Literature DB >> 2542941

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

J Colicelli1, C Birchmeier, T Michaeli, K O'Neill, M Riggs, M Wigler.   

Abstract

A rat brain cDNA library has been constructed in a Saccharomyces cerevisiae expression vector and used to isolate genes that can function in yeast to suppress the phenotypic effects of RAS2val19, a mutant form of the RAS2 gene analogous to an oncogenic mutant of the human HRAS gene. One cDNA, DPD, was cloned and its genetic and biochemical properties were characterized. A DPD product would share 80% amino acid sequence identity with the Drosophila melanogaster dunce-encoded protein over an extended region. We have shown that the DPD protein is a high-affinity cAMP-specific phosphodiesterase.

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Year:  1989        PMID： 2542941      PMCID： PMC287185          DOI： 10.1073/pnas.86.10.3599

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Calcium-dependent bacteriophage DNA infection.

Authors:  M Mandel; A Higa
Journal:  J Mol Biol       Date:  1970-10-14       Impact factor: 5.469

2.  A rapid boiling method for the preparation of bacterial plasmids.

Authors:  D S Holmes; M Quigley
Journal:  Anal Biochem       Date:  1981-06       Impact factor: 3.365

3.  Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

Authors:  R L Davis; H Takayasu; M Eberwine; J Myres
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

4.  Reward learning in normal and mutant Drosophila.

Authors:  B L Tempel; N Bonini; D R Dawson; W G Quinn
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

5.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

6.  Transformation of intact yeast cells treated with alkali cations.

Authors:  H Ito; Y Fukuda; K Murata; A Kimura
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

7.  The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase.

Authors:  J L Bennetzen; B D Hall
Journal:  J Biol Chem       Date:  1982-03-25       Impact factor: 5.157

8.  Studies on transformation of Escherichia coli with plasmids.

Authors:  D Hanahan
Journal:  J Mol Biol       Date:  1983-06-05       Impact factor: 5.469

9.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

10.  Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system.

Authors:  R L Davis; J A Kiger
Journal:  J Cell Biol       Date:  1981-07       Impact factor: 10.539
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  56 in total

1.  Transcriptional activating regions target a cyclin-dependent kinase.

Authors:  Aseem Z Ansari; Sang Seok Koh; Zafar Zaman; Christine Bongards; Norbert Lehming; Richard A Young; Mark Ptashne
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-04       Impact factor: 11.205

2.  A new screen for protein interactions reveals that the Saccharomyces cerevisiae high mobility group proteins Nhp6A/B are involved in the regulation of the GAL1 promoter.

Authors:  H Laser; C Bongards; J Schüller; S Heck; N Johnsson; N Lehming
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

3.  Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.

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Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-23       Impact factor: 11.205

Review 4.  Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

Authors:  T J Torphy; B J Undem
Journal:  Thorax       Date:  1991-07       Impact factor: 9.139

5.  Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein.

Authors:  Angela R Brannon; Julia A Maresca; Jef D Boeke; Munira A Basrai; Alison A McBride
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-14       Impact factor: 11.205

6.  Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae.

Authors:  R J Duronio; S I Reed; J I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

7.  Combination of two activating mutations in one HOG1 gene forms hyperactive enzymes that induce growth arrest.

Authors:  Gilad Yaakov; Michal Bell; Stefan Hohmann; David Engelberg
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

8.  Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

Authors:  J Colicelli; C Nicolette; C Birchmeier; L Rodgers; M Riggs; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

9.  Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.

Authors:  S J Elledge; J T Mulligan; S W Ramer; M Spottswood; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

10.  Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi.

Authors:  Maximiliano A D'Angelo; Santiago Sanguineti; Jeffrey M Reece; Lutz Birnbaumer; Héctor N Torres; Mirtha M Flawiá
Journal:  Biochem J       Date:  2004-02-15       Impact factor: 3.857
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