Jason L Vassy1, Kurt D Christensen2, Melody J Slashinski3, Denise M Lautenbach2, Sridharan Raghavan4, Jill Oliver Robinson5, Jennifer Blumenthal-Barby5, Lindsay Zausmer Feuerman5, Lisa Soleymani Lehmann6, Michael F Murray7, Robert C Green2, Amy L McGuire5. 1. Section of General Internal Medicine, VA Boston Healthcare System, Boston, MA 02130, USA ; Division of General Medicine & Primary Care, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. 2. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; Division of Genetics, Brigham & Women's Hospital, Boston, MA 02115, USA. 3. School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA. 4. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA. 5. Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. 6. Division of General Medicine & Primary Care, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA. 7. Geisinger Health System, Danville, PA 17822 4910, USA.
Abstract
AIM: To describe practicing physicians' perceived clinical utility of genome sequencing. MATERIALS & METHODS: We conducted a mixed-methods analysis of data from 18 primary care physicians and cardiologists in a study of the clinical integration of whole-genome sequencing. Physicians underwent brief genomics continuing medical education before completing surveys and semi-structured interviews. RESULTS: Physicians described sequencing as currently lacking clinical utility because of its uncertain interpretation and limited impact on clinical decision-making, but they expressed the idea that its clinical integration was inevitable. Potential clinical uses for sequencing included complementing other clinical information, risk stratification, motivating patient behavior change and pharmacogenetics. CONCLUSION: Physicians given genomics continuing medical education use the language of both evidence-based and personalized medicine in describing the utility of genome-wide testing in patient care.
AIM: To describe practicing physicians' perceived clinical utility of genome sequencing. MATERIALS & METHODS: We conducted a mixed-methods analysis of data from 18 primary care physicians and cardiologists in a study of the clinical integration of whole-genome sequencing. Physicians underwent brief genomics continuing medical education before completing surveys and semi-structured interviews. RESULTS: Physicians described sequencing as currently lacking clinical utility because of its uncertain interpretation and limited impact on clinical decision-making, but they expressed the idea that its clinical integration was inevitable. Potential clinical uses for sequencing included complementing other clinical information, risk stratification, motivating patient behavior change and pharmacogenetics. CONCLUSION: Physicians given genomics continuing medical education use the language of both evidence-based and personalized medicine in describing the utility of genome-wide testing in patient care.
Entities:
Keywords:
genomics; high-throughput nucleotide sequencing; pharmacogenetics; physician’s practice patterns; qualitative research
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