Literature DB >> 25347991

Deep and quantitative top-down proteomics in clinical and translational research.

Neil L Kelleher1, Paul M Thomas, Ioanna Ntai, Philip D Compton, Richard D LeDuc.   

Abstract

It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

Entities:  

Keywords:  clinical; proteomics; quantitative; top-down; translational

Mesh：

Substances：

Year:  2014        PMID： 25347991      PMCID： PMC4295490          DOI： 10.1586/14789450.2014.976559

Source DB:  PubMed          Journal:  Expert Rev Proteomics        ISSN： 1478-9450            Impact factor:   3.940


  17 in total

Review 1.  Decoding protein modifications using top-down mass spectrometry.

Authors:  Nertila Siuti; Neil L Kelleher
Journal:  Nat Methods       Date:  2007-10       Impact factor: 28.547

2.  Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Authors:  Adam D Catherman; Kenneth R Durbin; Dorothy R Ahlf; Bryan P Early; Ryan T Fellers; John C Tran; Paul M Thomas; Neil L Kelleher
Journal:  Mol Cell Proteomics       Date:  2013-09-10       Impact factor: 5.911

3.  iProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates.

Authors:  David Shteynberg; Eric W Deutsch; Henry Lam; Jimmy K Eng; Zhi Sun; Natalie Tasman; Luis Mendoza; Robert L Moritz; Ruedi Aebersold; Alexey I Nesvizhskii
Journal:  Mol Cell Proteomics       Date:  2011-08-29       Impact factor: 5.911

4.  Proteoform: a single term describing protein complexity.

Authors:  Lloyd M Smith; Neil L Kelleher
Journal:  Nat Methods       Date:  2013-03       Impact factor: 28.547

5.  Compound heterozygotes and beta-thalassemia: top-down mass spectrometry for detection of hemoglobinopathies.

Authors:  Rebecca L Edwards; Paul Griffiths; Josephine Bunch; Helen J Cooper
Journal:  Proteomics       Date:  2014-03-07       Impact factor: 3.984

6.  Quantitative analysis of human salivary gland-derived intact proteome using top-down mass spectrometry.

Authors:  Si Wu; Joseph N Brown; Nikola Tolić; Da Meng; Xiaowen Liu; Haizhen Zhang; Rui Zhao; Ronald J Moore; Pavel Pevzner; Richard D Smith; Ljiljana Paša-Tolić
Journal:  Proteomics       Date:  2014-04-13       Impact factor: 3.984

7.  Primate transcript and protein expression levels evolve under compensatory selection pressures.

Authors:  Zia Khan; Michael J Ford; Darren A Cusanovich; Amy Mitrano; Jonathan K Pritchard; Yoav Gilad
Journal:  Science       Date:  2013-10-17       Impact factor: 47.728

Review 8.  Mass spectrometry-based proteomics in cell biology.

Authors:  Tobias C Walther; Matthias Mann
Journal:  J Cell Biol       Date:  2010-08-23       Impact factor: 10.539

9.  The C-score: a Bayesian framework to sharply improve proteoform scoring in high-throughput top down proteomics.

Authors:  Richard D LeDuc; Ryan T Fellers; Bryan P Early; Joseph B Greer; Paul M Thomas; Neil L Kelleher
Journal:  J Proteome Res       Date:  2014-06-12       Impact factor: 4.466

10.  Characterization of salivary proteins of schizophrenic and bipolar disorder patients by top-down proteomics.

Authors:  Federica Iavarone; Marianna Melis; Giovanna Platania; Tiziana Cabras; Barbara Manconi; Raffaele Petruzzelli; Massimo Cordaro; Alberto Siracusano; Gavino Faa; Irene Messana; Marco Zanasi; Massimo Castagnola
Journal:  J Proteomics       Date:  2014-03-30       Impact factor: 4.044
View more
  13 in total

1.  Simultaneous Quantification of Protein Expression and Modifications by Top-down Targeted Proteomics: A Case of the Sarcomeric Subproteome.

Authors:  Ziqing Lin; Liming Wei; Wenxuan Cai; Yanlong Zhu; Trisha Tucholski; Stanford D Mitchell; Wei Guo; Stephen P Ford; Gary M Diffee; Ying Ge
Journal:  Mol Cell Proteomics       Date:  2018-12-27       Impact factor: 5.911

2.  Online Hydrophobic Interaction Chromatography-Mass Spectrometry for Top-Down Proteomics.

Authors:  Bifan Chen; Ying Peng; Santosh G Valeja; Lichen Xiu; Andrew J Alpert; Ying Ge
Journal:  Anal Chem       Date:  2016-01-14       Impact factor: 6.986

3.  Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics.

Authors:  Santosh G Valeja; Lichen Xiu; Zachery R Gregorich; Huseyin Guner; Song Jin; Ying Ge
Journal:  Anal Chem       Date:  2015-04-29       Impact factor: 6.986

4.  Detection of Isoforms Differing by a Single Charge Unit in Individual Cells.

Authors:  Augusto M Tentori; Kevin A Yamauchi; Amy E Herr
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-06       Impact factor: 15.336

5.  Effective top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker.

Authors:  Yi-Chen Chen; Serife Ayaz-Guner; Ying Peng; Nicole M Lane; Matthew Locher; Takushi Kohmoto; Lars Larsson; Richard L Moss; Ying Ge
Journal:  Anal Chem       Date:  2015-07-31       Impact factor: 6.986

6.  Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis.

Authors:  Chad R Weisbrod; Nathan K Kaiser; John E P Syka; Lee Early; Christopher Mullen; Jean-Jacques Dunyach; A Michelle English; Lissa C Anderson; Greg T Blakney; Jeffrey Shabanowitz; Christopher L Hendrickson; Alan G Marshall; Donald F Hunt
Journal:  J Am Soc Mass Spectrom       Date:  2017-07-18       Impact factor: 3.109

Review 7.  Identification and Quantification of Proteoforms by Mass Spectrometry.

Authors:  Leah V Schaffer; Robert J Millikin; Rachel M Miller; Lissa C Anderson; Ryan T Fellers; Ying Ge; Neil L Kelleher; Richard D LeDuc; Xiaowen Liu; Samuel H Payne; Liangliang Sun; Paul M Thomas; Trisha Tucholski; Zhe Wang; Si Wu; Zhijie Wu; Dahang Yu; Michael R Shortreed; Lloyd M Smith
Journal:  Proteomics       Date:  2019-05       Impact factor: 3.984

8.  Rapid Characterization of Insulin Modifications and Sequence Variations by Proteinase K Digestion and UHPLC-ESI-MS.

Authors:  Rong-Sheng Yang; Weijuan Tang; Huaming Sheng; Fanyu Meng
Journal:  J Am Soc Mass Spectrom       Date:  2018-01-29       Impact factor: 3.109

Review 9.  Ion Activation Methods for Peptides and Proteins.

Authors:  Jennifer S Brodbelt
Journal:  Anal Chem       Date:  2015-12-11       Impact factor: 6.986

Review 10.  Novel Strategies to Address the Challenges in Top-Down Proteomics.

Authors:  Jake A Melby; David S Roberts; Eli J Larson; Kyle A Brown; Elizabeth F Bayne; Song Jin; Ying Ge
Journal:  J Am Soc Mass Spectrom       Date:  2021-05-13       Impact factor: 3.109
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.