Literature DB >> 25622574

Selenocysteine incorporation: A trump card in the game of mRNA decay.

Sumangala P Shetty1, Paul R Copeland2.   

Abstract

The incorporation of the 21st amino acid, selenocysteine (Sec), occurs on mRNAs that harbor in-frame stop codons because the Sec-tRNA(Sec) recognizes a UGA codon. This sets up an intriguing interplay between translation elongation, translation termination and the complex machinery that marks mRNAs that contain premature termination codons for degradation, leading to nonsense mediated mRNA decay (NMD). In this review we discuss the intricate and complex relationship between this key quality control mechanism and the process of Sec incorporation in mammals.
Copyright © 2015 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved.

Entities:  

Keywords:  NMD; Selenocysteine; mRNA decay

Mesh：

Substances：

Year:  2015        PMID： 25622574      PMCID： PMC4458392          DOI： 10.1016/j.biochi.2015.01.007

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  44 in total

Review 1.  No-go decay: a quality control mechanism for RNA in translation.

Authors:  Yuriko Harigaya; Roy Parker
Journal:  Wiley Interdiscip Rev RNA       Date:  2010-05-06       Impact factor: 9.957

2.  Translational redefinition of UGA codons is regulated by selenium availability.

Authors:  Michael T Howard; Bradley A Carlson; Christine B Anderson; Dolph L Hatfield
Journal:  J Biol Chem       Date:  2013-05-21       Impact factor: 5.157

3.  Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice.

Authors:  Sandra Seeher; Bradley A Carlson; Angela C Miniard; Eva K Wirth; Yassin Mahdi; Dolph L Hatfield; Donna M Driscoll; Ulrich Schweizer
Journal:  Biochem J       Date:  2014-08-15       Impact factor: 3.857

4.  Polysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: evidence for a block in elongation at the UGA/selenocysteine codon.

Authors:  J E Fletcher; P R Copeland; D M Driscoll
Journal:  RNA       Date:  2000-11       Impact factor: 4.942

5.  Selenocysteine codons decrease polysome association on endogenous selenoprotein mRNAs.

Authors:  G W Martin ; M J Berry
Journal:  Genes Cells       Date:  2001-02       Impact factor: 1.891

6.  Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position.

Authors:  X Sun; P M Moriarty; L E Maquat
Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

7.  Identification of a signature motif for the eIF4a3-SECIS interaction.

Authors:  Michael E Budiman; Jodi L Bubenik; Donna M Driscoll
Journal:  Nucleic Acids Res       Date:  2011-06-17       Impact factor: 16.971

8.  Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.

Authors:  Jesse Donovan; Paul R Copeland
Journal:  PLoS One       Date:  2012-04-17       Impact factor: 3.240

9.  Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency.

Authors:  Ali Seyedali; Marla J Berry
Journal:  RNA       Date:  2014-06-19       Impact factor: 4.942

10.  Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.

Authors:  Jodi L Bubenik; Angela C Miniard; Donna M Driscoll
Journal:  PLoS One       Date:  2013-04-16       Impact factor: 3.240
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  16 in total

Review 1.  Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.

Authors:  Søren Lykke-Andersen; Torben Heick Jensen
Journal:  Nat Rev Mol Cell Biol       Date:  2015-09-23       Impact factor: 94.444

Review 2.  Molecular mechanism of selenoprotein P synthesis.

Authors:  Sumangala Shetty; Paul R Copeland
Journal:  Biochim Biophys Acta Gen Subj       Date:  2018-04-12       Impact factor: 3.770

Review 3.  On elongation factor eEFSec, its role and mechanism during selenium incorporation into nascent selenoproteins.

Authors:  Miljan Simonović; Anupama K Puppala
Journal:  Biochim Biophys Acta Gen Subj       Date:  2018-03-17       Impact factor: 3.770

4.  Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis.

Authors:  Erik Schoenmakers; Bradley Carlson; Maura Agostini; Carla Moran; Odelia Rajanayagam; Elena Bochukova; Ryuta Tobe; Rachel Peat; Evelien Gevers; Francesco Muntoni; Pascale Guicheney; Nadia Schoenmakers; Sadaf Farooqi; Greta Lyons; Dolph Hatfield; Krishna Chatterjee
Journal:  J Clin Invest       Date:  2016-02-08       Impact factor: 14.808

5.  Enhanced antioxidant capacity prevents epitranscriptomic and cardiac alterations in adult offspring gestationally-exposed to ENM.

Authors:  Amina Kunovac; Quincy A Hathaway; Mark V Pinti; Andrya J Durr; Andrew D Taylor; William T Goldsmith; Krista L Garner; Timothy R Nurkiewicz; John M Hollander
Journal:  Nanotoxicology       Date:  2021-05-08       Impact factor: 5.913

6.  Inherited Selenocysteine Transfer RNA Mutation: Clinical and Hormonal Evaluation of 2 Patients.

Authors:  Aurore Geslot; Frédérique Savagner; Philippe Caron
Journal:  Eur Thyroid J       Date:  2021-08-26

7.  Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.

Authors:  Malgorzata Dobosz-Bartoszek; Mark H Pinkerton; Zbyszek Otwinowski; Srinivas Chakravarthy; Dieter Söll; Paul R Copeland; Miljan Simonović
Journal:  Nat Commun       Date:  2016-10-06       Impact factor: 14.919

8.  Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.

Authors:  Sen Wu; Marco Mariotti; Didac Santesmasses; Kristina E Hill; Janinah Baclaocos; Estel Aparicio-Prat; Shuping Li; John Mackrill; Yuanyuan Wu; Michael T Howard; Mario Capecchi; Roderic Guigó; Raymond F Burk; John F Atkins
Journal:  Open Biol       Date:  2016-11       Impact factor: 6.411

Review 9.  Control of gene expression through the nonsense-mediated RNA decay pathway.

Authors:  Andrew Nickless; Julie M Bailis; Zhongsheng You
Journal:  Cell Biosci       Date:  2017-05-19       Impact factor: 7.133

10.  The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay.

Authors:  Noelia Fradejas-Villar; Sandra Seeher; Christine B Anderson; Michael Doengi; Bradley A Carlson; Dolph L Hatfield; Ulrich Schweizer; Michael T Howard
Journal:  Nucleic Acids Res       Date:  2017-04-20       Impact factor: 16.971
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