R Menezes-Reis1, C E G Salmon2, C S Carvalho3, G P Bonugli3, C B Chung4, M H Nogueira-Barbosa3. 1. From the Division of Radiology (R.M.-R., G.P.B., C.S.C., M.H.N.-B.), Ribeirão Preto Medical School rafaelmenezesreis@gmail.com. 2. Department of Physics (C.E.G.S.), Ribeirão Preto Philosophy and Sciences School, University of São Paulo, São Paulo, Brazil. 3. From the Division of Radiology (R.M.-R., G.P.B., C.S.C., M.H.N.-B.), Ribeirão Preto Medical School. 4. Department of Radiology (C.B.C.), VA San Diego Healthcare System, San Diego, California.
Abstract
BACKGROUND AND PURPOSE: Intervertebral disk biochemical composition could be accessed in vivo by T1ρ and T2 relaxometry. We found no studies in the literature comparing different segmentation methods for data extraction using these techniques. Our aim was to compare different manual segmentation methods used to extract T1ρ and T2 relaxation times of intervertebral disks from MR imaging. Seven different methods of partial-disk segmentation techniques were compared with whole-disk segmentation as the reference standard. MATERIALS AND METHODS: Sagittal T1ρ and T2 maps were generated by using a 1.5T MR imaging scanner in 57 asymptomatic volunteers 20-40 years of age. Two hundred eighty-five lumbar disks were separated into 2 groups: nondegenerated disk (Pfirrmann I and II) and degenerated disk (Pfirrmann III and IV). In whole-disk segmentation, the disk was segmented in its entirety on all sections. Partial-disk segmentation methods included segmentation of the disk into 6, 5, 4, 3, and 1 sagittal sections. Circular ROIs positioned in the nucleus pulposus and annulus fibrosus were also used to extract T1ρ and T2, and data were compared with whole-disk segmentation RESULTS: In the nondegenerated group, segmentation of ≥5 sagittal sections showed no statistical difference with whole-disk segmentation. All the remaining partial-disk segmentation methods and circular ROIs showed different results from whole-disk segmentation (P < .001). In the degenerated disk group, all methods were statistically similar to whole-disk segmentation. All partial-segmentation methods, including circular ROIs, showed strong linear correlation with whole-disk segmentation in both the degenerated and nondegenerated disk groups. CONCLUSIONS: Manual segmentation showed strong reproducibility for T1ρ and T2 and strong linear correlation between partial- and whole-disk segmentation. Absolute T1ρ and T2 values extracted from different segmentation techniques were statistically different in disks with Pfirrmann grades I and II.
BACKGROUND AND PURPOSE: Intervertebral disk biochemical composition could be accessed in vivo by T1ρ and T2 relaxometry. We found no studies in the literature comparing different segmentation methods for data extraction using these techniques. Our aim was to compare different manual segmentation methods used to extract T1ρ and T2 relaxation times of intervertebral disks from MR imaging. Seven different methods of partial-disk segmentation techniques were compared with whole-disk segmentation as the reference standard. MATERIALS AND METHODS: Sagittal T1ρ and T2 maps were generated by using a 1.5T MR imaging scanner in 57 asymptomatic volunteers 20-40 years of age. Two hundred eighty-five lumbar disks were separated into 2 groups: nondegenerated disk (Pfirrmann I and II) and degenerated disk (Pfirrmann III and IV). In whole-disk segmentation, the disk was segmented in its entirety on all sections. Partial-disk segmentation methods included segmentation of the disk into 6, 5, 4, 3, and 1 sagittal sections. Circular ROIs positioned in the nucleus pulposus and annulus fibrosus were also used to extract T1ρ and T2, and data were compared with whole-disk segmentation RESULTS: In the nondegenerated group, segmentation of ≥5 sagittal sections showed no statistical difference with whole-disk segmentation. All the remaining partial-disk segmentation methods and circular ROIs showed different results from whole-disk segmentation (P < .001). In the degenerated disk group, all methods were statistically similar to whole-disk segmentation. All partial-segmentation methods, including circular ROIs, showed strong linear correlation with whole-disk segmentation in both the degenerated and nondegenerated disk groups. CONCLUSIONS: Manual segmentation showed strong reproducibility for T1ρ and T2 and strong linear correlation between partial- and whole-disk segmentation. Absolute T1ρ and T2 values extracted from different segmentation techniques were statistically different in disks with Pfirrmann grades I and II.
Authors: Jeffrey C Lotz; Victor Haughton; Scott D Boden; Howard S An; James D Kang; Koichi Masuda; Anthony Freemont; Sigurd Berven; Dilip K Sengupta; Lawrence Tanenbaum; Philip Maurer; Arun Ranganathan; Abass Alavi; Nicholas L Marinelli Journal: Radiology Date: 2012-07 Impact factor: 11.105
Authors: Merel Wassenaar; Rogier M van Rijn; Maurits W van Tulder; Arianne P Verhagen; Danielle A W M van der Windt; Bart W Koes; Michiel R de Boer; Abida Z Ginai; Raymond W J G Ostelo Journal: Eur Spine J Date: 2011-09-16 Impact factor: 3.134
Authors: Yi-Xiang J Wang; Feng Zhao; James F Griffith; Greta S P Mok; Jason C S Leung; Anil T Ahuja; Jing Yuan Journal: Eur Radiol Date: 2012-08-04 Impact factor: 5.315
Authors: Arijitt Borthakur; Philip M Maurer; Matthew Fenty; Chenyang Wang; Rachelle Berger; Jonathon Yoder; Richard A Balderston; Dawn M Elliott Journal: Spine (Phila Pa 1976) Date: 2011-12-01 Impact factor: 3.468
Authors: Rafael Menezes-Reis; Carlos E Garrido Salmon; Gustavo P Bonugli; Debora Mazoroski; Mauricio H Tamashiro; Leonor G Savarese; Marcello Henrique Nogueira-Barbosa Journal: Quant Imaging Med Surg Date: 2016-08
Authors: Yeon Hwa Yoo; Choon-Sik Yoon; Na Lae Eun; Moon-Jung Hwang; Hanna Yoo; Robert D Peters; Tae-Sub Chung; Young Han Lee; Jin-Suck Suh; Sungjun Kim Journal: Korean J Radiol Date: 2016-10-31 Impact factor: 3.500
Authors: Rafael Menezes-Reis; Carlos E Garrido Salmon; Gustavo P Bonugli; Debora Mazoroski; Leonor G Savarese; Carlos Fernando P S Herrero; Helton L A Defino; Marcello Henrique Nogueira-Barbosa Journal: Quant Imaging Med Surg Date: 2021-06
Authors: Cornelis P L Paul; Theodoor H Smit; Magda de Graaf; Roderick M Holewijn; Arno Bisschop; Peter M van de Ven; Margriet G Mullender; Marco N Helder; Gustav J Strijkers Journal: PLoS One Date: 2018-01-30 Impact factor: 3.240