Ricardo A Battaglino1, Nguyen Nguyen1, Megan Summers2, Leslie R Morse3. 1. Department of Rehabilitation Medicine, University of Minnesota School of Medicine, University of Minnesota Medical School, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, USA. 2. Pulmonary Division, Department of Medicine, National Jewish Health, Denver, CO, USA. 3. Department of Rehabilitation Medicine, University of Minnesota School of Medicine, University of Minnesota Medical School, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, USA. Morsel@umn.edu.
Abstract
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury. SETTING: Veteran Affairs Medical Center. METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model. RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r2 = 0.58). CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury. SETTING: Veteran Affairs Medical Center. METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model. RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r2 = 0.58). CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.
Authors: Anne L Schafer; Deborah E Sellmeyer; Ann V Schwartz; Clifford J Rosen; Eric Vittinghoff; Lisa Palermo; John P Bilezikian; Dolores M Shoback; Dennis M Black Journal: J Clin Endocrinol Metab Date: 2011-10-12 Impact factor: 5.958
Authors: Jose Manuel Fernández-Real; Mikel Izquierdo; Francisco Ortega; Esteban Gorostiaga; Javier Gómez-Ambrosi; Jose Maria Moreno-Navarrete; Gema Frühbeck; Cristina Martínez; Fernando Idoate; Javier Salvador; Lluis Forga; Wifredo Ricart; Javier Ibañez Journal: J Clin Endocrinol Metab Date: 2008-10-14 Impact factor: 5.958
Authors: Fernanda G Basso; Ana Paula Silveira Turrioni; Josimeri Hebling; Carlos A de Souza Costa Journal: Gerontology Date: 2013-07-18 Impact factor: 5.140
Authors: Xuzhu Lin; Erik Hanson; Andrew C Betik; Tara C Brennan-Speranza; Alan Hayes; Itamar Levinger Journal: J Bone Miner Res Date: 2016-07-05 Impact factor: 6.741