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Literature DB >> 25376893

MR imaging probes: design and applications.

Eszter Boros¹, Eric M Gale¹, Peter Caravan¹.

Abstract

This perspective outlines strategies towards the development of MR imaging probes that our lab has explored over the last 15 years. Namely, we discuss methods to enhance the signal generating capacity of MR probes and how to achieve tissue specificity through protein targeting or probe activation within the tissue microenvironment.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Proteins
Water

Year: 2015 PMID： 25376893 PMCID： PMC5155710 DOI： 10.1039/c4dt02958e

Source DB: PubMed Journal: Dalton Trans ISSN： 1477-9226 Impact factor: 4.390

127 in total

1. Multilocus binding increases the relaxivity of protein-bound MRI contrast agents.

Authors: Zhaoda Zhang; Matthew T Greenfield; Marga Spiller; Thomas J McMurry; Randall B Lauffer; Peter Caravan
Journal: Angew Chem Int Ed Engl Date: 2005-10-21 Impact factor: 15.336

2. Hyperpolarized xenon-based molecular sensors for label-free detection of analytes.

Authors: Praveena D Garimella; Tyler Meldrum; Leah S Witus; Monica Smith; Vikram S Bajaj; David E Wemmer; Matthew B Francis; Alexander Pines
Journal: J Am Chem Soc Date: 2013-12-18 Impact factor: 15.419

3. MR angiography of aortoiliac occlusive disease: a phase III study of the safety and effectiveness of the blood-pool contrast agent MS-325.

Authors: Mathias Goyen; Mark Edelman; Pierre Perreault; Elaine O'Riordan; Hernan Bertoni; James Taylor; Daniel Siragusa; Melhem Sharafuddin; Emile R Mohler; Robert Breger; E Kent Yucel; Kohkan Shamsi; Robert M Weisskoff
Journal: Radiology Date: 2005-07-14 Impact factor: 11.105

4. High relaxivity magnetic resonance imaging contrast agents. Part 1. Impact of single donor atom substitution on relaxivity of serum albumin-bound gadolinium complexes.

Authors: Stéphane Dumas; Vincent Jacques; Wei-Chuan Sun; Jeffrey S Troughton; Joel T Welch; Jaclyn M Chasse; Heribert Schmitt-Willich; Peter Caravan
Journal: Invest Radiol Date: 2010-10 Impact factor: 6.016

5. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.

Authors: John W Chen; Manel Querol Sans; Alexei Bogdanov; Ralph Weissleder
Journal: Radiology Date: 2006-08 Impact factor: 11.105

6. Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI.

Authors: Anna Tietze; Jakob Blicher; Irene Klaerke Mikkelsen; Leif Østergaard; Megan K Strother; Seth A Smith; Manus J Donahue
Journal: NMR Biomed Date: 2013-11-28 Impact factor: 4.044

7. Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

Authors: Yunkou Wu; Youfu Zhou; Olivier Ouari; Mark Woods; Piyu Zhao; Todd C Soesbe; Garry E Kiefer; A Dean Sherry
Journal: J Am Chem Soc Date: 2008-09-26 Impact factor: 15.419

8. Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI.

Authors: Kun Qing; Kai Ruppert; Yun Jiang; Jaime F Mata; G Wilson Miller; Y Michael Shim; Chengbo Wang; Iulian C Ruset; F William Hersman; Talissa A Altes; John P Mugler
Journal: J Magn Reson Imaging Date: 2013-05-16 Impact factor: 4.813

Review 9. Redox- and hypoxia-responsive MRI contrast agents.

Authors: Quyen N Do; James S Ratnakar; Zoltán Kovács; A Dean Sherry
Journal: ChemMedChem Date: 2014-05-13 Impact factor: 3.466

10. Thrombus imaging with fibrin-specific gadolinium-based MR contrast agent EP-2104R: results of a phase II clinical study of feasibility.

Authors: Josef Vymazal; Elmar Spuentrup; Gerardo Cardenas-Molina; Andrea J Wiethoff; Michael G Hartmann; Peter Caravan; Edward C Parsons
Journal: Invest Radiol Date: 2009-11 Impact factor: 6.016

37 in total

1. Free-base porphyrins as CEST MRI contrast agents with highly upfield shifted labile protons.

Authors: Xiaoxiao Zhang; Yaping Yuan; Sha Li; Qingbin Zeng; Qianni Guo; Na Liu; Minghui Yang; Yunhuang Yang; Maili Liu; Michael T McMahon; Xin Zhou
Journal: Magn Reson Med Date: 2019-04-10 Impact factor: 4.668

Review 2. Gadolinium-based contrast agents in pediatric magnetic resonance imaging.

Authors: Eric M Gale; Peter Caravan; Anil G Rao; Robert J McDonald; Matthew Winfeld; Robert J Fleck; Michael S Gee
Journal: Pediatr Radiol Date: 2017-04-13

3. Magnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents.

Authors: Soma Das; Kenia Parga; Indranil Chakraborty; Arthur D Tinoco; Yamixa Delgado; Paola M López; Lauren Fernández Vega; Yiannis Sanakis; Sukhen Ghosh; Jim Bankson; Jim Klostergaard; Ricardo González-Méndez; Raphael G Raptis
Journal: J Inorg Biochem Date: 2018-06-26 Impact factor: 4.155

4. Screening of ligands for redox-active europium using magnetic resonance imaging.

Authors: Brooke A Corbin; Lina A Basal; Susan A White; Yimin Shen; E Mark Haacke; Kenneth W Fishbein; Matthew J Allen
Journal: Bioorg Med Chem Date: 2018-04-04 Impact factor: 3.641

5. Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore.

Authors: Steven K Taylor; Timothy H Tran; Michael Z Liu; Paul E Harris; Yanping Sun; Sachin R Jambawalikar; Liang Tong; Milan N Stojanovic
Journal: Chemistry Date: 2018-07-04 Impact factor: 5.236

6. A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes.

Authors: Matthew W Rotz; Robert J Holbrook; Keith W MacRenaris; Thomas J Meade
Journal: Bioconjug Chem Date: 2018-10-10 Impact factor: 4.774