Alison J Athey1, Jason A Elias2, Jesse M Crosby3, Michael A Jenike2, Harrison G Pope4, James I Hudson4, Brian P Brennan5. 1. Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA. 2. Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA. 3. Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA. 4. Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA. 5. Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA ; Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA.
Abstract
OBJECTIVES: Disgust is a well-established phenomenon with known neurobiological correlates. However, it remains unclear how or whether disgust changes with clinical treatment, because few longitudinal studies have tracked the association of disgust vulnerability and clinical symptoms in patient populations. METHODS: We assessed disgust propensity and symptoms of obsessive-compulsive disorder (OCD) in 134 patients receiving intensive residential treatment for OCD. Using linear regression with adjustment for age, sex, and depression severity, we tested the association between change in disgust propensity and change in OCD symptoms from admission to discharge. RESULTS: Change in disgust propensity was significantly associated with improvement in contamination/washing symptoms (β = 0.25 [95% confidence interval: 0.11-0.39]; P = .001). No significant association was found between change in disgust propensity and change in other OCD symptom dimensions. CONCLUSIONS: In patients with OCD undergoing intensive residential treatment, disgust propensity appears to improve in parallel with contamination/washing symptoms.
OBJECTIVES: Disgust is a well-established phenomenon with known neurobiological correlates. However, it remains unclear how or whether disgust changes with clinical treatment, because few longitudinal studies have tracked the association of disgust vulnerability and clinical symptoms in patient populations. METHODS: We assessed disgust propensity and symptoms of obsessive-compulsive disorder (OCD) in 134 patients receiving intensive residential treatment for OCD. Using linear regression with adjustment for age, sex, and depression severity, we tested the association between change in disgust propensity and change in OCD symptoms from admission to discharge. RESULTS: Change in disgust propensity was significantly associated with improvement in contamination/washing symptoms (β = 0.25 [95% confidence interval: 0.11-0.39]; P = .001). No significant association was found between change in disgust propensity and change in other OCD symptom dimensions. CONCLUSIONS: In patients with OCD undergoing intensive residential treatment, disgust propensity appears to improve in parallel with contamination/washing symptoms.
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