The normal mode analysis shape detection method for automated shape determination of lung nodules.

Surface morphology and shape in general are important predictors for the behavior of solid-type lung nodules detected on CT. More broadly, shape analysis is useful in many areas of computer-aided diagnosis and essentially all scientific and engineering disciplines. Automated methods for shape detection have all previously, to the author's knowledge, relied on some sort of geometric measure. I introduce Normal Mode Analysis Shape Detection (NMA-SD), an approach that measures shape indirectly via the motion it would undergo if one imagined the shape to be a pseudomolecule. NMA-SD allows users to visualize internal movements in the imaging object and thereby develop an intuition for which motions are important, and which geometric features give rise to them. This can guide the identification of appropriate classification features to distinguish among classes of interest. I employ normal mode analysis (NMA) to animate pseudomolecules representing simulated lung nodules. Doing so, I am able to assign a testing set of nodules into the classes circular, elliptical, and irregular with roughly 97 % accuracy. This represents a proof-of-principle that one can obtain shape information by treating voxels as pseudoatoms in a pseudomolecule, and analyzing the pseudomolecule's predicted motion.