Esther Via1, Narcís Cardoner, Jesús Pujol, Pino Alonso, Marina López-Solà, Eva Real, Oren Contreras-Rodríguez, Joan Deus, Cinto Segalàs, José M Menchón, Carles Soriano-Mas, Ben J Harrison. 1. Esther Via, MD, Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain, and Melbourne Neuropsychiatry Centre, Department of Psychiatry & Melbourne Health, The University of Melbourne, National Neuroscience Facility, Melbourne, Australia; Narcís Cardoner, MD, PhD, Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain, Carlos III Health Institute, CIBERSAM, Spain and Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Jesús Pujol, MD, MRI Research Unit, CRC Mar, Hospital de Mar, Barcelona, Spain; Pino Alonso, MD, PhD, Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain, Carlos III Health Institute, CIBERSAM, Spain, and Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Marina López-Solà, PhD, MRI Research Unit, CRC Mar, Hospital de Mar, Barcelona, Spain and Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado, USA; Eva Real, MD, Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain and Carlos III Health Institute, CIBERSAM, Spain; Oren Contreras-Rodríguez, PhD, Carlos III Health Institute, CIBERSAM, Spain and MRI Research Unit, CRC Mar, Hospital de Mar, Barcelona, Spain; Joan Deus, PhD, MRI Research Unit, CRC Mar, Hospital de Mar, Barcelona, and Department of Clinical and Health Psychology, Autonomous University of Barcelona, Barcelona, Spain; Cinto Segalàs, MD, PhD, Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain, and Carlos III Health Institute, CIBERSAM, Spain; José M. Menchón, MD, PhD, Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain, Carlos III Health Institute, CIBERSAM, Spain, and Department of Clini
Abstract
BACKGROUND: Despite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology of obsessive-compulsive disorder (OCD) remains controversial. In the context of neuroimaging studies, it seems likely that the heterogeneity of the disorder might have contributed to a lack of consistent findings. AIMS: To assess the influence of OCD symptom dimensions on amygdala responses to a well-validated emotional face-matching paradigm. METHOD: Cross-sectional functional magnetic resonance imaging (fMRI) study of 67 patients with OCD and 67 age-, gender- and education-level matched healthy controls. RESULTS: The severity of aggression/checking and sexual/religious symptom dimensions were significantly associated with heightened amygdala activation in those with OCD when responding to fearful faces, whereas no such correlations were seen for other symptom dimensions. CONCLUSIONS: Amygdala functional alterations in OCD appear to be specifically modulated by symptom dimensions whose origins may be more closely linked to putative amygdala-centric processes, such as abnormal fear processing.
BACKGROUND: Despite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology of obsessive-compulsive disorder (OCD) remains controversial. In the context of neuroimaging studies, it seems likely that the heterogeneity of the disorder might have contributed to a lack of consistent findings. AIMS: To assess the influence of OCD symptom dimensions on amygdala responses to a well-validated emotional face-matching paradigm. METHOD: Cross-sectional functional magnetic resonance imaging (fMRI) study of 67 patients with OCD and 67 age-, gender- and education-level matched healthy controls. RESULTS: The severity of aggression/checking and sexual/religious symptom dimensions were significantly associated with heightened amygdala activation in those with OCD when responding to fearful faces, whereas no such correlations were seen for other symptom dimensions. CONCLUSIONS: Amygdala functional alterations in OCD appear to be specifically modulated by symptom dimensions whose origins may be more closely linked to putative amygdala-centric processes, such as abnormal fear processing.
Authors: Alison J Athey; Jason A Elias; Jesse M Crosby; Michael A Jenike; Harrison G Pope; James I Hudson; Brian P Brennan Journal: J Obsessive Compuls Relat Disord Date: 2015-01-01 Impact factor: 1.677
Authors: Clara López-Solà; Leonardo F Fontenelle; Brad Verhulst; Michael C Neale; José M Menchón; Pino Alonso; Ben J Harrison Journal: Depress Anxiety Date: 2015-12-02 Impact factor: 6.505
Authors: Marta Subirà; Marta Cano; Stella J de Wit; Pino Alonso; Narcís Cardoner; Marcelo Q Hoexter; Jun Soo Kwon; Takashi Nakamae; Christine Lochner; João R Sato; Wi Hoon Jung; Jin Narumoto; Dan J Stein; Jesus Pujol; David Mataix-Cols; Dick J Veltman; José M Menchón; Odile A van den Heuvel; Carles Soriano-Mas Journal: J Psychiatry Neurosci Date: 2016-03 Impact factor: 6.186
Authors: Maria Picó-Pérez; Jonathan Ipser; Paul Taylor; Pino Alonso; Clara López-Solà; Eva Real; Cinto Segalàs; Annerine Roos; José M Menchón; Dan J Stein; Carles Soriano-Mas Journal: Depress Anxiety Date: 2018-09-25 Impact factor: 6.505