Literature DB >> 26353882

Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review.

Louise Wamberg1, Steen B Pedersen2, Lars Rejnmark3, Bjørn Richelsen4.   

Abstract

Obese subjects are often characterized by low plasma 25-hydroxy-vitamin D (25OHD) levels. Many explanations for this association have been proposed. Low plasma 25OHD is associated with obesity-related comorbidities such as insulin resistance, type 2 diabetes mellitus, and low-grade inflammation. In this review, we discuss the proposed mechanisms for low 25OHD in obesity and explore the results of recent RCTs on vitamin D (VD) supplementation on obesity and its metabolic complications such as insulin resistance and type 2 diabetes. Although the results from these clinical randomized controlled trials vary, the general picture is that VD treatment of obese individuals does not seem to be an effective treatment of obesity-related metabolic complications.

Entities:  

Keywords:  Adipose tissue; Inflammation; Insulin resistance; Obesity; Review; Vitamin D

Mesh：

Substances：

Year:  2015        PMID： 26353882     DOI： 10.1007/s13679-015-0176-5

Source DB:  PubMed          Journal:  Curr Obes Rep        ISSN： 2162-4968


  135 in total

Review 1.  Inflammation and metabolic disorders.

Authors:  Gökhan S Hotamisligil
Journal:  Nature       Date:  2006-12-14       Impact factor: 49.962

2.  Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes.

Authors:  Sakineh Shab-Bidar; Tirang R Neyestani; Abolghassem Djazayery; Mohammad-Reza Eshraghian; Anahita Houshiarrad; Ali Kalayi; Nastaran Shariatzadeh; Niloufar Khalaji; A'azam Gharavi
Journal:  Diabetes Metab Res Rev       Date:  2012-02-17       Impact factor: 4.876

3.  Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme.

Authors:  M J Beckman; P Tadikonda; E Werner; J Prahl; S Yamada; H F DeLuca
Journal:  Biochemistry       Date:  1996-06-25       Impact factor: 3.162

4.  Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease.

Authors:  Giovanni Targher; Lorenzo Bertolini; Luca Scala; Massimo Cigolini; Luciano Zenari; Giancarlo Falezza; Guido Arcaro
Journal:  Nutr Metab Cardiovasc Dis       Date:  2006-08-22       Impact factor: 4.222

5.  Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo.

Authors:  C Cade; A W Norman
Journal:  Endocrinology       Date:  1986-07       Impact factor: 4.736

6.  Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994-95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up.

Authors:  G Grimnes; N Emaus; R M Joakimsen; Y Figenschau; T Jenssen; I Njølstad; H Schirmer; R Jorde
Journal:  Diabet Med       Date:  2010-10       Impact factor: 4.359

Review 7.  Adipose tissue, inflammation, and cardiovascular disease.

Authors:  Anders H Berg; Philipp E Scherer
Journal:  Circ Res       Date:  2005-05-13       Impact factor: 17.367

8.  Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction.

Authors:  Ken C Chiu; Audrey Chu; Vay Liang W Go; Mohammed F Saad
Journal:  Am J Clin Nutr       Date:  2004-05       Impact factor: 7.045

9.  25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey.

Authors:  Jessica Kendrick; Giovanni Targher; Gerard Smits; Michel Chonchol
Journal:  Atherosclerosis       Date:  2008-11-11       Impact factor: 5.162

10.  25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women.

Authors:  Sibel Ertek; Ebru Akgül; Arrigo F Cicero; Utku Kütük; Selda Demirtaş; Sengül Cehreli; Gürbüz Erdoğan
Journal:  Arch Med Sci       Date:  2012-02-29       Impact factor: 3.318
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  18 in total

Review 1.  Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism.

Authors:  Stefania Giuliana Garbossa; Franco Folli
Journal:  Rev Endocr Metab Disord       Date:  2017-06       Impact factor: 6.514

2.  Vitamin D levels in a population from Argentina with metabolic disorders.

Authors:  Maria Constanza Luciardi; Mariano Nicolás Alemán; Daniela Martinez; Mirta Centeno Maxzud; Analía Soria; Mirta Ester Aldonati; Hector Lucas Luciardi
Journal:  Porto Biomed J       Date:  2022-06-17

3.  Low Vitamin D Levels Do Not Predict Hyperglycemia in Elderly Endurance Athletes (but in Controls).

Authors:  Helmuth Haslacher; Sonja Nistler; Delgerdalai Batmyagmar; Elisabeth Ponocny-Seliger; Thomas Perkmann; Thomas M Scherzer; Michael Kundi; Georg Endler; Franz Ratzinger; Alexander Pilger; Oswald F Wagner; Robert Winker
Journal:  PLoS One       Date:  2016-06-15       Impact factor: 3.240

4.  Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men-a randomized controlled trial.

Authors:  Christos Karefylakis; Stefan Särnblad; Annaclara Ariander; Gustaf Ehlersson; Eva Rask; Peter Rask
Journal:  Endocrine       Date:  2018-07-05       Impact factor: 3.633

5.  A preliminary transcriptome analysis suggests a transitory effect of vitamin D on mitochondrial function in obese young Finnish subjects.

Authors:  Elisabet Einarsdottir; Minna Pekkinen; Kaarel Krjutškov; Shintaro Katayama; Juha Kere; Outi Mäkitie; Heli Viljakainen
Journal:  Endocr Connect       Date:  2019-05-01       Impact factor: 3.335

6.  Effects of vitamin D supplementation on insulin resistance and dyslipidemia in overweight and obese premenopausal women.

Authors:  Narin Nasiroglu Imga; Alper Cagri Karci; Dilek Oztas; Dilek Berker; Serdar Guler
Journal:  Arch Med Sci       Date:  2018-05-21       Impact factor: 3.318

Review 7.  Vitamin D Deficiency: Consequence or Cause of Obesity?

Authors:  Luka Vranić; Ivana Mikolašević; Sandra Milić
Journal:  Medicina (Kaunas)       Date:  2019-08-28       Impact factor: 2.430

8.  Obesity and 25(OH)D Serum Concentration Are More Important than Vitamin D Intake for Changes in Nutritional Status Indicators: A Population-Based Longitudinal Study in a State Capital City in Southern Brazil.

Authors:  Francieli Cembranel; Eleonora d'Orsi; Katia Jakovljevic Pudla Wagner; Marui Weber Corseuil Giehl; Yara Maria Franco Moreno; David Alejandro González-Chica
Journal:  Nutrients       Date:  2019-10-04       Impact factor: 5.717

9.  Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Authors:  Laine de Carvalho Guerra Pessoa Mamede; Rafaela Lira Formiga Cavalcanti de Lima; Alexandre Sérgio Silva; João Carlos Lima Rodrigues Pita; Nadjeanny Ingrid Galdino Gomes; Elisama Araújo de Sena; Rhayra Priscila Moraes Nobrega; João Otávio Scarano Alcântara; Julie Hanna Fontes de Souza; Glêbia Alexa Cardoso; José Luiz de Brito Alves; Maria da Conceição Rodrigues Gonçalves
Journal:  Diabetes Metab Syndr Obes       Date:  2021-02-04       Impact factor: 3.168

10.  Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency.

Authors:  Sushil K Jain; Rajesh Parsanathan; Arunkumar E Achari; Preeti Kanikarla-Marie; Joseph A Bocchini
Journal:  Antioxid Redox Signal       Date:  2018-10-09       Impact factor: 8.401
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