R Fornari1, D Francomano1, E A Greco1,2, C Marocco1, C Lubrano1, F Wannenes2,3, V Papa3, V M Bimonte2,3, L M Donini1, A Lenzi1, A Aversa1,2, S Migliaccio4. 1. Department Experimental Medicine, Section Medical Pathophysiology, Endocrinology and Nutrition, University "Sapienza" of Rome, Rome, Italy. 2. LiSa Laboratory, Azienda Ospedaliera-Universitaria "Policlinico Vittorio Emanuele", University of Catania, Catania, Italy. 3. Department of Movement, Human and Health Sciences, Section of Health Sciences, University "Foro Italico" of Rome, Largo Lauro De Bosis 15, 00195, Rome, Italy. 4. Department of Movement, Human and Health Sciences, Section of Health Sciences, University "Foro Italico" of Rome, Largo Lauro De Bosis 15, 00195, Rome, Italy. silvia.migliaccio@uniroma4.it.
Abstract
AIM: Several chronic metabolic alterations are present in obese subjects. While it is well known about the detrimental effect of abdominal adipose tissue on chronic metabolic clinical condition, less is known on the role of lean mass in obese subjects. Thus, the aim of our study was to evaluate the potential correlation of muscle mass, metabolic condition and inflammation status in obese individuals. METHODS: The study included 426 obese subjects (86 men and 340 female; mean age 44.8 ± 14 years; BMI: 34.9 ± 6.1 kg/m(2)). Exclusion criteria were chronic medical conditions or use of medications affecting bone metabolism, alterations of hormonal and nutritional status, vitamin D supplementation, recent weight loss and prior bariatric surgery. Patients underwent measurements of bone mineral density (lumbar and hip) and body composition (lean mass, total and trunk fat mass) by dual X-ray absorptiometry and were evaluated for hormonal and metabolic profile and inflammatory markers. RESULTS: Higher lean body mass (LM%) was inversely correlated with homeostasis model assessment of insulin resistance (p < 0.0091; r(2) 0.03938) and associated with lower fibrinogen levels (p < 0.0001; r(2) 0.1263). Interestingly, in obese subjects, LM% was associated with higher levels of vitamin D (p < 0.0001, r(2) 0.1140), osteocalcin (p < 0.0001, r(2) 0.2401) and insulin-like growth factor-1 (IGF-1) (p < 0.0002, r(2) 0.1367). CONCLUSION: Our results show for the first time that in obese patients, higher amounts of lean mass are directly linked to a lower inflammatory profile and to better insulin sensitivity, but also to the presence of higher level of vitamin D and IGF-1. Moreover, these data suggest that higher levels of lean mass in obese people correlate with a better metabolic profile and, thus, strongly suggest the need to develop programs to facilitate an increase in physical activity in obese people.
AIM: Several chronic metabolic alterations are present in obese subjects. While it is well known about the detrimental effect of abdominal adipose tissue on chronic metabolic clinical condition, less is known on the role of lean mass in obese subjects. Thus, the aim of our study was to evaluate the potential correlation of muscle mass, metabolic condition and inflammation status in obese individuals. METHODS: The study included 426 obese subjects (86 men and 340 female; mean age 44.8 ± 14 years; BMI: 34.9 ± 6.1 kg/m(2)). Exclusion criteria were chronic medical conditions or use of medications affecting bone metabolism, alterations of hormonal and nutritional status, vitamin D supplementation, recent weight loss and prior bariatric surgery. Patients underwent measurements of bone mineral density (lumbar and hip) and body composition (lean mass, total and trunk fat mass) by dual X-ray absorptiometry and were evaluated for hormonal and metabolic profile and inflammatory markers. RESULTS: Higher lean body mass (LM%) was inversely correlated with homeostasis model assessment of insulin resistance (p < 0.0091; r(2) 0.03938) and associated with lower fibrinogen levels (p < 0.0001; r(2) 0.1263). Interestingly, in obese subjects, LM% was associated with higher levels of vitamin D (p < 0.0001, r(2) 0.1140), osteocalcin (p < 0.0001, r(2) 0.2401) and insulin-like growth factor-1 (IGF-1) (p < 0.0002, r(2) 0.1367). CONCLUSION: Our results show for the first time that in obesepatients, higher amounts of lean mass are directly linked to a lower inflammatory profile and to better insulin sensitivity, but also to the presence of higher level of vitamin D and IGF-1. Moreover, these data suggest that higher levels of lean mass in obesepeople correlate with a better metabolic profile and, thus, strongly suggest the need to develop programs to facilitate an increase in physical activity in obesepeople.
Entities:
Keywords:
Inflammation; Muscle; Obesity; Vitamin D
Authors: J L Clasey; A Weltman; J Patrie; J Y Weltman; S Pezzoli; C Bouchard; M O Thorner; M L Hartman Journal: J Clin Endocrinol Metab Date: 2001-08 Impact factor: 5.958
Authors: E A Greco; R Fornari; F Rossi; V Santiemma; G Prossomariti; C Annoscia; A Aversa; M Brama; M Marini; L M Donini; G Spera; A Lenzi; C Lubrano; S Migliaccio Journal: Int J Clin Pract Date: 2010-05 Impact factor: 2.503
Authors: Silvia Migliaccio; Davide Francomano; Roberto Bruzziches; Emanuela A Greco; Rachele Fornari; Lorenzo M Donini; Andrea Lenzi; Antonio Aversa Journal: Int J Endocrinol Date: 2013-11-20 Impact factor: 3.257
Authors: S Salekzamani; H Mehralizadeh; A Ghezel; Y Salekzamani; M A Jafarabadi; A S Bavil; B P Gargari Journal: J Endocrinol Invest Date: 2016-07-11 Impact factor: 4.256
Authors: Brandon S Klinedinst; Colleen Pappas; Scott Le; Shan Yu; Qian Wang; Li Wang; Karin Allenspach-Jorn; Jonathan P Mochel; Auriel A Willette Journal: Brain Behav Immun Date: 2019-09-09 Impact factor: 7.217
Authors: A B Crujeiras; B Cabia; M C Carreira; M Amil; J Cueva; S Andrade; L M Seoane; M Pardo; A Sueiro; J Baltar; T Morais; M P Monteiro; R Lopez-Lopez; F F Casanueva Journal: Int J Obes (Lond) Date: 2015-10-26 Impact factor: 5.095