Literature DB >> 17901871

Decoding protein modifications using top-down mass spectrometry.

Nertila Siuti1, Neil L Kelleher.   

Abstract

Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present in vivo by measuring them intact, rather than measuring peptides produced from them by proteolysis. The top-down technology is beginning to capture the interest of biologists and mass spectrometrists alike, with a main goal of deciphering interaction networks operative in cellular pathways. Here we outline recent approaches and applications of top-down mass spectrometry as well as an outlook for its future.

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Year:  2007        PMID： 17901871      PMCID： PMC2365886          DOI： 10.1038/nmeth1097

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  45 in total

1.  Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS).

Authors:  K F Medzihradszky; X Zhang; R J Chalkley; S Guan; M A McFarland; M J Chalmers; A G Marshall; R L Diaz; C D Allis; A L Burlingame
Journal:  Mol Cell Proteomics       Date:  2004-06-15       Impact factor: 5.911

Review 2.  Top-down proteomics.

Authors:  Neil L Kelleher
Journal:  Anal Chem       Date:  2004-06-01       Impact factor: 6.986

3.  The Orbitrap: a new mass spectrometer.

Authors:  Qizhi Hu; Robert J Noll; Hongyan Li; Alexander Makarov; Mark Hardman; R Graham Cooks
Journal:  J Mass Spectrom       Date:  2005-04       Impact factor: 1.982

Review 4.  Top-down mass spectrometry of integral membrane proteins.

Authors:  Julian Whitelegge; Frederic Halgand; Puneet Souda; Vlad Zabrouskov
Journal:  Expert Rev Proteomics       Date:  2006-12       Impact factor: 3.940

5.  Extending top-down mass spectrometry to proteins with masses greater than 200 kilodaltons.

Authors:  Xuemei Han; Mi Jin; Kathrin Breuker; Fred W McLafferty
Journal:  Science       Date:  2006-10-06       Impact factor: 47.728

6.  Pervasive combinatorial modification of histone H3 in human cells.

Authors:  Benjamin A Garcia; James J Pesavento; Craig A Mizzen; Neil L Kelleher
Journal:  Nat Methods       Date:  2007-05-21       Impact factor: 28.547

7.  Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.

Authors:  Sean D Taverna; Beatrix M Ueberheide; Yifan Liu; Alan J Tackett; Robert L Diaz; Jeffrey Shabanowitz; Brian T Chait; Donald F Hunt; C David Allis
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-06       Impact factor: 11.205

8.  Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures.

Authors:  Jeffrey R Johnson; Fanyu Meng; Andrew J Forbes; Benjamin J Cargile; Neil L Kelleher
Journal:  Electrophoresis       Date:  2002-09       Impact factor: 3.535

9.  Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Authors:  An Chi; Curtis Huttenhower; Lewis Y Geer; Joshua J Coon; John E P Syka; Dina L Bai; Jeffrey Shabanowitz; Daniel J Burke; Olga G Troyanskaya; Donald F Hunt
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-07       Impact factor: 11.205

10.  Whole protein dissociation in a quadrupole ion trap: identification of an a priori unknown modified protein.

Authors:  Ravi Amunugama; Jason M Hogan; Kelly A Newton; Scott A McLuckey
Journal:  Anal Chem       Date:  2004-02-01       Impact factor: 6.986
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  185 in total

1.  Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T.

Authors:  Jiang Zhang; Han Zhang; Serife Ayaz-Guner; Yi-Chen Chen; Xintong Dong; Qingge Xu; Ying Ge
Journal:  Biochemistry       Date:  2011-06-15       Impact factor: 3.162

2.  Operating on chromatin, a colorful language where context matters.

Authors:  Kathryn E Gardner; C David Allis; Brian D Strahl
Journal:  J Mol Biol       Date:  2011-01-25       Impact factor: 5.469

3.  Protein identification using top-down.

Authors:  Xiaowen Liu; Yakov Sirotkin; Yufeng Shen; Gordon Anderson; Yihsuan S Tsai; Ying S Ting; David R Goodlett; Richard D Smith; Vineet Bafna; Pavel A Pevzner
Journal:  Mol Cell Proteomics       Date:  2011-10-25       Impact factor: 5.911

4.  Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation.

Authors:  David J Clarke; Euan Murray; Ted Hupp; C Logan Mackay; Pat R R Langridge-Smith
Journal:  J Am Soc Mass Spectrom       Date:  2011-05-11       Impact factor: 3.109

Review 5.  Chemical and biochemical approaches in the study of histone methylation and demethylation.

Authors:  Keqin Kathy Li; Cheng Luo; Dongxia Wang; Hualiang Jiang; Y George Zheng
Journal:  Med Res Rev       Date:  2012-07       Impact factor: 12.944

6.  Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach.

Authors:  Xiaowen Liu; Yuval Inbar; Pieter C Dorrestein; Colin Wynne; Nathan Edwards; Puneet Souda; Julian P Whitelegge; Vineet Bafna; Pavel A Pevzner
Journal:  Mol Cell Proteomics       Date:  2010-09-20       Impact factor: 5.911

Review 7.  The grand challenge to decipher the cancer proteome.

Authors:  Samir Hanash; Ayumu Taguchi
Journal:  Nat Rev Cancer       Date:  2010-09       Impact factor: 60.716

Review 8.  Using proteomics to study sexual reproduction in angiosperms.

Authors:  Ján A Miernyk; Anna Preťová; Adela Olmedilla; Katarína Klubicová; Bohuš Obert; Martin Hajduch
Journal:  Sex Plant Reprod       Date:  2010-09-10

Review 9.  Global and site-specific analysis of protein glycosylation in complex biological systems with Mass Spectrometry.

Authors:  Haopeng Xiao; Fangxu Sun; Suttipong Suttapitugsakul; Ronghu Wu
Journal:  Mass Spectrom Rev       Date:  2019-01-03       Impact factor: 10.946

Review 10.  Identification and Quantification of Proteoforms by Mass Spectrometry.

Authors:  Leah V Schaffer; Robert J Millikin; Rachel M Miller; Lissa C Anderson; Ryan T Fellers; Ying Ge; Neil L Kelleher; Richard D LeDuc; Xiaowen Liu; Samuel H Payne; Liangliang Sun; Paul M Thomas; Trisha Tucholski; Zhe Wang; Si Wu; Zhijie Wu; Dahang Yu; Michael R Shortreed; Lloyd M Smith
Journal:  Proteomics       Date:  2019-05       Impact factor: 3.984
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