Sumangala Shetty1, Paul R Copeland2. 1. Department of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States. 2. Department of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States. Electronic address: paul.copeland@rutgers.edu.
Abstract
BACKGROUND: Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalian selenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events. SCOPE OF REVIEW: In this review we elaborate on new data and current models that provide insight into how SELENOP is made. MAJOR CONCLUSIONS: SELENOP synthesis requires a specific set of factors and conditions. GENERAL SIGNIFICANCE: As the key protein required for proper selenium distribution, SELENOP stands out as a lynchpin selenoprotein that is essential for male fertility, proper neurologic function and selenium metabolism.
BACKGROUND:Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalianselenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events. SCOPE OF REVIEW: In this review we elaborate on new data and current models that provide insight into how SELENOP is made. MAJOR CONCLUSIONS:SELENOP synthesis requires a specific set of factors and conditions. GENERAL SIGNIFICANCE: As the key protein required for proper selenium distribution, SELENOP stands out as a lynchpin selenoprotein that is essential for male fertility, proper neurologic function and selenium metabolism.
Authors: Marco Mariotti; Sumangala Shetty; Lisa Baird; Sen Wu; Gary Loughran; Paul R Copeland; John F Atkins; Michael T Howard Journal: Nucleic Acids Res Date: 2017-12-15 Impact factor: 16.971
Authors: Suguru Kurokawa; Sofi Eriksson; Kristie L Rose; Sen Wu; Amy K Motley; Salisha Hill; Virginia P Winfrey; W Hayes McDonald; Mario R Capecchi; John F Atkins; Elias S J Arnér; Kristina E Hill; Raymond F Burk Journal: Free Radic Biol Med Date: 2014-01-14 Impact factor: 7.376