PURPOSE: To assess the effects of reduced scan time in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of breast for the evaluation of pharmacokinetic parameters (K(trans) , ve , and kep ). MATERIALS AND METHODS: High temporal resolution DCE-MRI was performed for calculation of pharmacokinetic parameters (K(trans) , ve , and kep ) at different timepoints using an in-house developed computation scheme adopting the standard model (SM). RESULTS: The receiver operating characteristic (ROC) curve analysis revealed an area under the ROC curve (AUC) of 0.994 for K(trans) at 90 seconds and 0.987 for K(trans) at 60 seconds with a significant decrease in the AUC for K(trans) at 30 seconds (0.669). While ve showed a consistently higher AUC (>0.9) at timepoints ≥40 seconds, the AUC for kep showed a consistent decline with reduced acquisition times. CONCLUSION: Reducing the acquisition time for the K(trans) and ve measurement up to 60 seconds yields reasonable accuracy for both and can be incorporated in the routine DCE-MRI protocol for evaluation of enhancing breast lesions.
RCT Entities:
PURPOSE: To assess the effects of reduced scan time in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of breast for the evaluation of pharmacokinetic parameters (K(trans) , ve , and kep ). MATERIALS AND METHODS: High temporal resolution DCE-MRI was performed for calculation of pharmacokinetic parameters (K(trans) , ve , and kep ) at different timepoints using an in-house developed computation scheme adopting the standard model (SM). RESULTS: The receiver operating characteristic (ROC) curve analysis revealed an area under the ROC curve (AUC) of 0.994 for K(trans) at 90 seconds and 0.987 for K(trans) at 60 seconds with a significant decrease in the AUC for K(trans) at 30 seconds (0.669). While ve showed a consistently higher AUC (>0.9) at timepoints ≥40 seconds, the AUC for kep showed a consistent decline with reduced acquisition times. CONCLUSION: Reducing the acquisition time for the K(trans) and ve measurement up to 60 seconds yields reasonable accuracy for both and can be incorporated in the routine DCE-MRI protocol for evaluation of enhancing breast lesions.
Authors: Wei Huang; Yiyi Chen; Andriy Fedorov; Xia Li; Guido H Jajamovich; Dariya I Malyarenko; Madhava P Aryal; Peter S LaViolette; Matthew J Oborski; Finbarr O'Sullivan; Richard G Abramson; Kourosh Jafari-Khouzani; Aneela Afzal; Alina Tudorica; Brendan Moloney; Sandeep N Gupta; Cecilia Besa; Jayashree Kalpathy-Cramer; James M Mountz; Charles M Laymon; Mark Muzi; Kathleen Schmainda; Yue Cao; Thomas L Chenevert; Bachir Taouli; Thomas E Yankeelov; Fiona Fennessy; Xin Li Journal: Tomography Date: 2016-03