Literature DB >> 26397022

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.

Søren Lykke-Andersen1, Torben Heick Jensen1.   

Abstract

Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.

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Year:  2015        PMID： 26397022     DOI： 10.1038/nrm4063

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  141 in total

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2.  An alternative branch of the nonsense-mediated decay pathway.

Authors:  Wai-Kin Chan; Lulu Huang; Jayanthi P Gudikote; Yao-Fu Chang; J Saadi Imam; James A MacLean; Miles F Wilkinson
Journal:  EMBO J       Date:  2007-03-15       Impact factor: 11.598

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Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

4.  Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response.

Authors:  Lawrence B Gardner
Journal:  Mol Cell Biol       Date:  2008-03-24       Impact factor: 4.272

5.  Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome.

Authors:  Kazushige Kuroha; Tsuyako Tatematsu; Toshifumi Inada
Journal:  EMBO Rep       Date:  2009-10-02       Impact factor: 8.807

6.  Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon.

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Journal:  RNA       Date:  2011-03-09       Impact factor: 4.942

7.  Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.

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Journal:  Structure       Date:  2012-10-18       Impact factor: 5.006

8.  Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.

Authors:  A Yamashita; T Ohnishi; I Kashima; Y Taya; S Ohno
Journal:  Genes Dev       Date:  2001-09-01       Impact factor: 11.361

Review 9.  Nonsense-mediated decay in genetic disease: friend or foe?

Authors:  Jake N Miller; David A Pearce
Journal:  Mutat Res Rev Mutat Res       Date:  2014-05-28       Impact factor: 5.657

10.  Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells.

Authors:  Sébastien Durand; Jens Lykke-Andersen
Journal:  Nat Struct Mol Biol       Date:  2013-05-12       Impact factor: 15.369
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  293 in total

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Review 3.  The DDX5/Dbp2 subfamily of DEAD-box RNA helicases.

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Review 5.  Human gene essentiality.

Authors:  István Bartha; Julia di Iulio; J Craig Venter; Amalio Telenti
Journal:  Nat Rev Genet       Date:  2017-10-30       Impact factor: 53.242

6.  The phenotypic landscape of a Tbc1d24 mutant mouse includes convulsive seizures resembling human early infantile epileptic encephalopathy.

Authors:  Risa Tona; Wenqian Chen; Yoko Nakano; Laura D Reyes; Ronald S Petralia; Ya-Xian Wang; Matthew F Starost; Talah T Wafa; Robert J Morell; Kevin D Cravedi; Johann du Hoffmann; Takushi Miyoshi; Jeeva P Munasinghe; Tracy S Fitzgerald; Yogita Chudasama; Koichi Omori; Carlo Pierpaoli; Botond Banfi; Lijin Dong; Inna A Belyantseva; Thomas B Friedman
Journal:  Hum Mol Genet       Date:  2019-05-01       Impact factor: 6.150

7.  RNA2DNAlign: nucleotide resolution allele asymmetries through quantitative assessment of RNA and DNA paired sequencing data.

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8.  The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.

Authors:  Sharon Soucek; Yi Zeng; Deepti L Bellur; Megan Bergkessel; Kevin J Morris; Qiudong Deng; Duc Duong; Nicholas T Seyfried; Christine Guthrie; Jonathan P Staley; Milo B Fasken; Anita H Corbett
Journal:  Mol Cell Biol       Date:  2016-08-15       Impact factor: 4.272

Review 9.  Role of the C9ORF72 Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Authors:  Zongbing Hao; Rui Wang; Haigang Ren; Guanghui Wang
Journal:  Neurosci Bull       Date:  2020-08-29       Impact factor: 5.203

10.  Characterization of CRISPR Mutants Targeting Genes Modulating Pectin Degradation in Ripening Tomato.

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Journal:  Plant Physiol       Date:  2018-11-20       Impact factor: 8.340
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