Literature DB >> 29800654

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.

Jia-Qiang Huang1, Ji-Chang Zhou2, Yuan-Yuan Wu3, Fa-Zheng Ren1, Xin Gen Lei4.   

Abstract

Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. While past research explored regulations of gene expression and biochemical function of this selenoperoxidase, GPX1 has recently been implicated in the onset and development of chronic diseases. Clinical data have shown associations of human GPX1 gene variants with elevated risks of diabetes. Knockout and overexpression of Gpx1 in mice may induce types 1 and 2 diabetes-like phenotypes, respectively. This review assembles the latest advances in this new field of selenium biology, and attempts to postulate signal and molecular mechanisms mediating the role of GPX1 in glucose and lipid metabolism-related diseases. Potential therapies by harnessing the beneficial effects of this ubiquitous redox-modulating enzyme are briefly discussed.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Diabetes; Glucose; Glutathione peroxidase 1; Lipid; Selenium

Mesh：

Substances：

Year:  2018        PMID： 29800654      PMCID： PMC6168395          DOI： 10.1016/j.freeradbiomed.2018.05.077

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  125 in total

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3.  Reactive oxygen species as a signal in glucose-stimulated insulin secretion.

Authors:  Jingbo Pi; Yushi Bai; Qiang Zhang; Victoria Wong; Lisa M Floering; Kiefer Daniel; Jeffrey M Reece; Jude T Deeney; Melvin E Andersen; Barbara E Corkey; Sheila Collins
Journal:  Diabetes       Date:  2007-03-30       Impact factor: 9.461

4.  High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage.

Authors:  Troy L Merry; Melanie Tran; Maria Stathopoulos; Florian Wiede; Barbara Christianne Fam; Garron T Dodd; Iain Clarke; Matthew J Watt; Sofianos Andrikopoulos; Tony Tiganis
Journal:  Antioxid Redox Signal       Date:  2014-03-11       Impact factor: 8.401

5.  The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase.

Authors:  S Li; T Yan; J Q Yang; T D Oberley; L W Oberley
Journal:  Cancer Res       Date:  2000-07-15       Impact factor: 12.701

6.  Higher selenium status is associated with adverse blood lipid profile in British adults.

Authors:  Saverio Stranges; Martin Laclaustra; Chen Ji; Francesco P Cappuccio; Ana Navas-Acien; Jose M Ordovas; Margaret Rayman; Eliseo Guallar
Journal:  J Nutr       Date:  2009-11-11       Impact factor: 4.798

7.  Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of lebanese adults.

Authors:  Omar Obeid; Manal Elfakhani; Sani Hlais; Michel Iskandar; Malek Batal; Youssef Mouneimne; Nada Adra; Nahla Hwalla
Journal:  Biol Trace Elem Res       Date:  2008-02-21       Impact factor: 3.738

8.  Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.

Authors:  Phyllis Chew; Derek Y C Yuen; Nada Stefanovic; Josefa Pete; Melinda T Coughlan; Karin A Jandeleit-Dahm; Merlin C Thomas; Franklin Rosenfeldt; Mark E Cooper; Judy B de Haan
Journal:  Diabetes       Date:  2010-09-07       Impact factor: 9.461

9.  Molecular cloning of putative odorant-binding and odorant-metabolizing proteins.

Authors:  T N Dear; K Campbell; T H Rabbitts
Journal:  Biochemistry       Date:  1991-10-29       Impact factor: 3.162

Review 10.  Selenium and diabetes--evidence from animal studies.

Authors:  Jun Zhou; Kaixun Huang; Xin Gen Lei
Journal:  Free Radic Biol Med       Date:  2013-07-16       Impact factor: 7.376
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Journal:  Biol Trace Elem Res       Date:  2022-01-25       Impact factor: 3.738

Review 2.  Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction.

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Review 4.  The role of glutathione peroxidase-1 in health and disease.

Authors:  Diane E Handy; Joseph Loscalzo
Journal:  Free Radic Biol Med       Date:  2022-06-09       Impact factor: 8.101

Review 5.  Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology.

Authors:  Francesca Gorini; Cristina Vassalle
Journal:  Antioxidants (Basel)       Date:  2022-06-16

6.  Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?

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Journal:  Int J Mol Sci       Date:  2022-06-29       Impact factor: 6.208

7.  Hair Se Is a Sensitive Biomarker to Monitor the Effects of Se Supplementation in Elderly.

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Journal:  Biol Trace Elem Res       Date:  2021-03-18       Impact factor: 3.738

8.  Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.

Authors:  Swe Mar Oo; Hirofumi Misu; Yoshiro Saito; Mutsumi Tanaka; Seiji Kato; Yuki Kita; Hiroaki Takayama; Yumie Takeshita; Takehiro Kanamori; Toru Nagano; Masatoshi Nakagen; Takeshi Urabe; Naoto Matsuyama; Shuichi Kaneko; Toshinari Takamura
Journal:  Sci Rep       Date:  2018-11-13       Impact factor: 4.379

Review 9.  Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress.

Authors:  Xin Huang; Yu-Lan Dong; Tong Li; Wei Xiong; Xu Zhang; Peng-Jie Wang; Jia-Qiang Huang
Journal:  Nutrients       Date:  2021-05-01       Impact factor: 5.717

10.  Nicorandil decreases oxidative stress in slow- and fast-twitch muscle fibers of diabetic rats by improving the glutathione system functioning.

Authors:  Sarai Sánchez-Duarte; Sergio Márquez-Gamiño; Rocío Montoya-Pérez; Erick Andrés Villicaña-Gómez; Karla Susana Vera-Delgado; Cipriana Caudillo-Cisneros; Fernando Sotelo-Barroso; Ma Teresa Melchor-Moreno; Elizabeth Sánchez-Duarte
Journal:  J Diabetes Investig       Date:  2021-02-20       Impact factor: 4.232
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