Abigail Ness1, Jared Bruce2, Amanda Bruce3, Robin Aupperle1, Rebecca Lepping4, Laura Martin5, Laura Hancock1, Trisha Patrician6, Steve Malley7, Niazy Selim8, Cary R Savage9. 1. Department of Psychology, University of Missouri-Kansas City, Kansas City, Missouri. 2. Department of Psychology, University of Missouri-Kansas City, Kansas City, Missouri. Electronic address: brucejm@umkc.edu. 3. Department of Pediatrics, University of Kansas Medical Center and Children's Mercy Hospital, Kansas City, Missouri. 4. Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas. 5. Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas; Department of Preventive Medicine & Public Health, University of Kansas Medical Center, Kansas City, Kansas. 6. Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, Kansas. 7. Malley Surgical Weight Loss Center, Mission, Kansas. 8. Department of Endoscopic/Bariatric Surgery, University of Kansas Medical Center, Kansas City, Kansas. 9. Department of Preventive Medicine & Public Health, University of Kansas Medical Center, Kansas City, Kansas; Department of Psychiatry & Behavioral Sciences, University of Kansas Medical Center, Kansas City, Kansas.
Abstract
BACKGROUND: Recent research suggests that preintervention functional magnetic resonance imaging (fMRI) data may predict weight loss outcomes among patients who participate in a behavioral weight loss plan. No study has examined whether presurgical brain activation can predict outcomes following bariatric surgery. METHOD: The aim of the present study was to determine if brain activations during a presurgical fMRI food-motivation paradigm are associated with weight loss 3 and 6 months following laparoscopic adjustable gastric banding (LAGB). Nineteen participants viewed food and nonfood pictures from a well-established food motivation paradigm during an fMRI scanning session before LAGB surgery. Weight was assessed presurgery and 3 and 6 months postsurgery; data for all participants was available at each time point. fMRI data were analyzed using the BrainVoyager QX statistical package. Whole brain voxelwise correlations of presurgery (food-nonfood) brain activation and weight, corrected for multiple comparisons, were performed to analyze the relationship between presurgical brain activation and subsequent weight loss. The settings were a medical university brain imaging center and 2 surgical weight loss centers in a major metropolitan area. RESULTS: Increased activity in frontal regions associated with cognitive control (medial, middle, superior frontal gyrus) and posterior cingulate cortex was associated with weight loss following LAGB. CONCLUSION: We found that neural activity in previously established regions associated with cognitive and behavioral self-regulation predicts weight loss following bariatric surgery. These preliminary findings highlight the role of neural circuitry in the success and maintenance of weight loss and suggest a possible future use of fMRI in screening LAGB surgery candidates.
BACKGROUND: Recent research suggests that preintervention functional magnetic resonance imaging (fMRI) data may predict weight loss outcomes among patients who participate in a behavioral weight loss plan. No study has examined whether presurgical brain activation can predict outcomes following bariatric surgery. METHOD: The aim of the present study was to determine if brain activations during a presurgical fMRI food-motivation paradigm are associated with weight loss 3 and 6 months following laparoscopic adjustable gastric banding (LAGB). Nineteen participants viewed food and nonfood pictures from a well-established food motivation paradigm during an fMRI scanning session before LAGB surgery. Weight was assessed presurgery and 3 and 6 months postsurgery; data for all participants was available at each time point. fMRI data were analyzed using the BrainVoyager QX statistical package. Whole brain voxelwise correlations of presurgery (food-nonfood) brain activation and weight, corrected for multiple comparisons, were performed to analyze the relationship between presurgical brain activation and subsequent weight loss. The settings were a medical university brain imaging center and 2 surgical weight loss centers in a major metropolitan area. RESULTS: Increased activity in frontal regions associated with cognitive control (medial, middle, superior frontal gyrus) and posterior cingulate cortex was associated with weight loss following LAGB. CONCLUSION: We found that neural activity in previously established regions associated with cognitive and behavioral self-regulation predicts weight loss following bariatric surgery. These preliminary findings highlight the role of neural circuitry in the success and maintenance of weight loss and suggest a possible future use of fMRI in screening LAGB surgery candidates.
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