Literature DB >> 25673794

A signal-to-cutoff ratio in the Abbott architect HIV Ag/Ab Combo assay that predicts subsequent confirmation of HIV-1 infection in a low-prevalence setting.

Tomas Ostergaard Jensen1, Peter Robertson2, Ross Whybin2, Ian Chambers3, Monica Lahra2, William Rawlinson2, Jeffrey John Post4.   

Abstract

A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25673794      PMCID： PMC4400779          DOI： 10.1128/JCM.03583-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  16 in total

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2.  False-positive rate of a "fourth-generation" HIV antigen/antibody combination assay in an area of low HIV prevalence.

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3.  Evaluation of the performance of the Abbott ARCHITECT HIV Ag/Ab Combo Assay.

Authors:  Pollyanna Chavez; Laura Wesolowski; Pragna Patel; Kevin Delaney; S Michele Owen
Journal:  J Clin Virol       Date:  2011-10-07       Impact factor: 3.168

4.  Use of laboratory tests and clinical symptoms for identification of primary HIV infection.

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  11 in total

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6.  Sample-to-cutoff ratios using Architect HIV Ag/Ab Combo: The influence with the results of supplemental tests and optimal cutoff value to predict HIV infection.

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10.  Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population.

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