OBJECTIVES: Our aim was to examine the association between the extent of late gadolinium enhancement (LGE) at right ventricular insertion points (RVIP) and left ventricular (LV) functional parameters in patients with hypertrophic cardiomyopathy (HCM). METHODS: Sixty-one HCM patients underwent echocardiography and cardiovascular magnetic resonance (CMR) within one week. Mitral annular velocities (E/E') were obtained from echocardiography; LV ejection fraction (EF), LV mass index, LV wall maximal thickness, and left atrial volume index (LAVI) were obtained from MR. LGE extent was quantified (proportion of total LV myocardial mass) according to location: % RVIP-LGE and % non-RVIP-LGE. RESULTS: Although LGE was commonly present in both apical (74 %) and non-apical HCMs (88 %) (p = 0.163), RVIP-LGE was more frequent (86 % vs. 47 %, p = 0.002) in non-apical HCMs in which E/E' was significantly higher (19.23 ± 8.40 vs. 13.13 ± 5.06, p = 0.009). In addition, RVIP-LGE extent was associated with LV diastolic dysfunction (r = 0.45, p < 0.001 for E/E'; r = 0.53, p < 0.001 for LAVI) and lower LVEF (r = -0.42, p = 0.001). There was no correlation between non-RVIP-LGE extent and other parameters. Multiple linear regression analysis revealed RVIP-LGE extent as an independent predictor of E/E' (β = 0.45, p < 0.001) and LAVI in HCM patients (β = 0.53, p < 0.001). CONCLUSIONS: The extent of LGE at RVIPs in HCM patients is associated with increased estimated LV filling pressure and chronic diastolic burden. KEY POINTS: • Late gadolinium enhancement at RV insertion points is frequently seen in HCM. • RVIP-LGE extent is correlated with increased estimated LV filling pressure in HCM. • Non-RVIP-LGE extent did not show any association with LV diastolic dysfunction.
OBJECTIVES: Our aim was to examine the association between the extent of late gadolinium enhancement (LGE) at right ventricular insertion points (RVIP) and left ventricular (LV) functional parameters in patients with hypertrophic cardiomyopathy (HCM). METHODS: Sixty-one HCM patients underwent echocardiography and cardiovascular magnetic resonance (CMR) within one week. Mitral annular velocities (E/E') were obtained from echocardiography; LV ejection fraction (EF), LV mass index, LV wall maximal thickness, and left atrial volume index (LAVI) were obtained from MR. LGE extent was quantified (proportion of total LV myocardial mass) according to location: % RVIP-LGE and % non-RVIP-LGE. RESULTS: Although LGE was commonly present in both apical (74 %) and non-apical HCMs (88 %) (p = 0.163), RVIP-LGE was more frequent (86 % vs. 47 %, p = 0.002) in non-apical HCMs in which E/E' was significantly higher (19.23 ± 8.40 vs. 13.13 ± 5.06, p = 0.009). In addition, RVIP-LGE extent was associated with LV diastolic dysfunction (r = 0.45, p < 0.001 for E/E'; r = 0.53, p < 0.001 for LAVI) and lower LVEF (r = -0.42, p = 0.001). There was no correlation between non-RVIP-LGE extent and other parameters. Multiple linear regression analysis revealed RVIP-LGE extent as an independent predictor of E/E' (β = 0.45, p < 0.001) and LAVI in HCM patients (β = 0.53, p < 0.001). CONCLUSIONS: The extent of LGE at RVIPs in HCM patients is associated with increased estimated LV filling pressure and chronic diastolic burden. KEY POINTS: • Late gadolinium enhancement at RV insertion points is frequently seen in HCM. • RVIP-LGE extent is correlated with increased estimated LV filling pressure in HCM. • Non-RVIP-LGE extent did not show any association with LV diastolic dysfunction.
Authors: S R Ommen; R A Nishimura; C P Appleton; F A Miller; J K Oh; M M Redfield; A J Tajik Journal: Circulation Date: 2000-10-10 Impact factor: 29.690
Authors: Kevin G Blyth; Bjoern A Groenning; Thomas N Martin; John E Foster; Patrick B Mark; Henry J Dargie; Andrew J Peacock Journal: Eur Heart J Date: 2005-05-17 Impact factor: 29.983
Authors: Martin S Maron; Evan Appelbaum; Caitlin J Harrigan; Jacki Buros; C Michael Gibson; Connie Hanna; John R Lesser; James E Udelson; Warren J Manning; Barry J Maron Journal: Circ Heart Fail Date: 2008-06-23 Impact factor: 8.790
Authors: B J Maron; I Olivotto; P Spirito; S A Casey; P Bellone; T E Gohman; K J Graham; D A Burton; F Cecchi Journal: Circulation Date: 2000-08-22 Impact factor: 29.690
Authors: Oliver Bruder; Anja Wagner; Christoph J Jensen; Steffen Schneider; Peter Ong; Eva-Maria Kispert; Kai Nassenstein; Thomas Schlosser; Georg V Sabin; Udo Sechtem; Heiko Mahrholdt Journal: J Am Coll Cardiol Date: 2010-06-25 Impact factor: 24.094
Authors: Benjamin H Freed; Mardi Gomberg-Maitland; Sonal Chandra; Victor Mor-Avi; Stuart Rich; Stephen L Archer; E Bruce Jamison; Roberto M Lang; Amit R Patel Journal: J Cardiovasc Magn Reson Date: 2012-02-01 Impact factor: 5.364
Authors: Christian Voigt; Julia Münch; Maxim Avanesov; Anna Suling; Katrin Witzel; Gunnar Lund; Monica Patten Journal: Clin Cardiol Date: 2017-07-24 Impact factor: 2.882
Authors: Fritz C Roller; Christoph Wiedenroth; Andreas Breithecker; Christoph Liebetrau; Eckhard Mayer; Christian Schneider; Andreas Rolf; Christian Hamm; Gabriele A Krombach Journal: Eur Radiol Date: 2016-09-20 Impact factor: 5.315
Authors: Anna M Price; Manvir K Hayer; Ravi Vijapurapu; Saad A Fyyaz; William E Moody; Charles J Ferro; Jonathan N Townend; Richard P Steeds; Nicola C Edwards Journal: BMC Cardiovasc Disord Date: 2019-12-16 Impact factor: 2.298