Literature DB >> 25253891

Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt.

Mounir Georges AbouHaidar1, Srividhya Venkataraman2, Ashkan Golshani3, Bolin Liu2, Tauqeer Ahmad2.   

Abstract

The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid associated with rice yellow mottle virus codes for a 16-kDa highly basic protein using novel modalities for coding, translation, and gene expression. This CCC RNA is the smallest among all known viroids and virusoids and the only one that codes proteins. Its sequence possesses an internal ribosome entry site and is directly translated through two (or three) completely overlapping ORFs (shifting to a new reading frame at the end of each round). The initiation and termination codons overlap UGAUGA (underline highlights the initiation codon AUG within the combined initiation-termination sequence). Termination codons can be ignored to obtain larger read-through proteins. This circular RNA with no noncoding sequences is a unique natural supercompact "nanogenome."

Entities:  

Keywords:  circular RNA translation; hammerhead ribozyme; leaky termination codons; sobemovirus

Mesh：

Substances：

Year:  2014        PMID： 25253891      PMCID： PMC4209996          DOI： 10.1073/pnas.1402814111

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Inability of circular mRNA to attach to eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Nature       Date:  1979-07-05       Impact factor: 49.962

Review 2.  Small catalytic RNAs.

Authors:  R H Symons
Journal:  Annu Rev Biochem       Date:  1992       Impact factor: 23.643

3.  Overlapping genes in bacteriophage phiX174.

Authors:  B G Barrell; G M Air; C A Hutchison
Journal:  Nature       Date:  1976-11-04       Impact factor: 49.962

4.  In vitro messenger properties of a satellite RNA of cucumber mosaic virus.

Authors:  S Hidaka; K Hanada; K Ishikawa
Journal:  J Gen Virol       Date:  1990-02       Impact factor: 3.891

Review 5.  Replication of a plant virus satellite RNA: evidence favors transcription of circular templates of both polarities.

Authors:  G Bruening; B K Passmore; H van Tol; J M Buzayan; P A Feldstein
Journal:  Mol Plant Microbe Interact       Date:  1991 May-Jun       Impact factor: 4.171

6.  Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites.

Authors:  A C Forster; R H Symons
Journal:  Cell       Date:  1987-04-24       Impact factor: 41.582

Review 7.  A replication cycle for viroids and other small infectious RNA's.

Authors:  A D Branch; H D Robertson
Journal:  Science       Date:  1984-02-03       Impact factor: 47.728

Review 8.  Viroids.

Authors:  T O Diener
Journal:  Adv Virus Res       Date:  1983       Impact factor: 9.937

9.  Self-cleaving circular RNA associated with rice yellow mottle virus is the smallest viroid-like RNA.

Authors:  R F Collins; D L Gellatly; O P Sehgal; M G Abouhaidar
Journal:  Virology       Date:  1998-02-15       Impact factor: 3.616

10.  Expression of the coat protein of potato virus X from a dicistronic mRNA in transgenic potato plants.

Authors:  K L Hefferon; H Khalilian; H Xu; M G AbouHaidar
Journal:  J Gen Virol       Date:  1997-11       Impact factor: 3.891
View more
  67 in total

1.  Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.

Authors:  W Yang; W W Du; X Li; A J Yee; B B Yang
Journal:  Oncogene       Date:  2015-12-14       Impact factor: 9.867

2.  Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.

Authors:  Xinya Gao; Xin Xia; Fanying Li; Maolei Zhang; Huangkai Zhou; Xujia Wu; Jian Zhong; Zheng Zhao; Kun Zhao; Dawei Liu; Feizhe Xiao; Qiang Xu; Tao Jiang; Bo Li; Shi-Yuan Cheng; Nu Zhang
Journal:  Nat Cell Biol       Date:  2021-03-04       Impact factor: 28.824

Review 3.  Roles of Long Noncoding RNAs and Circular RNAs in Translation.

Authors:  Marina Chekulaeva; Nikolaus Rajewsky
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-06-03       Impact factor: 10.005

Review 4.  Progress in Understanding the Relationship Between Circular RNAs and Neurological Disorders.

Authors:  Qunhui Wang; Lai Qu; Xuan Chen; Yu-Hao Zhao; Qi Luo
Journal:  J Mol Neurosci       Date:  2018-08-01       Impact factor: 3.444

Review 5.  Circular RNAs in digestive system cancer: potential biomarkers and therapeutic targets.

Authors:  Jia-Qi Sheng; Lian Liu; Mu-Ru Wang; Pei-Yuan Li
Journal:  Am J Cancer Res       Date:  2018-07-01       Impact factor: 6.166

6.  A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.

Authors:  Qi Yang; William W Du; Nan Wu; Weining Yang; Faryal Mehwish Awan; Ling Fang; Jian Ma; Xiangmin Li; Yan Zeng; Zhenguo Yang; Jun Dong; Azam Khorshidi; Burton B Yang
Journal:  Cell Death Differ       Date:  2017-06-16       Impact factor: 15.828

Review 7.  Molecular interactions of plant viral satellites.

Authors:  Uzma Badar; Srividhya Venkataraman; Mounir AbouHaidar; Kathleen Hefferon
Journal:  Virus Genes       Date:  2020-11-23       Impact factor: 2.332

Review 8.  Circular RNAs in thoracic diseases.

Authors:  Fan Yang; Ping Zhu; Jintao Guo; Xiang Liu; Sheng Wang; Guoxin Wang; Wen Liu; Shupeng Wang; Nan Ge
Journal:  J Thorac Dis       Date:  2017-12       Impact factor: 2.895

9.  The integrative regulatory network of circRNA and microRNA in keloid scarring.

Authors:  Jingpei Shi; Shuluan Yao; Pan Chen; Yuan Yang; Mengjiao Qian; Yi Han; Nan Wang; Yu Zhao; Yongjing He; Lechun Lyu; Di Lu
Journal:  Mol Biol Rep       Date:  2019-10-14       Impact factor: 2.316

Review 10.  Emerging roles and context of circular RNAs.

Authors:  Amaresh C Panda; Ioannis Grammatikakis; Rachel Munk; Myriam Gorospe; Kotb Abdelmohsen
Journal:  Wiley Interdiscip Rev RNA       Date:  2016-09-09       Impact factor: 9.957
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.