Literature DB >> 2528686

PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle.

S P Bjørn1, A Soltyk, J D Beggs, J D Friesen.   

Abstract

The PRP4 (RNA4) gene product is involved in nuclear mRNA processing in yeast cells; we have previously cloned the gene by complementation of a temperature-sensitive mutation. Sequence and transcript analyses of the cloned gene predicted the gene product to be a 52-kilodalton protein, which was confirmed with antibodies raised against the PRP4 gene product. These antibodies inhibited precursor mRNA splicing in vitro, demonstrating a direct role of PRP4 in splicing. Immunoprecipitations with the antibodies indicated that the PRP4 protein is associated with the U4/U6 small nuclear ribonucleoprotein particle.

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Year:  1989        PMID： 2528686      PMCID： PMC362430          DOI： 10.1128/mcb.9.9.3698-3709.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  61 in total

1.  A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNA.

Authors:  V Gerke; J A Steitz
Journal:  Cell       Date:  1986-12-26       Impact factor: 41.582

Review 2.  Splicing of messenger RNA precursors.

Authors:  R A Padgett; P J Grabowski; M M Konarska; S Seiler; P A Sharp
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

3.  A compensatory base change in U1 snRNA suppresses a 5' splice site mutation.

Authors:  Y Zhuang; A M Weiner
Journal:  Cell       Date:  1986-09-12       Impact factor: 41.582

4.  Specific small nuclear RNAs are associated with yeast spliceosomes.

Authors:  C W Pikielny; M Rosbash
Journal:  Cell       Date:  1986-06-20       Impact factor: 41.582

5.  The yeast RNA gene products are essential for mRNA splicing in vitro.

Authors:  A J Lustig; R J Lin; J Abelson
Journal:  Cell       Date:  1986-12-26       Impact factor: 41.582

6.  Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae.

Authors:  A Percival-Smith; J Segall
Journal:  Mol Cell Biol       Date:  1986-07       Impact factor: 4.272

7.  Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity.

Authors:  N Riedel; J A Wise; H Swerdlow; A Mak; C Guthrie
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

8.  Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing.

Authors:  L A Fouser; J D Friesen
Journal:  Cell       Date:  1986-04-11       Impact factor: 41.582

9.  A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein.

Authors:  J Tazi; C Alibert; J Temsamani; I Reveillaud; G Cathala; C Brunel; P Jeanteur
Journal:  Cell       Date:  1986-12-05       Impact factor: 41.582

10.  Identification and nuclear localization of yeast pre-messenger RNA processing components: RNA2 and RNA3 proteins.

Authors:  R L Last; J L Woolford
Journal:  J Cell Biol       Date:  1986-12       Impact factor: 10.539
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  49 in total

1.  Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k.

Authors:  A A Lukowiak; S Granneman; S A Mattox; W A Speckmann; K Jones; H Pluk; W J Venrooij; R M Terns; M P Terns
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

2.  Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins.

Authors:  Stephanie Nottrott; Henning Urlaub; Reinhard Lührmann
Journal:  EMBO J       Date:  2002-10-15       Impact factor: 11.598

3.  Reconstitution of functional mammalian U4 small nuclear ribonucleoprotein: Sm protein binding is not essential for splicing in vitro.

Authors:  C Wersig; A Bindereif
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

4.  Genetic studies of the PRP11 gene of Saccharomyces cerevisiae.

Authors:  K Schappert; J D Friesen
Journal:  Mol Gen Genet       Date:  1991-04

5.  WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation.

Authors:  Fabio Pittella Silva; Ryuji Hamamoto; Yusuke Nakamura; Yoichi Furukawa
Journal:  Neoplasia       Date:  2005-04       Impact factor: 5.715

6.  U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction.

Authors:  S L Yean; R J Lin
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

7.  Conserved domains of human U4 snRNA required for snRNP and spliceosome assembly.

Authors:  C Wersig; A Bindereif
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

8.  The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.

Authors:  A L Pinto; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

9.  PRP5: a helicase-like protein required for mRNA splicing in yeast.

Authors:  G Dalbadie-McFarland; J Abelson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

10.  Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.

Authors:  J Hu; Y Xu; K Schappert; T Harrington; A Wang; R Braga; J Mogridge; J D Friesen
Journal:  Nucleic Acids Res       Date:  1994-05-11       Impact factor: 16.971
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