Literature DB >> 25280965

Framing expectations in early HIV cure research.

Karine Dubé1, Gail E Henderson2, David M Margolis3.   

Abstract

Language used to describe clinical research represents a powerful opportunity to educate volunteers. In the case of HIV cure research there is an emerging need to manage expectations by using the term 'experiment'. Cure experiments are proof-of-concept studies designed to evaluate novel paradigms to reduce persistent HIV-1 reservoirs, without any expectation of medical benefit.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV cure research; expectations; experiments; trials

Mesh：

Year:  2014        PMID： 25280965      PMCID： PMC4201845          DOI： 10.1016/j.tim.2014.08.003

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  10 in total

1.  Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy.

Authors:  J M Prins; S Jurriaans; R M van Praag; H Blaak; R van Rij; P T Schellekens; I J ten Berge; S L Yong; C H Fox; M T Roos; F de Wolf; J Goudsmit; H Schuitemaker; J M Lange
Journal:  AIDS       Date:  1999-12-03       Impact factor: 4.177

2.  HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.

Authors:  Nancy M Archin; Rosalie Bateson; Manoj K Tripathy; Amanda M Crooks; Kuo-Hsiung Yang; Noelle P Dahl; Mary F Kearney; Elizabeth M Anderson; John M Coffin; Matthew C Strain; Douglas D Richman; Kevin R Robertson; Angela D Kashuba; Ronald J Bosch; Daria J Hazuda; Joann D Kuruc; Joseph J Eron; David M Margolis
Journal:  J Infect Dis       Date:  2014-03-11       Impact factor: 5.226

3.  The therapeutic misconception: informed consent in psychiatric research.

Authors:  P S Appelbaum; L H Roth; C Lidz
Journal:  Int J Law Psychiatry       Date:  1982

4.  Depletion of latent HIV-1 infection in vivo: a proof-of-concept study.

Authors:  Ginger Lehrman; Ian B Hogue; Sarah Palmer; Cheryl Jennings; Celsa A Spina; Ann Wiegand; Alan L Landay; Robert W Coombs; Douglas D Richman; John W Mellors; John M Coffin; Ronald J Bosch; David M Margolis
Journal:  Lancet       Date:  2005 Aug 13-19       Impact factor: 79.321

5.  Absence of detectable HIV-1 viremia after treatment cessation in an infant.

Authors:  Deborah Persaud; Hannah Gay; Carrie Ziemniak; Ya Hui Chen; Michael Piatak; Tae-Wook Chun; Matthew Strain; Douglas Richman; Katherine Luzuriaga
Journal:  N Engl J Med       Date:  2013-10-23       Impact factor: 91.245

6.  Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.

Authors:  Kristina Allers; Gero Hütter; Jörg Hofmann; Christoph Loddenkemper; Kathrin Rieger; Eckhard Thiel; Thomas Schneider
Journal:  Blood       Date:  2010-12-08       Impact factor: 22.113

7.  Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.

Authors:  Nancie M Archin; Amy Espeseth; Daniel Parker; Manzoor Cheema; Daria Hazuda; David M Margolis
Journal:  AIDS Res Hum Retroviruses       Date:  2009-02       Impact factor: 2.205

8.  CD4+ count-guided interruption of antiretroviral treatment.

Authors:  W M El-Sadr; J D Lundgren; J D Neaton; F Gordin; D Abrams; R C Arduino; A Babiker; W Burman; N Clumeck; C J Cohen; D Cohn; D Cooper; J Darbyshire; S Emery; G Fätkenheuer; B Gazzard; B Grund; J Hoy; K Klingman; M Losso; N Markowitz; J Neuhaus; A Phillips; C Rappoport
Journal:  N Engl J Med       Date:  2006-11-30       Impact factor: 91.245

9.  Clinical trials and medical care: defining the therapeutic misconception.

Authors:  Gail E Henderson; Larry R Churchill; Arlene M Davis; Michele M Easter; Christine Grady; Steven Joffe; Nancy Kass; Nancy M P King; Charles W Lidz; Franklin G Miller; Daniel K Nelson; Jeffrey Peppercorn; Barbra Bluestone Rothschild; Pamela Sankar; Benjamin S Wilfond; Catherine R Zimmer
Journal:  PLoS Med       Date:  2007-11-27       Impact factor: 11.069

Review 10.  The time is now: moving toward virus-specific T cells after allogeneic hematopoietic stem cell transplantation as the standard of care.

Authors:  Francesco Saglio; Patrick J Hanley; Catherine M Bollard
Journal:  Cytotherapy       Date:  2014-02       Impact factor: 5.414
  10 in total
  36 in total

1.  Perceptions of HIV Virologic Control Strategies Among Younger and Older Age Groups of People Living with HIV in the United States: A Cross-Sectional Survey.

Authors:  Parya Saberi; Shadi Eskaf; John Sauceda; David Evans; Karine Dubé
Journal:  AIDS Res Hum Retroviruses       Date:  2020-05-27       Impact factor: 2.205

2.  The ethics of HIV "cure" research: what can we learn from consent forms?

Authors:  Gail E Henderson
Journal:  AIDS Res Hum Retroviruses       Date:  2015-01       Impact factor: 2.205

3.  The Dose Response: Perceptions of People Living with HIV in the United States on Alternatives to Oral Daily Antiretroviral Therapy.

Authors:  Karine Dubé; Shadi Eskaf; David Evans; John Sauceda; Parya Saberi; Brandon Brown; Dawn Averitt; Krista Martel; Maria Meija; Danielle Campbell; Liz Barr; John Kanazawa; Kelly Perry; Hursch Patel; Stuart Luter; Tonia Poteat; Judith D Auerbach; David A Wohl
Journal:  AIDS Res Hum Retroviruses       Date:  2019-12-04       Impact factor: 2.205

Review 4.  Traditional, complementary, and alternative medical cures for HIV: rationale and implications for HIV cure research.

Authors:  Xin Pan; Alice Zhang; Gail E Henderson; Stuart Rennie; Chuncheng Liu; Weiping Cai; Feng Wu; Joseph D Tucker
Journal:  Glob Public Health       Date:  2017-12-13

5.  An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization.

Authors:  T Aaron Bedell; Graham A B Hone; Justin Du Bois; Erik J Sorensen
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

6.  Acceptability of Cell and Gene Therapy for Curing HIV Infection Among People Living with HIV in the Northwestern United States: A Qualitative Study.

Authors:  Karine Dubé; Jane Simoni; Michael Louella; Laurie Sylla; Zahra H Mohamed; Hursch Patel; Stuart Luter; Ann C Collier
Journal:  AIDS Res Hum Retroviruses       Date:  2019-05-21       Impact factor: 2.205

7.  Understanding Willingness to Participate in HIV Biomedical Research: A Mixed Methods Investigation.

Authors:  Ji-Young Lee; Sara M St George; Torsten B Neilands; Allan Rodriguez; Daniel J Feaster; Adam W Carrico
Journal:  AIDS Behav       Date:  2021-06-15

8.  Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research.

Authors:  Cynthia I Grossman; Anna Laura Ross; Judith D Auerbach; Jintanat Ananworanich; Karine Dubé; Joseph D Tucker; Veronica Noseda; Cristina Possas; Dianne M Rausch
Journal:  Trends Microbiol       Date:  2015-11-28       Impact factor: 17.079

9.  If We Build It, Will They Come? Perceptions of HIV Cure-Related Research by People Living with HIV in Four U.S. Cities: A Qualitative Focus Group Study.

Authors:  Laurie Sylla; David Evans; Jeff Taylor; Adam Gilbertson; David Palm; Judith D Auerbach; Karine Dubé
Journal:  AIDS Res Hum Retroviruses       Date:  2018-01       Impact factor: 2.205

10.  Perceptions of Equipoise, Risk-Benefit Ratios, and "Otherwise Healthy Volunteers" in the Context of Early-Phase HIV Cure Research in the United States: A Qualitative Inquiry.

Authors:  Karine Dubé; Lynda Dee; David Evans; Laurie Sylla; Jeff Taylor; Brandon Brown; Veronica Miller; Amy Corneli; Asheley Skinner; Sandra B Greene; Joseph D Tucker; Stuart Rennie
Journal:  J Empir Res Hum Res Ethics       Date:  2017-10-06       Impact factor: 1.742
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