Chen Chen1, Yinlong Jin1, Frederick W Unverzagt2, Yibin Cheng1, Ann M Hake3, Chaoke Liang1, Feng Ma1, Liqin Su1, Jingyi Liu1, Jianchao Bian4, Ping Li5, Sujuan Gao6. 1. Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing, China. 2. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States. 3. Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States; Eli Lilly and Company, Indianapolis, IN, United States. 4. Shandong Institute for Prevention and Treatment of Endemic Disease in China, Jinan, China. 5. Sichuan Provincial Center for Disease Control and Prevention in China, Chengdu, China. 6. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: sgao@iupui.edu.
Abstract
OBJECTIVE: A protective effect of selenium on lipid levels has been reported in populations with relatively low selenium status. However, recent studies found that high selenium exposure may lead to adverse cardiometabolic effects, particularly in selenium-replete populations. We examined the associations of selenium status with changes in lipid levels in a 7-year follow up of an elderly Chinese cohort including participants from selenium-deplete areas. METHODS: Study population consisted of 140 elderly Chinese aged 65 or older with nail selenium levels measured at baseline (2003-2005). Lipid concentrations were measured in fasting blood samples collected at baseline and the 7-year follow-up (2010-2012). Analysis of covariance (ANCOVA) models was used to determine the association between baseline selenium status and changes in lipid levels from baseline to follow-up adjusting for other covariates. RESULTS: Mean (±standard deviation) baseline selenium concentration was 0.41±0.2mg/kg. In prospective analysis, we found that individuals in the highest selenium quartile group showed 1.11 SD decrease on total-cholesterol (p<0.001), 0.41 SD increase on HDL-cholesterol (p<0.001) and 0.52 SD decrease on triglyceride after 7 years than those in the lowest selenium quartile group. The similar trends were seen with significant lipid changes in the 2nd and 3rd quartile groups. CONCLUSION: Selenium has modest beneficial effects on blood lipid levels in a population with relatively low selenium status. Our result suggests adequate dietary selenium intake as a potential prevention strategy for lowering lipid levels in selenium deplete populations.
OBJECTIVE: A protective effect of selenium on lipid levels has been reported in populations with relatively low selenium status. However, recent studies found that high selenium exposure may lead to adverse cardiometabolic effects, particularly in selenium-replete populations. We examined the associations of selenium status with changes in lipid levels in a 7-year follow up of an elderly Chinese cohort including participants from selenium-deplete areas. METHODS: Study population consisted of 140 elderly Chinese aged 65 or older with nail selenium levels measured at baseline (2003-2005). Lipid concentrations were measured in fasting blood samples collected at baseline and the 7-year follow-up (2010-2012). Analysis of covariance (ANCOVA) models was used to determine the association between baseline selenium status and changes in lipid levels from baseline to follow-up adjusting for other covariates. RESULTS: Mean (±standard deviation) baseline selenium concentration was 0.41±0.2mg/kg. In prospective analysis, we found that individuals in the highest selenium quartile group showed 1.11 SD decrease on total-cholesterol (p<0.001), 0.41 SD increase on HDL-cholesterol (p<0.001) and 0.52 SD decrease on triglyceride after 7 years than those in the lowest selenium quartile group. The similar trends were seen with significant lipid changes in the 2nd and 3rd quartile groups. CONCLUSION:Selenium has modest beneficial effects on blood lipid levels in a population with relatively low selenium status. Our result suggests adequate dietary selenium intake as a potential prevention strategy for lowering lipid levels in selenium deplete populations.
Authors: Nicole M Wolf; Kristin Mueller; Frank Hirche; Erika Most; Josef Pallauf; Andreas S Mueller Journal: Br J Nutr Date: 2010-03-30 Impact factor: 3.718
Authors: P Xun; N Hou; M Daviglus; K Liu; J S Morris; J M Shikany; S Sidney; D R Jacobs; K He Journal: J Intern Med Date: 2011-01-09 Impact factor: 8.989
Authors: Anna Mirończuk; Katarzyna Kapica-Topczewska; Katarzyna Socha; Jolanta Soroczyńska; Jacek Jamiołkowski; Alina Kułakowska; Jan Kochanowicz Journal: Nutrients Date: 2021-06-22 Impact factor: 5.717