Panlong Li1,2,3, Han Shan4, Shengxiang Liang1,2,3, Binbin Nie2,3, Hua Liu2,3, Shaofeng Duan2,3, Qi Huang2,3, Tianhao Zhang2,3, Guanglong Dong5, Yulin Guo5, Jin Du6, Hongkai Gao7, Lin Ma8, Demin Li9, Baoci Shan10,11,12,13. 1. Department of Physics, Zhengzhou University, Zhengzhou, Henan, 450001, China. 2. Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. 3. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing, 100049, China. 4. Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. 5. Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China. 6. Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China. 7. Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing, 100039, China. 8. Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. cjr.malin@vip.163.com. 9. Department of Physics, Zhengzhou University, Zhengzhou, Henan, 450001, China. lidm@zzu.edu.cn. 10. Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. shanbc@mail.ihep.ac.cn. 11. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing, 100049, China. shanbc@mail.ihep.ac.cn. 12. CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China. shanbc@mail.ihep.ac.cn. 13. Department of Physics, University of Chinese Academy of Sciences, Beijing, 100049, China. shanbc@mail.ihep.ac.cn.
Abstract
OBJECTIVE: Bariatric surgery could recover regional dysfunction of cerebral cortex. However, it is unknown whether bariatric surgery could recover the global-level dysfunction in subjects with obesity. The aim of this study was to investigate the effect of bariatric surgery on global-level dysfunction in subjects with obesity by resting-state functional magnetic resonance imaging (fMRI). METHODS: Resting-state fMRI was used to investigate dysfunction of whole-brain in 34 subjects with obesity and 34 age-and gender-matched normal-weight subjects, in which 17 subjects with obesity received sleeve gastrectomy. Fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) among the whole brain were used to estimate the brain functional differences among the preoperative subjects, postoperative subjects, and the controls. RESULTS: The preoperative subjects compared to controls had decreased resting-state activities in reward processing and cognitive control regions such as orbitofrontal cortex, middle frontal gyrus, superior frontal gyrus, and gyrus rectus. It was important that increased FC was also found in these regions. Correlation analysis showed that body mass index (BMI) was associated with these decreased activity and increased FC. More importantly, the dysfunction in these regions was recovered by the bariatric surgery. CONCLUSIONS: These results suggest that bariatric surgery-induced weight loss could reverse the global-level dysfunction in subjects with obesity. The dysfunction in these regions might play a key role in the development of obesity, which might serve as a biomarker in the treatment of obesity.
OBJECTIVE: Bariatric surgery could recover regional dysfunction of cerebral cortex. However, it is unknown whether bariatric surgery could recover the global-level dysfunction in subjects with obesity. The aim of this study was to investigate the effect of bariatric surgery on global-level dysfunction in subjects with obesity by resting-state functional magnetic resonance imaging (fMRI). METHODS: Resting-state fMRI was used to investigate dysfunction of whole-brain in 34 subjects with obesity and 34 age-and gender-matched normal-weight subjects, in which 17 subjects with obesity received sleeve gastrectomy. Fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) among the whole brain were used to estimate the brain functional differences among the preoperative subjects, postoperative subjects, and the controls. RESULTS: The preoperative subjects compared to controls had decreased resting-state activities in reward processing and cognitive control regions such as orbitofrontal cortex, middle frontal gyrus, superior frontal gyrus, and gyrus rectus. It was important that increased FC was also found in these regions. Correlation analysis showed that body mass index (BMI) was associated with these decreased activity and increased FC. More importantly, the dysfunction in these regions was recovered by the bariatric surgery. CONCLUSIONS: These results suggest that bariatric surgery-induced weight loss could reverse the global-level dysfunction in subjects with obesity. The dysfunction in these regions might play a key role in the development of obesity, which might serve as a biomarker in the treatment of obesity.
Entities:
Keywords:
Bariatric surgery; Brain; Functional connectivity; Magnetic resonance imaging; Obesity
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