Ahmad Bitarafan-Rajabi1, Hossein Rajabi2, Feridoon Rastgou3, Hasan Firoozabady4, Nahid Yaghoobi4, Hadi Malek4, Werner Langesteger5, Mohsen Beheshti5. 1. Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran. bitarafan@hotmail.com. 2. Department of Medical Physics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran. 3. Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran. monami_58@yahoo.co.uk. 4. Department of Nuclear Medicine, Rajaie Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Nuclear Medicine & Endocrinology, St Vincent's Hospital, PET - CT Center Linz, Seilerstaette 4, Linz, A-4020, Austria.
Abstract
BACKGROUND: Respiratory-related cardiac motion could have considerable effects on myocardial perfusion imaging, leading to misinterpretation of the images. In this study, we examined the influence of respiratory correction on ECG-gated myocardial perfusion SPECT (RC-GSPECT) concerning regional myocardial perfusion and function. MATERIALS AND METHODS: Using the NCAT phantom, a typical torso phantom was generated. SimSET, a Monte Carlo simulator, was used to image the photon emerging from the phantom. Twenty-six patients underwent a 2-day stress-rest ECG-gated myocardial perfusion SPECT (GSPECT) imaging. A separate study was also performed by simultaneous respiratory and cardiac triggering with the real-time position management (RPM) for respiratory correction (RC). RESULTS: In simulation study, count density in the inferior and inferoseptal walls increased in the lower bin of the respiratory cycle. On the other hand, there was a higher correlation between RC-GSPECT and echocardiography for left ventricular ejection fraction (LVEF) (r = 0.95, P < .01 vs r = 0.88, P < .01 for GSPECT). CONCLUSION: We proposed a new approach for respiratory and cardiac-gated SPECT to eliminate respiratory motion artifacts. RC-GSPECT is a feasible method in MPI studies and may play an important role to improve the quality of MPI images, particularly in the inferior wall.
BACKGROUND: Respiratory-related cardiac motion could have considerable effects on myocardial perfusion imaging, leading to misinterpretation of the images. In this study, we examined the influence of respiratory correction on ECG-gated myocardial perfusion SPECT (RC-GSPECT) concerning regional myocardial perfusion and function. MATERIALS AND METHODS: Using the NCAT phantom, a typical torso phantom was generated. SimSET, a Monte Carlo simulator, was used to image the photon emerging from the phantom. Twenty-six patients underwent a 2-day stress-rest ECG-gated myocardial perfusion SPECT (GSPECT) imaging. A separate study was also performed by simultaneous respiratory and cardiac triggering with the real-time position management (RPM) for respiratory correction (RC). RESULTS: In simulation study, count density in the inferior and inferoseptal walls increased in the lower bin of the respiratory cycle. On the other hand, there was a higher correlation between RC-GSPECT and echocardiography for left ventricular ejection fraction (LVEF) (r = 0.95, P < .01 vs r = 0.88, P < .01 for GSPECT). CONCLUSION: We proposed a new approach for respiratory and cardiac-gated SPECT to eliminate respiratory motion artifacts. RC-GSPECT is a feasible method in MPI studies and may play an important role to improve the quality of MPI images, particularly in the inferior wall.
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