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Literature DB >> 23103252

A role for H2B ubiquitylation in DNA replication.

Abstract

The monoubiquitylation of histone H2B plays an important role in gene expression by contributing to the regulation of transcription elongation and mRNA processing and export. We explored additional cellular functions of this histone modification by investigating its localization to intergenic regions. H2B ubiquitylation is present in chromatin around origins of DNA replication in budding yeast, and as DNA is replicated its levels are maintained on daughter strands by the Bre1 ubiquitin ligase. In the absence of H2B ubiquitylation, the prereplication complex is formed and activated, but replication fork progression is slowed down and the replisome becomes unstable in the presence of hydroxyurea. H2B ubiquitylation promotes the assembly or stability of nucleosomes on newly replicated DNA, and this function is postulated to contribute to fork progression and replisome stability.

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Year: 2012 PMID： 23103252 PMCID： PMC3525772 DOI： 10.1016/j.molcel.2012.09.019

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

65 in total

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Review 3. Histone modifications during DNA replication.

Authors: Karina B Falbo; Xuetong Shen
Journal: Mol Cells Date: 2009-09-17 Impact factor: 5.034

Review 4. Restoring chromatin after replication: how new and old histone marks come together.

Authors: Zuzana Jasencakova; Anja Groth
Journal: Semin Cell Dev Biol Date: 2009-10-06 Impact factor: 7.727

5. Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.

Authors: Brett N Tomson; Christopher P Davis; Marcie H Warner; Karen M Arndt
Journal: Genetics Date: 2011-03-24 Impact factor: 4.562

6. All roads lead to chromatin: Multiple pathways for histone deposition.

Authors: Qing Li; Rebecca Burgess; Zhiguo Zhang
Journal: Biochim Biophys Acta Date: 2011-07-07

7. A role for Gcn5 in replication-coupled nucleosome assembly.

Authors: Rebecca J Burgess; Hui Zhou; Junhong Han; Zhiguo Zhang
Journal: Mol Cell Date: 2010-02-26 Impact factor: 17.970

8. A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.

Authors: Christine Zimmermann; Pierre Chymkowitch; Vegard Eldholm; Christopher D Putnam; Jessica M Lindvall; Manja Omerzu; Magnar Bjørås; Richard D Kolodner; Jorrit M Enserink
Journal: Proc Natl Acad Sci U S A Date: 2011-10-31 Impact factor: 11.205

9. Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.

Authors: Shima Nakanishi; Jung Shin Lee; Kathryn E Gardner; Jennifer M Gardner; Yoh-hei Takahashi; Mahesh B Chandrasekharan; Zu-Wen Sun; Mary Ann Osley; Brian D Strahl; Sue L Jaspersen; Ali Shilatifard
Journal: J Cell Biol Date: 2009-08-10 Impact factor: 10.539

10. H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast.

Authors: Grace S Shieh; Chin-Hua Pan; Jia-Hong Wu; Yun-Ju Sun; Chia-Chang Wang; Wei-Chun Hsiao; Chia-Yeh Lin; Luh Tung; Tien-Hsien Chang; Alastair B Fleming; Cory Hillyer; Yi-Chen Lo; Shelley L Berger; Mary Ann Osley; Cheng-Fu Kao
Journal: BMC Genomics Date: 2011-12-22 Impact factor: 3.969

66 in total

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Authors: Yu Nakabayashi; Satoshi Kawashima; Takemi Enomoto; Masayuki Seki; Masami Horikoshi
Journal: Proc Natl Acad Sci U S A Date: 2013-12-27 Impact factor: 11.205

2. Generation of nonhydrolyzable ubiquitin-histone mimics.

Authors: Lindsey Long; Melonnie Furgason; Tingting Yao
Journal: Methods Date: 2014-07-23 Impact factor: 3.608

Review 3. (Ubi)quitin' the h2bit: recent insights into the roles of H2B ubiquitylation in DNA replication and transcription.

Authors: Duncan E Wright; Cheng-Fu Kao
Journal: Epigenetics Date: 2015-02-03 Impact factor: 4.528

4. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.

Authors: Mark A McCormick; Amanda G Mason; Stephan J Guyenet; Weiwei Dang; Renee M Garza; Marc K Ting; Rick M Moller; Shelley L Berger; Matt Kaeberlein; Lorraine Pillus; Albert R La Spada; Brian K Kennedy
Journal: Cell Rep Date: 2014-07-18 Impact factor: 9.423

5. Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans.

Authors: Delphine Albrecht; Johanna Ceschin; Jim Dompierre; Florian Gueniot; Benoît Pinson; Bertrand Daignan-Fornier
Journal: Genetics Date: 2016-10-05 Impact factor: 4.562