Literature DB >> 2541694

The effects of acute-phase inducers and dimethyl sulphoxide on delta-aminolaevulinate synthase activity in human HepG2 hepatoma cells.

F Iwasa1, S Sassa, A Kappas.   

Abstract

The effects of acute-phase inducers and dimethyl sulphoxide (Me2SO) on delta-aminolaevulinate (ALA) synthase in HepG2 cells were examined. Treatment of cells with Me2SO resulted in a significant increase in ALA synthase activity. Interleukin-6 increased ALA synthase activity only slightly, but it substantially potentiated the induction of ALA synthase by Me2SO. These data suggest that ALA synthase activity in liver is altered during acute-phase reactions.

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Year:  1989        PMID： 2541694      PMCID： PMC1138553          DOI： 10.1042/bj2590605

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Cytochrome p-450 heme and the regulation of delta-aminolevulinic acid synthetase in the liver.

Authors:  D M Bissell; L E Hammaker
Journal:  Arch Biochem Biophys       Date:  1976-09       Impact factor: 4.013

3.  Induction of haem synthesis in Hep G2 human hepatoma cells by dimethyl sulphoxide. A transcriptionally activated event.

Authors:  R A Galbraith; S Sassa; A Kappas
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

4.  Application of electroimmunoassay to the study of plasma protein synthesis in cultured hepatocytes.

Authors:  G Grieninger; J Pindyck; K M Hertzberg; M W Mosesson
Journal:  Ann Clin Lab Sci       Date:  1979 Nov-Dec       Impact factor: 1.256

Review 5.  P450 genes: structure, evolution, and regulation.

Authors:  D W Nebert; F J Gonzalez
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

6.  Radiochemical assay for gamma-aminolevulinate synthase.

Authors:  J D Brooker; G Srivastava; B K May; W H Elliott
Journal:  Enzyme       Date:  1982

7.  Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process.

Authors:  S Sassa; A Kappas
Journal:  J Biol Chem       Date:  1977-04-10       Impact factor: 5.157

8.  Are the decreases in hepatic cytochrome P-450 and other drug-metabolising enzymes caused by indomethacin in vivo mediated by intestinal bacterial endotoxins? 16,16-Dimethylprostaglandin F2 alpha prevents decreases in hepatic drug-metabolising enzymes due to exogenous endotoxin.

Authors:  M Falzon; A S Milton; M D Burke
Journal:  Biochem Pharmacol       Date:  1984-04-15       Impact factor: 5.858

9.  Effects of model traumatic injury on hepatic drug metabolism in the rat. I. In vivo antipyrine metabolism.

Authors:  L K Griffeth; G M Rosen; C Tschanz; E J Rauckman
Journal:  Drug Metab Dispos       Date:  1983 Nov-Dec       Impact factor: 3.922

10.  Delta-aminolevulinic acid dehydratase assay.

Authors:  S Sassa
Journal:  Enzyme       Date:  1982
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  4 in total

1.  Systemic inflammation in acute intermittent porphyria: a case-control study.

Authors:  E Storjord; J A Dahl; A Landsem; H Fure; J K Ludviksen; S Goldbeck-Wood; B O Karlsen; K S Berg; T E Mollnes; E W Nielsen; O-L Brekke
Journal:  Clin Exp Immunol       Date:  2016-12-15       Impact factor: 4.330

2.  Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis.

Authors:  Richard R Almon; Debra C DuBois; Emily H Brandenburg; Wei Shi; Shuzhong Zhang; Robert M Straubinger; William J Jusko
Journal:  J Pharmacokinet Pharmacodyn       Date:  2002-04       Impact factor: 2.745

3.  Dental and Periodontal Health in Acute Intermittent Porphyria.

Authors:  Elin Storjord; Stella Airila-Månsson; Katarzyna Karlsen; Martin Madsen; Jim André Dahl; Anne Landsem; Hilde Fure; Judith Krey Ludviksen; Johannes Østrem Fjøse; Amy K Dickey; Bård Ove Karlsen; Erik Waage Nielsen; Tom Eirik Mollnes; Ole-Lars Brekke
Journal:  Life (Basel)       Date:  2022-08-19

4.  Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.

Authors:  Abdulla A-B Badawy
Journal:  Biosci Rep       Date:  2021-07-30       Impact factor: 3.840
  4 in total

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