Literature DB >> 26642901

Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research.

Cynthia I Grossman1, Anna Laura Ross2, Judith D Auerbach3, Jintanat Ananworanich4, Karine Dubé5, Joseph D Tucker6, Veronica Noseda7, Cristina Possas8, Dianne M Rausch9.   

Abstract

The quest for a cure for HIV remains a timely and key challenge for the HIV research community. Despite significant scientific advances, current HIV therapy regimens do not completely eliminate the negative impact of HIV on the immune system; and the economic impact of treating all people infected with HIV globally, for the duration of their lifetimes, presents significant challenges. This article discusses, from a multidisciplinary approach, critical social, behavioral, ethical, and economic issues permeating the HIV-cure research agenda. As part of a search for an HIV cure, both the perspective of patients/participants and clinical researchers should be taken into account. In addition, continued efforts should be made to involve and educate the broader community. Published by Elsevier Ltd.

Entities:  

Keywords:  HIV cure; cost-effectiveness; ethics; multidisciplinary; public understanding of science

Mesh:

Year:  2015        PMID: 26642901      PMCID: PMC4698010          DOI: 10.1016/j.tim.2015.10.011

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN: 0966-842X            Impact factor:   17.079


  33 in total

1.  Value of information methods for planning and analyzing clinical studies optimize decision making and research planning.

Authors:  Andrew R Willan; Ron Goeree; Kathy Boutis
Journal:  J Clin Epidemiol       Date:  2012-05-18       Impact factor: 6.437

2.  Therapeutic misconception in early phase gene transfer trials.

Authors:  Gail E Henderson; Michele M Easter; Catherine Zimmer; Nancy M P King; Arlene M Davis; Barbra Bluestone Rothschild; Larry R Churchill; Benjamin S Wilfond; Daniel K Nelson
Journal:  Soc Sci Med       Date:  2005-07-05       Impact factor: 4.634

Review 3.  Towards an HIV cure: a global scientific strategy.

Authors:  Steven G Deeks; Brigitte Autran; Ben Berkhout; Monsef Benkirane; Scott Cairns; Nicolas Chomont; Tae-Wook Chun; Melissa Churchill; Michele Di Mascio; Christine Katlama; Alain Lafeuillade; Alan Landay; Michael Lederman; Sharon R Lewin; Frank Maldarelli; David Margolis; Martin Markowitz; Javier Martinez-Picado; James I Mullins; John Mellors; Santiago Moreno; Una O'Doherty; Sarah Palmer; Marie-Capucine Penicaud; Matija Peterlin; Guido Poli; Jean-Pierre Routy; Christine Rouzioux; Guido Silvestri; Mario Stevenson; Amalio Telenti; Carine Van Lint; Eric Verdin; Ann Woolfrey; John Zaia; Françoise Barré-Sinoussi
Journal:  Nat Rev Immunol       Date:  2012-07-20       Impact factor: 53.106

4.  Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells.

Authors:  Michael M Lederman; Leonard Calabrese; Nicholas T Funderburg; Brian Clagett; Kathy Medvik; Hector Bonilla; Barbara Gripshover; Robert A Salata; Alan Taege; Michelle Lisgaris; Grace A McComsey; Elizabeth Kirchner; Jane Baum; Carey Shive; Robert Asaad; Robert C Kalayjian; Scott F Sieg; Benigno Rodriguez
Journal:  J Infect Dis       Date:  2011-10-15       Impact factor: 5.226

5.  Projected life expectancy of people with HIV according to timing of diagnosis.

Authors:  Fumiyo Nakagawa; Rebecca K Lodwick; Colette J Smith; Ruth Smith; Valentina Cambiano; Jens D Lundgren; Valerie Delpech; Andrew N Phillips
Journal:  AIDS       Date:  2012-01-28       Impact factor: 4.177

6.  Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.

Authors:  Kristina Allers; Gero Hütter; Jörg Hofmann; Christoph Loddenkemper; Kathrin Rieger; Eckhard Thiel; Thomas Schneider
Journal:  Blood       Date:  2010-12-08       Impact factor: 22.113

7.  Accepting being poz: the incorporation of the HIV identity into the self.

Authors:  Lisa M Baumgartner; Keegan N David
Journal:  Qual Health Res       Date:  2009-12

8.  How do patients know?

Authors:  Rebecca Kukla
Journal:  Hastings Cent Rep       Date:  2007 Sep-Oct       Impact factor: 2.683

9.  Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease.

Authors:  Hernan Valdez; Elizabeth Connick; Kimberly Y Smith; Michael M Lederman; Ronald J Bosch; Ryung S Kim; Marty St Clair; Daniel R Kuritzkes; Harold Kessler; Lawrence Fox; Michelle Blanchard-Vargas; Alan Landay
Journal:  AIDS       Date:  2002-09-27       Impact factor: 4.177

10.  HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Authors:  Nicolas Chomont; Mohamed El-Far; Petronela Ancuta; Lydie Trautmann; Francesco A Procopio; Bader Yassine-Diab; Geneviève Boucher; Mohamed-Rachid Boulassel; Georges Ghattas; Jason M Brenchley; Timothy W Schacker; Brenna J Hill; Daniel C Douek; Jean-Pierre Routy; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Nat Med       Date:  2009-06-21       Impact factor: 53.440

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  35 in total

1.  Participant Perspectives in an HIV Cure-Related Trial Conducted Exclusively in Women in the United States: Results from AIDS Clinical Trials Group 5366.

Authors:  Karine Dubé; Lara Hosey; Kate Starr; Liz Barr; David Evans; Erin Hoffman; Danielle M Campbell; Jane Simoni; Jeremy Sugarman; John Sauceda; Brandon Brown; Karen L Diepstra; Catherine Godfrey; Daniel R Kuritzkes; David A Wohl; Rajesh Gandhi; Eileen Scully
Journal:  AIDS Res Hum Retroviruses       Date:  2020-04       Impact factor: 2.205

2.  "We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry.

Authors:  Karine Dubé; David Evans; Lynda Dee; Laurie Sylla; Jeff Taylor; Asheley Skinner; Bryan J Weiner; Sandra B Greene; Stuart Rennie; Joseph D Tucker
Journal:  AIDS Res Hum Retroviruses       Date:  2017-07-10       Impact factor: 2.205

3.  Perceptions of HIV Virologic Control Strategies Among Younger and Older Age Groups of People Living with HIV in the United States: A Cross-Sectional Survey.

Authors:  Parya Saberi; Shadi Eskaf; John Sauceda; David Evans; Karine Dubé
Journal:  AIDS Res Hum Retroviruses       Date:  2020-05-27       Impact factor: 2.205

4.  Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.

Authors:  Boris Julg; Lynda Dee; Jintanat Ananworanich; Dan H Barouch; Katharine Bar; Marina Caskey; Donn J Colby; Liza Dawson; Krista L Dong; Karine Dubé; Joseph Eron; John Frater; Rajesh T Gandhi; Romas Geleziunas; Philip Goulder; George J Hanna; Richard Jefferys; Rowena Johnston; Daniel Kuritzkes; Jonathan Z Li; Udom Likhitwonnawut; Jan van Lunzen; Javier Martinez-Picado; Veronica Miller; Luis J Montaner; Douglas F Nixon; David Palm; Giuseppe Pantaleo; Holly Peay; Deborah Persaud; Jessica Salzwedel; Karl Salzwedel; Timothy Schacker; Virginia Sheikh; Ole S Søgaard; Serena Spudich; Kathryn Stephenson; Jeremy Sugarman; Jeff Taylor; Pablo Tebas; Caroline T Tiemessen; Randall Tressler; Carol D Weiss; Lu Zheng; Merlin L Robb; Nelson L Michael; John W Mellors; Steven G Deeks; Bruce D Walker
Journal:  Lancet HIV       Date:  2019-03-15       Impact factor: 12.767

5.  Reasons People Living with HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options.

Authors:  Karine Dubé; Danielle M Campbell; Kelly E Perry; John T Kanazawa; Parya Saberi; John A Sauceda; Tonia Poteat; David Evans
Journal:  AIDS Res Hum Retroviruses       Date:  2020-09-14       Impact factor: 2.205

6.  The Dose Response: Perceptions of People Living with HIV in the United States on Alternatives to Oral Daily Antiretroviral Therapy.

Authors:  Karine Dubé; Shadi Eskaf; David Evans; John Sauceda; Parya Saberi; Brandon Brown; Dawn Averitt; Krista Martel; Maria Meija; Danielle Campbell; Liz Barr; John Kanazawa; Kelly Perry; Hursch Patel; Stuart Luter; Tonia Poteat; Judith D Auerbach; David A Wohl
Journal:  AIDS Res Hum Retroviruses       Date:  2019-12-04       Impact factor: 2.205

7.  Acceptability of Cell and Gene Therapy for Curing HIV Infection Among People Living with HIV in the Northwestern United States: A Qualitative Study.

Authors:  Karine Dubé; Jane Simoni; Michael Louella; Laurie Sylla; Zahra H Mohamed; Hursch Patel; Stuart Luter; Ann C Collier
Journal:  AIDS Res Hum Retroviruses       Date:  2019-05-21       Impact factor: 2.205

8.  What Would an HIV Cure Mean to You? Qualitative Analysis from a Crowdsourcing Contest in Guangzhou, China.

Authors:  Alice Zhang; Xin Pan; Feng Wu; Yang Zhao; Fengyu Hu; Linghua Li; Weiping Cai; Joseph D Tucker
Journal:  AIDS Res Hum Retroviruses       Date:  2017-10-12       Impact factor: 2.205

9.  If We Build It, Will They Come? Perceptions of HIV Cure-Related Research by People Living with HIV in Four U.S. Cities: A Qualitative Focus Group Study.

Authors:  Laurie Sylla; David Evans; Jeff Taylor; Adam Gilbertson; David Palm; Judith D Auerbach; Karine Dubé
Journal:  AIDS Res Hum Retroviruses       Date:  2018-01       Impact factor: 2.205

10.  Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection.

Authors:  Linda Oseso; Amalia S Magaret; Keith R Jerome; Julie Fox; Anna Wald
Journal:  Sex Transm Dis       Date:  2016-09       Impact factor: 2.830

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