| Literature DB >> 25619688 |
Jason M Norman1, Scott A Handley1, Megan T Baldridge1, Lindsay Droit1, Catherine Y Liu1, Brian C Keller2, Amal Kambal1, Cynthia L Monaco2, Guoyan Zhao3, Phillip Fleshner4, Thaddeus S Stappenbeck1, Dermot P B McGovern5, Ali Keshavarzian6, Ece A Mutlu6, Jenny Sauk7, Dirk Gevers8, Ramnik J Xavier9, David Wang3, Miles Parkes10, Herbert W Virgin11.
Abstract
Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.Entities:
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Year: 2015 PMID： 25619688 PMCID： PMC4312520 DOI： 10.1016/j.cell.2015.01.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582