BACKGROUND: There is growing interest in the role of disgust in the pathogenesis of obsessive-compulsive disorder (OCD). METHODS: Eight OCD subjects with contamination preoccupations and eight gender- and age-matched healthy volunteers viewed pictures from the International Affective Picture System during functional magnetic resonance imaging scans. RESULTS: A different distribution of brain activations was found during disgust-inducing visual stimulation in several areas, most notably the insula, compared with neutral stimulation in both OCD subjects and healthy volunteers. Furthermore, whereas activation during the threat-inducing task in OCD subjects showed a pattern similar to that in healthy volunteers, the pattern of activation during the disgust-inducing task was significantly different, including greater increases in the right insula, parahippocampal region, and inferior frontal sites. CONCLUSIONS: This pilot study supports the relevance of disgust in the neurocircuitry of OCD with contamination-preoccupation symptoms; future studies looking at non-OCD individuals with high disgust ratings, non-contamination-preoccupied OCD individuals, and individuals with other anxiety disorders are needed.
BACKGROUND: There is growing interest in the role of disgust in the pathogenesis of obsessive-compulsive disorder (OCD). METHODS: Eight OCD subjects with contamination preoccupations and eight gender- and age-matched healthy volunteers viewed pictures from the International Affective Picture System during functional magnetic resonance imaging scans. RESULTS: A different distribution of brain activations was found during disgust-inducing visual stimulation in several areas, most notably the insula, compared with neutral stimulation in both OCD subjects and healthy volunteers. Furthermore, whereas activation during the threat-inducing task in OCD subjects showed a pattern similar to that in healthy volunteers, the pattern of activation during the disgust-inducing task was significantly different, including greater increases in the right insula, parahippocampal region, and inferior frontal sites. CONCLUSIONS: This pilot study supports the relevance of disgust in the neurocircuitry of OCD with contamination-preoccupation symptoms; future studies looking at non-OCD individuals with high disgust ratings, non-contamination-preoccupied OCD individuals, and individuals with other anxiety disorders are needed.
Authors: Gail A Bernstein; Kathryn R Cullen; Elizabeth C Harris; Christine A Conelea; Alexandra D Zagoloff; Patricia A Carstedt; Susanne S Lee; Bryon A Mueller Journal: J Am Acad Child Adolesc Psychiatry Date: 2018-10-30 Impact factor: 8.829
Authors: Brian P Brennan; Danhong Wang; Meiling Li; Chris Perriello; Jianxun Ren; Jason A Elias; Nathaniel P Van Kirk; Jason W Krompinger; Harrison G Pope; Suzanne N Haber; Scott L Rauch; Justin T Baker; Hesheng Liu Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-08-16
Authors: Luca Cocchi; Ben J Harrison; Jesus Pujol; Ian H Harding; Alex Fornito; Christos Pantelis; Murat Yücel Journal: Hum Brain Mapp Date: 2011-05-24 Impact factor: 5.038
Authors: James F Leckman; Damiaan Denys; H Blair Simpson; David Mataix-Cols; Eric Hollander; Sanjaya Saxena; Euripedes C Miguel; Scott L Rauch; Wayne K Goodman; Katharine A Phillips; Dan J Stein Journal: Depress Anxiety Date: 2010-06 Impact factor: 6.505
Authors: Alison J Athey; Jason A Elias; Jesse M Crosby; Michael A Jenike; Harrison G Pope; James I Hudson; Brian P Brennan Journal: J Obsessive Compuls Relat Disord Date: 2015-01-01 Impact factor: 1.677