasper
Journal:  J Biol Chem       Date:  1985-01-10       Impact factor: 5.157
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  5 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

Authors:  H G Harley; K V Walsh; S Rundle; J D Brook; M Sarfarazi; M C Koch; J L Floyd; P S Harper; D J Shaw
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

Review 3.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

4.  Identification of new DNA markers close to the myotonic dystrophy locus.

Authors:  J D Brook; H G Harley; K V Walsh; S A Rundle; M J Siciliano; P S Harper; D J Shaw
Journal:  J Med Genet       Date:  1991-02       Impact factor: 6.318

5.  Detection of linkage disequilibrium between the myotonic dystrophy locus and a new polymorphic DNA marker.

Authors:  H G Harley; J D Brook; J Floyd; S A Rundle; S Crow; K V Walsh; M C Thibault; P S Harper; D J Shaw
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025
  5 in total

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