Literature DB >> 26120216

An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization.

T Aaron Bedell1, Graham A B Hone1, Justin Du Bois2, Erik J Sorensen1.   

Abstract

A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.

Entities:  

Keywords:  Amination; C-H functionalization; CCR-5; HIV/AIDS; Maraviroc

Year:  2015        PMID： 26120216      PMCID： PMC4477708          DOI： 10.1016/j.tetlet.2015.01.074

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


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