Wen Hao1, Bin Zhao, Guangbin Wang, Cuiyan Wang, Hui Liu. 1. Department of MR Imaging, Shandong Medical Imaging Research Institute, Shandong University, 324 Jingwu Road, Jinan, Shandong, 250021, China.
Abstract
OBJECTIVES: To evaluate the influence of scan duration on pharmacokinetic parameters and their performance in differentiating benign from malignant breast lesions. METHODS: Dynamic breast imaging was performed on a 3.0-T MR system using a prototype CAIPIRINHA-Dixon-TWISTVIBE (CDT-VIBE) sequence with a temporal resolution of 11.9 s. Enrolled in the study were 53 women with 55 lesions (26 benign and 29 malignant). Pharmacokinetic parameters (Ktrans, ve , kep and iAUC) were calculated for various scan durations from 1 to 7 min after injection of contrast medium using the Tofts model. RESULTS: Ktrans, kep and ve calculated from the 1-min dataset were significantly different from those calculated from the other datasets. In benign lesions, Ktrans, kep and ve were significantly different only between 1 min and 2 min (corrected P > 0.05), but in malignant lesions there were significant differences for any of the comparisons up to 6 min vs. 7 min (corrected P > 0.05). There were no significant differences in AUCs for any of the parameters (P > 0.05). CONCLUSIONS: In breast dynamic contrast-enhanced MRI the scan duration has a significant impact on pharmacokinetic parameters, but the diagnostic ability may not be significantly affected. A scan duration of 5 min after injection of contrast medium may be sufficient for calculation of Tofts model pharmacokinetic parameters. KEY POINTS: • Scan duration of DCE-MRI breast imaging has a significant impact on pharmacokinetic parameters • A scan duration of less than 2 min results in spurious parameter estimates • The initial 2 min are important for both benign and malignant lesions • In malignant lesions the impact extends to 4 - 6 min • The differentiation ability of parameters may not be affected by scan duration.
OBJECTIVES: To evaluate the influence of scan duration on pharmacokinetic parameters and their performance in differentiating benign from malignant breast lesions. METHODS: Dynamic breast imaging was performed on a 3.0-T MR system using a prototype CAIPIRINHA-Dixon-TWISTVIBE (CDT-VIBE) sequence with a temporal resolution of 11.9 s. Enrolled in the study were 53 women with 55 lesions (26 benign and 29 malignant). Pharmacokinetic parameters (Ktrans, ve , kep and iAUC) were calculated for various scan durations from 1 to 7 min after injection of contrast medium using the Tofts model. RESULTS: Ktrans, kep and ve calculated from the 1-min dataset were significantly different from those calculated from the other datasets. In benign lesions, Ktrans, kep and ve were significantly different only between 1 min and 2 min (corrected P > 0.05), but in malignant lesions there were significant differences for any of the comparisons up to 6 min vs. 7 min (corrected P > 0.05). There were no significant differences in AUCs for any of the parameters (P > 0.05). CONCLUSIONS: In breast dynamic contrast-enhanced MRI the scan duration has a significant impact on pharmacokinetic parameters, but the diagnostic ability may not be significantly affected. A scan duration of 5 min after injection of contrast medium may be sufficient for calculation of Tofts model pharmacokinetic parameters. KEY POINTS: • Scan duration of DCE-MRI breast imaging has a significant impact on pharmacokinetic parameters • A scan duration of less than 2 min results in spurious parameter estimates • The initial 2 min are important for both benign and malignant lesions • In malignant lesions the impact extends to 4 - 6 min • The differentiation ability of parameters may not be affected by scan duration.
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