Literature DB >> 2522044

DNA analysis in juvenile Huntington disease.

M Schömig-Spingler1, J Hammer, K Kruse.   

Abstract

We report a 6-year-old boy with a positive family history of Huntington disease (HD), who presented with ambiguous neurological and psychiatric symptoms. The suspected diagnosis of HD was confirmed by DNA analysis. This new method is very helpful when the first signs of HD cannot be clearly interpreted.

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Year:  1989        PMID： 2522044     DOI： 10.1007/bf00595910

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  8 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Genetic prediction and family structure in Huntington's chorea.

Authors:  P S Harper; M Sarfarazi
Journal:  Br Med J (Clin Res Ed)       Date:  1985-06-29

3.  Hypervariable 'minisatellite' regions in human DNA.

Authors:  A J Jeffreys; V Wilson; S L Thein
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

Review 4.  Blot hybridisation analysis of genomic DNA.

Authors:  S Vandenplas; I Wiid; A Grobler-Rabie; K Brebner; M Ricketts; G Wållis; A Bester; C Boyd; C Måthew
Journal:  J Med Genet       Date:  1984-06       Impact factor: 6.318

5.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

6.  Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.

Authors:  T C Gilliam; R E Tanzi; J L Haines; T I Bonner; A G Faryniarz; W J Hobbs; M E MacDonald; S V Cheng; S E Folstein; P M Conneally
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

7.  A DNA segment encoding two genes very tightly linked to Huntington's disease.

Authors:  T C Gilliam; M Bucan; M E MacDonald; M Zimmer; J L Haines; S V Cheng; T M Pohl; R H Meyers; W L Whaley; B A Allitto
Journal:  Science       Date:  1987-11-13       Impact factor: 47.728

8.  A highly polymorphic locus very tightly linked to the Huntington's disease gene.

Authors:  J J Wasmuth; J Hewitt; B Smith; D Allard; J L Haines; D Skarecky; E Partlow; M R Hayden
Journal:  Nature       Date:  1988-04-21       Impact factor: 49.962
  8 in total
  1 in total

1.  DNA testing for Huntington disease results in a modification of risk and not diagnosis of disease.

Authors:  M Bloch; M R Hayden
Journal:  Eur J Pediatr       Date:  1990-04       Impact factor: 3.183
  1 in total

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