Literature DB >> 25618516

Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index.

Jin Li1, Jinxiu Shi2, Wei Huang2, Jielin Sun3, Ying Wu4, Qing Duan1, Jingchun Luo5, Leslie A Lange1, Penny Gordon-Larsen6, S Lilly Zheng7, Wentao Yuan2, Ying Wang2, Barry M Popkin6, Zengnan Mo8, Jianfeng Xu7, Shufa Du6, Karen L Mohlke1, Ethan M Lange9.   

Abstract

BACKGROUND: The objective of this study was to investigate the genetic association of 4 candidate variants with blood pressure and test the modifying effects of environmental factors including age, sex, and body mass index (BMI).
METHODS: We used a linear mixed-effects model to test for variant main effects and variant interactions with age, sex, and BMI on systolic (SBP) and diastolic (DBP) blood pressure in 7,319 Chinese adults from the China Health and Nutrition Survey (CHNS). We attempted to replicate our significant interaction findings in 1,996 Chinese men from the Fangchenggang Area Male Health and Examination Survey (FAMHES).
RESULTS: Two variants (rs11105378 near ATP2B1 and rs1458038 near FGF5) were significantly associated (P < 0.00625 = 0.05/8) with both SBP and DBP in CHNS. Variant rs1378942 near CSK was nominally associated with SBP (P = 0.01). The signal at rs1458038 exhibited a genotype-by-BMI interaction affecting blood pressure (P interaction = 0.0018 for SBP; P interaction = 0.049 for DBP), with the strongest variant effects in those with the highest BMI. In FAMHES, rs1458038 also showed stronger effects on SBP and DBP among men with the highest BMI.
CONCLUSIONS: Our findings suggest high BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5, further highlighting the importance of obesity prevention in reducing hypertension risk. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  BMI; FGF5; blood pressure; hypertension; interaction.

Mesh:

Substances:

Year:  2015        PMID: 25618516      PMCID: PMC4542636          DOI: 10.1093/ajh/hpu263

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN: 0895-7061            Impact factor:   2.689


  33 in total

Review 1.  Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension.

Authors:  Michiel P De Boer; Rick I Meijer; Nienke J Wijnstok; Amy M Jonk; Alphons J Houben; Coen D Stehouwer; Yvo M Smulders; Etto C Eringa; Erik H Serné
Journal:  Microcirculation       Date:  2012-01       Impact factor: 2.628

2.  Cohort Profile: The China Health and Nutrition Survey--monitoring and understanding socio-economic and health change in China, 1989-2011.

Authors:  Barry M Popkin; Shufa Du; Fengying Zhai; Bing Zhang
Journal:  Int J Epidemiol       Date:  2009-11-03       Impact factor: 7.196

3.  Impact of obesity on 24-hour ambulatory blood pressure and hypertension.

Authors:  Vasilios Kotsis; Stella Stabouli; Marshall Bouldin; Annette Low; Savvas Toumanidis; Nikos Zakopoulos
Journal:  Hypertension       Date:  2005-02-21       Impact factor: 10.190

4.  The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

Authors:  Alexei Kharitonenkov; Victor J Wroblewski; Anja Koester; Yun-Fei Chen; Cathleen K Clutinger; Xenia T Tigno; Barbara C Hansen; Armen B Shanafelt; Garret J Etgen
Journal:  Endocrinology       Date:  2006-10-26       Impact factor: 4.736

5.  Global burden of hypertension: analysis of worldwide data.

Authors:  Patricia M Kearney; Megan Whelton; Kristi Reynolds; Paul Muntner; Paul K Whelton; Jiang He
Journal:  Lancet       Date:  2005 Jan 15-21       Impact factor: 79.321

6.  Body mass index and the prevalence of hypertension and dyslipidemia.

Authors:  C D Brown; M Higgins; K A Donato; F C Rohde; R Garrison; E Obarzanek; N D Ernst; M Horan
Journal:  Obes Res       Date:  2000-12

7.  Hypertension-independent microvascular rarefaction in the obese Zucker rat model of the metabolic syndrome.

Authors:  Jefferson C Frisbee
Journal:  Microcirculation       Date:  2005 Jul-Aug       Impact factor: 2.628

8.  Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.

Authors:  Aram V Chobanian; George L Bakris; Henry R Black; William C Cushman; Lee A Green; Joseph L Izzo; Daniel W Jones; Barry J Materson; Suzanne Oparil; Jackson T Wright; Edward J Roccella
Journal:  Hypertension       Date:  2003-12-01       Impact factor: 10.190

9.  Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.

Authors:  Xiaobo Yang; Jielin Sun; Yong Gao; Aihua Tan; Haiying Zhang; Yanling Hu; Junjie Feng; Xue Qin; Sha Tao; Zhuo Chen; Seong-Tae Kim; Tao Peng; Ming Liao; Xiaoling Lin; Zengfeng Zhang; Minzhong Tang; Li Li; Linjian Mo; Zhengjia Liang; Deyi Shi; Zhang Huang; Xianghua Huang; Ming Liu; Qian Liu; Shijun Zhang; Jeffrey M Trent; S Lilly Zheng; Jianfeng Xu; Zengnan Mo
Journal:  PLoS Genet       Date:  2012-09-13       Impact factor: 5.917

10.  Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:  Georg B Ehret; Patricia B Munroe; Kenneth M Rice; Murielle Bochud; Andrew D Johnson; Daniel I Chasman; Albert V Smith; Martin D Tobin; Germaine C Verwoert; Shih-Jen Hwang; Vasyl Pihur; Peter Vollenweider; Paul F O'Reilly; Najaf Amin; Jennifer L Bragg-Gresham; Alexander Teumer; Nicole L Glazer; Lenore Launer; Jing Hua Zhao; Yurii Aulchenko; Simon Heath; Siim Sõber; Afshin Parsa; Jian'an Luan; Pankaj Arora; Abbas Dehghan; Feng Zhang; Gavin Lucas; Andrew A Hicks; Anne U Jackson; John F Peden; Toshiko Tanaka; Sarah H Wild; Igor Rudan; Wilmar Igl; Yuri Milaneschi; Alex N Parker; Cristiano Fava; John C Chambers; Ervin R Fox; Meena Kumari; Min Jin Go; Pim van der Harst; Wen Hong Linda Kao; Marketa Sjögren; D G Vinay; Myriam Alexander; Yasuharu Tabara; Sue Shaw-Hawkins; Peter H Whincup; Yongmei Liu; Gang Shi; Johanna Kuusisto; Bamidele Tayo; Mark Seielstad; Xueling Sim; Khanh-Dung Hoang Nguyen; Terho Lehtimäki; Giuseppe Matullo; Ying Wu; Tom R Gaunt; N Charlotte Onland-Moret; Matthew N Cooper; Carl G P Platou; Elin Org; Rebecca Hardy; Santosh Dahgam; Jutta Palmen; Veronique Vitart; Peter S Braund; Tatiana Kuznetsova; Cuno S P M Uiterwaal; Adebowale Adeyemo; Walter Palmas; Harry Campbell; Barbara Ludwig; Maciej Tomaszewski; Ioanna Tzoulaki; Nicholette D Palmer; Thor Aspelund; Melissa Garcia; Yen-Pei C Chang; Jeffrey R O'Connell; Nanette I Steinle; Diederick E Grobbee; Dan E Arking; Sharon L Kardia; Alanna C Morrison; Dena Hernandez; Samer Najjar; Wendy L McArdle; David Hadley; Morris J Brown; John M Connell; Aroon D Hingorani; Ian N M Day; Debbie A Lawlor; John P Beilby; Robert W Lawrence; Robert Clarke; Jemma C Hopewell; Halit Ongen; Albert W Dreisbach; Yali Li; J Hunter Young; Joshua C Bis; Mika Kähönen; Jorma Viikari; Linda S Adair; Nanette R Lee; Ming-Huei Chen; Matthias Olden; Cristian Pattaro; Judith A Hoffman Bolton; Anna Köttgen; Sven Bergmann; Vincent Mooser; Nish Chaturvedi; Timothy M Frayling; Muhammad Islam; Tazeen H Jafar; Jeanette Erdmann; Smita R Kulkarni; Stefan R Bornstein; Jürgen Grässler; Leif Groop; Benjamin F Voight; Johannes Kettunen; Philip Howard; Andrew Taylor; Simonetta Guarrera; Fulvio Ricceri; Valur Emilsson; Andrew Plump; Inês Barroso; Kay-Tee Khaw; Alan B Weder; Steven C Hunt; Yan V Sun; Richard N Bergman; Francis S Collins; Lori L Bonnycastle; Laura J Scott; Heather M Stringham; Leena Peltonen; Markus Perola; Erkki Vartiainen; Stefan-Martin Brand; Jan A Staessen; Thomas J Wang; Paul R Burton; Maria Soler Artigas; Yanbin Dong; Harold Snieder; Xiaoling Wang; Haidong Zhu; Kurt K Lohman; Megan E Rudock; Susan R Heckbert; Nicholas L Smith; Kerri L Wiggins; Ayo Doumatey; Daniel Shriner; Gudrun Veldre; Margus Viigimaa; Sanjay Kinra; Dorairaj Prabhakaran; Vikal Tripathy; Carl D Langefeld; Annika Rosengren; Dag S Thelle; Anna Maria Corsi; Andrew Singleton; Terrence Forrester; Gina Hilton; Colin A McKenzie; Tunde Salako; Naoharu Iwai; Yoshikuni Kita; Toshio Ogihara; Takayoshi Ohkubo; Tomonori Okamura; Hirotsugu Ueshima; Satoshi Umemura; Susana Eyheramendy; Thomas Meitinger; H-Erich Wichmann; Yoon Shin Cho; Hyung-Lae Kim; Jong-Young Lee; James Scott; Joban S Sehmi; Weihua Zhang; Bo Hedblad; Peter Nilsson; George Davey Smith; Andrew Wong; Narisu Narisu; Alena Stančáková; Leslie J Raffel; Jie Yao; Sekar Kathiresan; Christopher J O'Donnell; Stephen M Schwartz; M Arfan Ikram; W T Longstreth; Thomas H Mosley; Sudha Seshadri; Nick R G Shrine; Louise V Wain; Mario A Morken; Amy J Swift; Jaana Laitinen; Inga Prokopenko; Paavo Zitting; Jackie A Cooper; Steve E Humphries; John Danesh; Asif Rasheed; Anuj Goel; Anders Hamsten; Hugh Watkins; Stephan J L Bakker; Wiek H van Gilst; Charles S Janipalli; K Radha Mani; Chittaranjan S Yajnik; Albert Hofman; Francesco U S Mattace-Raso; Ben A Oostra; Ayse Demirkan; Aaron Isaacs; Fernando Rivadeneira; Edward G Lakatta; Marco Orru; Angelo Scuteri; Mika Ala-Korpela; Antti J Kangas; Leo-Pekka Lyytikäinen; Pasi Soininen; Taru Tukiainen; Peter Würtz; Rick Twee-Hee Ong; Marcus Dörr; Heyo K Kroemer; Uwe Völker; Henry Völzke; Pilar Galan; Serge Hercberg; Mark Lathrop; Diana Zelenika; Panos Deloukas; Massimo Mangino; Tim D Spector; Guangju Zhai; James F Meschia; Michael A Nalls; Pankaj Sharma; Janos Terzic; M V Kranthi Kumar; Matthew Denniff; Ewa Zukowska-Szczechowska; Lynne E Wagenknecht; F Gerald R Fowkes; Fadi J Charchar; Peter E H Schwarz; Caroline Hayward; Xiuqing Guo; Charles Rotimi; Michiel L Bots; Eva Brand; Nilesh J Samani; Ozren Polasek; Philippa J Talmud; Fredrik Nyberg; Diana Kuh; Maris Laan; Kristian Hveem; Lyle J Palmer; Yvonne T van der Schouw; Juan P Casas; Karen L Mohlke; Paolo Vineis; Olli Raitakari; Santhi K Ganesh; Tien Y Wong; E Shyong Tai; Richard S Cooper; Markku Laakso; Dabeeru C Rao; Tamara B Harris; Richard W Morris; Anna F Dominiczak; Mika Kivimaki; Michael G Marmot; Tetsuro Miki; Danish Saleheen; Giriraj R Chandak; Josef Coresh; Gerjan Navis; Veikko Salomaa; Bok-Ghee Han; Xiaofeng Zhu; Jaspal S Kooner; Olle Melander; Paul M Ridker; Stefania Bandinelli; Ulf B Gyllensten; Alan F Wright; James F Wilson; Luigi Ferrucci; Martin Farrall; Jaakko Tuomilehto; Peter P Pramstaller; Roberto Elosua; Nicole Soranzo; Eric J G Sijbrands; David Altshuler; Ruth J F Loos; Alan R Shuldiner; Christian Gieger; Pierre Meneton; Andre G Uitterlinden; Nicholas J Wareham; Vilmundur Gudnason; Jerome I Rotter; Rainer Rettig; Manuela Uda; David P Strachan; Jacqueline C M Witteman; Anna-Liisa Hartikainen; Jacques S Beckmann; Eric Boerwinkle; Ramachandran S Vasan; Michael Boehnke; Martin G Larson; Marjo-Riitta Järvelin; Bruce M Psaty; Gonçalo R Abecasis; Aravinda Chakravarti; Paul Elliott; Cornelia M van Duijn; Christopher Newton-Cheh; Daniel Levy; Mark J Caulfield; Toby Johnson
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

View more
  8 in total

1.  Association of genetic variation with blood pressure traits among East Africans.

Authors:  J Kayima; J Liang; Y Natanzon; J Nankabirwa; I Ssinabulya; J Nakibuuka; A Katamba; H Mayanja-Kizza; A Miron; C Li; X Zhu
Journal:  Clin Genet       Date:  2017-03-19       Impact factor: 4.438

Review 2.  Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.

Authors:  Worapaka Manosroi; Gordon H Williams
Journal:  Endocr Rev       Date:  2019-06-01       Impact factor: 19.871

3.  Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.

Authors:  Hiroyuki Nakashima; Masahiro Nakashima; Manabu Kinoshita; Masami Ikarashi; Hiromi Miyazaki; Hiromi Hanaka; Junko Imaki; Shuhji Seki
Journal:  Sci Rep       Date:  2016-10-06       Impact factor: 4.379

4.  Urban-rural disparities in hypertension prevalence, detection, and medication use among Chinese Adults from 1993 to 2011.

Authors:  Jiajia Li; Leiyu Shi; Shixue Li; Lingzhong Xu; Wen Qin; Heng Wang
Journal:  Int J Equity Health       Date:  2017-03-14

5.  Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults.

Authors:  Yeong Mi Park; Chang Keun Kwock; Kyunga Kim; Jihye Kim; Yoon Jung Yang
Journal:  Nutrients       Date:  2017-03-05       Impact factor: 5.717

6.  Using Genetic Risk Score Approaches to Infer Whether an Environmental Factor Attenuates or Exacerbates the Adverse Influence of a Candidate Gene.

Authors:  Wan-Yu Lin; Yu-Shun Lin; Chang-Chuan Chan; Yu-Li Liu; Shih-Jen Tsai; Po-Hsiu Kuo
Journal:  Front Genet       Date:  2020-05-08       Impact factor: 4.599

7.  FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.

Authors:  Yuhua Li; Shengyu Cui; Bing Wu; Jixian Gao; Ming Li; Furong Zhang; Hao Xia
Journal:  Biochem Biophys Res Commun       Date:  2022-10-03       Impact factor: 3.322

8.  The rs1458038 variant near FGF5 is associated with poor response to calcium channel blockers among Filipinos.

Authors:  Felix Eduardo R Punzalan; Eva Maria C Cutiongco-de la Paz; Jose Jr B Nevado; Jose Donato A Magno; Deborah Ignacia D Ona; Aimee Yvonne Criselle L Aman; Marc Denver A Tiongson; Elmer Jasper B Llanes; Paul Ferdinand M Reganit; Richard Henry P Tiongco; Lourdes Ella G Santos; Jaime Alfonso M Aherrera; Lauro L Abrahan; Charlene F Agustin; Adrian John P Bejarin; Rody G Sy
Journal:  Medicine (Baltimore)       Date:  2022-02-04       Impact factor: 1.889

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.