Panlong Li1,2,3, Han Shan4, Binbin Nie2,3, Hua Liu2,3, Guanglong Dong5, Yulin Guo5, Jin Du6, Hongkai Gao7, Lin Ma8, Demin Li9, Baoci Shan10,11,12. 1. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China. 2. Division of Nuclear Technology and Applications, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. 3. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China. 4. Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. 5. Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China. 6. Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China. 7. Department of General Surgery, The General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, China. 8. Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. cjr.malin@vip.163.com. 9. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China. lidm@zzu.edu.cn. 10. Division of Nuclear Technology and Applications, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. shanbc@mail.ihep.ac.cn. 11. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China. shanbc@mail.ihep.ac.cn. 12. CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China. shanbc@mail.ihep.ac.cn.
Abstract
BACKGROUND: Lateral and medial hypothalamus (LH and MH) play important roles in energy balance. Changed hypothalamic function has been found in subjects with obesity. However, the effect of bariatric surgery on the function of the two sub-regions has been poorly investigated. METHODS: Thirty-eight subjects with obesity and 34 age- and sex-matched normal-weight controls were included. Seventeen of the 38 subjects underwent laparoscopic sleeve gastrectomy. Functional magnetic resonance imaging data and metabolic parameters were collected to investigate functional connectivity networks of the two hypothalamic sub-regions as well as the influence of sleeve gastrectomy on the two networks in subjects with obesity. RESULTS: Compared to normal-weight controls, pre-surgical subjects had increased functional connectivity (FC) in the reward region (putamen) within the LH network, and increased FC in somatosensory cortical area (insula), as well as decreased FC in the cognitive control regions (prefrontal regions) within the MH network. After the surgery, post-surgical FC of the putamen within the LH network changed towards the patterns found in the control group. Furthermore, the changes in fasting glucose before and after the surgery were associated with the changes in FC of the putamen within the LH network. CONCLUSIONS: The FC within the LH and MH networks were changed in subjects with obesity. Part of these altered FC was rescued after the surgery.
BACKGROUND: Lateral and medial hypothalamus (LH and MH) play important roles in energy balance. Changed hypothalamic function has been found in subjects with obesity. However, the effect of bariatric surgery on the function of the two sub-regions has been poorly investigated. METHODS: Thirty-eight subjects with obesity and 34 age- and sex-matched normal-weight controls were included. Seventeen of the 38 subjects underwent laparoscopic sleeve gastrectomy. Functional magnetic resonance imaging data and metabolic parameters were collected to investigate functional connectivity networks of the two hypothalamic sub-regions as well as the influence of sleeve gastrectomy on the two networks in subjects with obesity. RESULTS: Compared to normal-weight controls, pre-surgical subjects had increased functional connectivity (FC) in the reward region (putamen) within the LH network, and increased FC in somatosensory cortical area (insula), as well as decreased FC in the cognitive control regions (prefrontal regions) within the MH network. After the surgery, post-surgical FC of the putamen within the LH network changed towards the patterns found in the control group. Furthermore, the changes in fasting glucose before and after the surgery were associated with the changes in FC of the putamen within the LH network. CONCLUSIONS: The FC within the LH and MH networks were changed in subjects with obesity. Part of these altered FC was rescued after the surgery.
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