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Literature DB >> 25603102

(Ubi)quitin' the h2bit: recent insights into the roles of H2B ubiquitylation in DNA replication and transcription.

Abstract

The reversible ubiquitylation of histone H2B has long been known to regulate gene transcription, and is now understood to modulate DNA replication as well. In this review, we describe how recent, genome-wide analyses have demonstrated that this histone mark has further reaching effects on transcription and replication than once thought. We also consider the ongoing efforts to elucidate the molecular mechanisms by which H2B ubiquitylation affects processes on the DNA template, and outline the various hypothetical scenarios.

Entities: Gene

Keywords: ARS, autonomous replication site; DNA replication; H2B ubiquitylation; H2Bub, monoubiquitylated H2B; HU, hydroxyurea; RNAP II, RNA Polymerase II; SAGA, Spt-Ada-Gcn5 acetyltransferase; chromatin; histone modification, transcription; ssDNA, single-stranded DNA

Mesh：

Substances：
Histones
DNA

Year: 2015 PMID： 25603102 PMCID： PMC4622827 DOI： 10.1080/15592294.2014.1003750

Source DB: PubMed Journal: Epigenetics ISSN： 1559-2294 Impact factor: 4.528

37 in total

1. Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1.

Authors: A Emili; D M Schieltz; J R Yates; L H Hartwell
Journal: Mol Cell Date: 2001-01 Impact factor: 17.970

2. Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels.

Authors: Mai Sun; Björn Schwalb; Nicole Pirkl; Kerstin C Maier; Arne Schenk; Henrik Failmezger; Achim Tresch; Patrick Cramer
Journal: Mol Cell Date: 2013-10-10 Impact factor: 17.970

3. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.

Authors: Arnaud R Krebs; Krishanpal Karmodiya; Marianne Lindahl-Allen; Kevin Struhl; Làszlò Tora
Journal: Mol Cell Date: 2011-11-04 Impact factor: 17.970

4. dNTP pools determine fork progression and origin usage under replication stress.

Authors: Jérôme Poli; Olga Tsaponina; Laure Crabbé; Andrea Keszthelyi; Véronique Pantesco; Andrei Chabes; Armelle Lengronne; Philippe Pasero
Journal: EMBO J Date: 2012-01-10 Impact factor: 11.598

Review 5. Chromatin modifiers and remodellers: regulators of cellular differentiation.

Authors: Taiping Chen; Sharon Y R Dent
Journal: Nat Rev Genet Date: 2013-12-24 Impact factor: 53.242

Review 6. Perceiving the epigenetic landscape through histone readers.

Authors: Catherine A Musselman; Marie-Eve Lalonde; Jacques Côté; Tatiana G Kutateladze
Journal: Nat Struct Mol Biol Date: 2012-12 Impact factor: 15.369

7. A role for H2B ubiquitylation in DNA replication.

Authors: Kelly M Trujillo; Mary Ann Osley
Journal: Mol Cell Date: 2012-10-25 Impact factor: 17.970

8. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

Authors: Efrat Shema-Yaacoby; Miroslav Nikolov; Mahmood Haj-Yahya; Peter Siman; Eric Allemand; Yuki Yamaguchi; Christian Muchardt; Henning Urlaub; Ashraf Brik; Moshe Oren; Wolfgang Fischle
Journal: Cell Rep Date: 2013-08-08 Impact factor: 9.423

(Ubi)quitin' the h2bit: recent insights into the roles of H2B ubiquitylation in DNA replication and transcription.

1. Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1.

2. Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels.

3. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.

4. dNTP pools determine fork progression and origin usage under replication stress.

Review 5. Chromatin modifiers and remodellers: regulators of cellular differentiation.

Review 6. Perceiving the epigenetic landscape through histone readers.

7. A role for H2B ubiquitylation in DNA replication.

8. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

9. Gene silencing: trans-histone regulatory pathway in chromatin.

10. Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.

1. Histone Modifications, Internucleosome Dynamics, and DNA Stresses: How They Cooperate to "Functionalize" Nucleosomes.

2. Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients.

3. Monoubiquitylation of histone H2B contributes to the bypass of DNA damage during and after DNA replication.

4. Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification.

5. Molecular Characterization, Expression Profiling, and SNP Analysis of the Porcine RNF20 Gene.

6. Effects of histone H2B ubiquitylation on the nucleosome structure and dynamics.