Literature DB >> 27960350

A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range.

Eric M Gale1, Chloe M Jones1, Ian Ramsay1, Christian T Farrar1, Peter Caravan1.   

Abstract

We introduce a new biochemically responsive Mn-based MRI contrast agent that provides a 9-fold change in relaxivity via switching between the Mn3+ and Mn2+ oxidation states. Interchange between oxidation states is promoted by a "Janus" ligand that isomerizes between binding modes that favor Mn3+ or Mn2+. It is the only ligand that supports stable complexes of Mn3+ and Mn2+ in biological milieu. Rapid interconversion between oxidation states is mediated by peroxidase activity (oxidation) and l-cysteine (reduction). This Janus system provides a new paradigm for the design of biochemically responsive MRI contrast agents.

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Year:  2016        PMID： 27960350      PMCID： PMC5328420          DOI： 10.1021/jacs.6b10898

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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