Adam C Naj1, Gyungah Jun2, Christiane Reitz3, Brian W Kunkle4, William Perry4, Yo Son Park5, Gary W Beecham6, Ruchita A Rajbhandary4, Kara L Hamilton-Nelson4, Li-San Wang7, John S K Kauwe8, Matthew J Huentelman9, Amanda J Myers10, Thomas D Bird11, Bradley F Boeve12, Clinton T Baldwin13, Gail P Jarvik14, Paul K Crane15, Ekaterina Rogaeva16, M Michael Barmada17, F Yesim Demirci17, Carlos Cruchaga18, Patricia L Kramer19, Nilufer Ertekin-Taner20, John Hardy21, Neill R Graff-Radford20, Robert C Green22, Eric B Larson23, Peter H St George-Hyslop24, Joseph D Buxbaum25, Denis A Evans26, Julie A Schneider27, Kathryn L Lunetta28, M Ilyas Kamboh29, Andrew J Saykin30, Eric M Reiman31, Philip L De Jager32, David A Bennett33, John C Morris34, Thomas J Montine35, Alison M Goate18, Deborah Blacker36, Debby W Tsuang37, Hakon Hakonarson38, Walter A Kukull39, Tatiana M Foroud40, Eden R Martin6, Jonathan L Haines41, Richard P Mayeux42, Lindsay A Farrer43, Gerard D Schellenberg7, Margaret A Pericak-Vance6, Marilyn S Albert44, Roger L Albin45, Liana G Apostolova46, Steven E Arnold47, Robert Barber48, Lisa L Barnes49, Thomas G Beach50, James T Becker51, Duane Beekly52, Eileen H Bigio53, James D Bowen54, Adam Boxer55, James R Burke56, Nigel J Cairns57, Laura B Cantwell7, Chuanhai Cao58, Chris S Carlson59, Regina M Carney10, Minerva M Carrasquillo60, Steven L Carroll61, Helena C Chui62, David G Clark63, Jason Corneveaux9, David H Cribbs64, Elizabeth A Crocco10, Charles DeCarli65, Steven T DeKosky66, Malcolm Dick67, Dennis W Dickson60, Ranjan Duara68, Kelley M Faber40, Kenneth B Fallon61, Martin R Farlow69, Steven Ferris70, Matthew P Frosch71, Douglas R Galasko72, Mary Ganguli73, Marla Gearing74, Daniel H Geschwind75, Bernardino Ghetti76, John R Gilbert6, Jonathan D Glass77, John H Growdon78, Ronald L Hamilton79, Lindy E Harrell63, Elizabeth Head80, Lawrence S Honig81, Christine M Hulette82, Bradley T Hyman78, Gregory A Jicha83, Lee-Way Jin84, Anna Karydas55, Jeffrey A Kaye85, Ronald Kim86, Edward H Koo72, Neil W Kowall87, Joel H Kramer88, Frank M LaFerla89, James J Lah77, James B Leverenz35, Allan I Levey77, Ge Li90, Andrew P Lieberman91, Chiao-Feng Lin7, Oscar L Lopez92, Constantine G Lyketsos93, Wendy J Mack94, Frank Martiniuk95, Deborah C Mash96, Eliezer Masliah97, Wayne C McCormick15, Susan M McCurry98, Andrew N McDavid59, Ann C McKee87, Marsel Mesulam99, Bruce L Miller55, Carol A Miller100, Joshua W Miller84, Jill R Murrell101, John M Olichney65, Vernon S Pankratz102, Joseph E Parisi103, Henry L Paulson104, Elaine Peskind90, Ronald C Petersen12, Aimee Pierce64, Wayne W Poon67, Huntington Potter58, Joseph F Quinn105, Ashok Raj58, Murray Raskind90, Barry Reisberg106, John M Ringman46, Erik D Roberson63, Howard J Rosen55, Roger N Rosenberg107, Mary Sano108, Lon S Schneider109, William W Seeley55, Amanda G Smith58, Joshua A Sonnen35, Salvatore Spina76, Robert A Stern110, Rudolph E Tanzi78, Tricia A Thornton-Wells111, John Q Trojanowski7, Juan C Troncoso112, Otto Valladares7, Vivianna M Van Deerlin7, Linda J Van Eldik113, Badri N Vardarajan114, Harry V Vinters115, Jean Paul Vonsattel116, Sandra Weintraub117, Kathleen A Welsh-Bohmer118, Jennifer Williamson81, Sarah Wishnek4, Randall L Woltjer119, Clinton B Wright120, Steven G Younkin60, Chang-En Yu15, Lei Yu121. 1. Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia. 2. Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts. 3. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York7Gertrude H. Sergievsky Center, Columbia University, New York, New York8Department of Neurology, Columbia University, New York, New. 4. John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida. 5. The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida. 6. John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida. 7. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia. 8. Department of Biology, Brigham Young University, Provo, Utah. 9. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona. 10. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida. 11. Department of Neurology, University of Washington, Seattle15Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington. 12. Department of Neurology, Mayo Clinic, Rochester, Minnesota. 13. Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts. 14. Department of Genome Sciences, University of Washington, Seattle18Division of Medical Genetics, Department of Medicine, University of Washington, Seattle. 15. Department of Medicine, University of Washington, Seattle. 16. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. 17. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania. 18. Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri. 19. Department of Neurology, Oregon Health & Science University, Portland24Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland. 20. Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida. 21. Institute of Neurology, University College London, London, England. 22. Division of Genetics, Department of Medicine, and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. 23. Department of Medicine, University of Washington, Seattle29Group Health Research Institute, Group Health Cooperative, Seattle, Washington. 24. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada30Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, England. 25. Department of Neuroscience, Mount Sinai School of Medicine, New York, New York32Department of Psychiatry, Mount Sinai School of Medicine, New York, New York33Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York. 26. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois. 27. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois36Neuropathology, Department of Pathology, Rush University Medical Center, Chicago, Illinois. 28. Department of Biostatistics, Boston University, Boston, Massachusetts. 29. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania37Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania. 30. Department of Medical and Molecular Genetics, Indiana University, Indianapolis39Department of Radiology and Imaging Sciences, Indiana University, Indianapolis. 31. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona40Arizona Alzheimer's Consortium, Phoenix41Department of Psychiatry, University of Arizona, Phoenix42Banner Alzheimer's Institute, Phoenix, Arizona. 32. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts44Program in Medical and Population Genetics, Broad Ins. 33. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois45Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois. 34. Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri47Department of Neurology, Washington University in St Louis, St Louis, Missouri. 35. Department of Pathology, University of Washington, Seattle. 36. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts50Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston. 37. Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington51Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle. 38. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. 39. Department of Epidemiology, University of Washington, Seattle. 40. Department of Medical and Molecular Genetics, Indiana University, Indianapolis. 41. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee55Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee. 42. Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York57Gertrude H. Sergievsky Center, Columbia University, New York, New York58Department of Neurology, Columbia University, New York, New York. 43. Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts59Department of Epidemiology, Bos. 44. Department of Neurology, Johns Hopkins University, Baltimore, Maryland. 45. Department of Neurology, University of Michigan, Ann Arbor63Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan64Michigan Alzheimer Disease Center, Ann Arbor. 46. Department of Neurology, University of California Los Angeles, Los Angeles. 47. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia. 48. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth. 49. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois68Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois. 50. Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona. 51. Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 52. National Alzheimer's Coordinating Center, University of Washington, Seattle. 53. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois73Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois. 54. Swedish Medical Center, Seattle, Washington. 55. Department of Neurology, University of California San Francisco, San Francisco. 56. Department of Medicine, Duke University, Durham, North Carolina. 57. Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri. 58. USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa. 59. Fred Hutchinson Cancer Research Center, Seattle, Washington. 60. Department of Neuroscience, Mayo Clinic, Jacksonville, Florida. 61. Department of Pathology, University of Alabama at Birmingham, Birmingham. 62. Department of Neurology, University of Southern California, Los Angeles. 63. Department of Neurology, University of Alabama at Birmingham, Birmingham. 64. Department of Neurology, University of California Irvine, Irvine. 65. Department of Neurology, University of California Davis, Sacramento. 66. University of Virginia School of Medicine, Charlottesville. 67. Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine. 68. Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida. 69. Department of Neurology, Indiana University, Indianapolis. 70. Department of Psychiatry, New York University, New York. 71. C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown. 72. Department of Neurosciences, University of California San Diego, La Jolla. 73. Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. 74. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia93Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia. 75. Neurogenetics Program, University of California Los Angeles, Los Angeles. 76. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis. 77. Department of Neurology, Emory University, Atlanta, Georgia. 78. Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston. 79. Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania. 80. Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington. 81. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York. 82. Department of Pathology, Duke University, Durham, North Carolina. 83. Sanders-Brown Center on Aging, Department Neurology, University of Kentucky, Lexington. 84. Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento. 85. Department of Neurology, Oregon Health & Science University, Portland103Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon. 86. Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine. 87. Department of Neurology, Boston University, Boston, Massachusetts105Department of Pathology, Boston University, Boston, Massachusetts. 88. Department of Neuropsychology, University of California San Francisco, San Francisco. 89. Department of Neurobiology and Behavior, University of California Irvine, Irvine. 90. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle. 91. Department of Pathology, University of Michigan, Ann Arbor. 92. Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania. 93. Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland. 94. Department of Preventive Medicine, University of Southern California, Los Angeles. 95. Department of Medicine - Pulmonary, New York University, New York. 96. Department of Neurology, University of Miami, Miami, Florida. 97. Department of Neurosciences, University of California San Diego, La Jolla113Department of Pathology, University of California San Diego, La Jolla. 98. School of Nursing Northwest Research Group on Aging, University of Washington, Seattle. 99. Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois115Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 100. Department of Pathology, University of Southern California, Los Angeles. 101. Department of Medical and Molecular Genetics, Indiana University, Indianapolis95Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis. 102. Department of Biostatistics, Mayo Clinic, Rochester, Minnesota. 103. Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota119Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. 104. Department of Neurology, University of Michigan, Ann Arbor. 105. Department of Neurology, Oregon Health & Science University, Portland. 106. Department of Psychiatry, New York University, New York120Alzheimer's Disease Center, New York University, New York. 107. Department of Neurology, University of Texas Southwestern, Dallas. 108. Department of Psychiatry, Mount Sinai School of Medicine, New York, New York. 109. Department of Neurology, University of Southern California, Los Angeles122Department of Psychiatry, University of Southern California, Los Angeles. 110. Department of Neurology, Boston University, Boston, Massachusetts. 111. Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee. 112. Department of Pathology, Johns Hopkins University, Baltimore, Maryland. 113. Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington. 114. Department of Neurology, Columbia University, New York, New York. 115. Department of Neurology, University of California Los Angeles, Los Angeles125Department of Pathology & Laboratory Medicine, University of California Los Angeles, Los Angeles. 116. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York. 117. Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois127Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 118. Department of Medicine, Duke University, Durham, North Carolina128Department of Psychiatry & Behavioral Sciences, Duke University, Durham, North Carolina. 119. Department of Pathology, Oregon Health & Science University, Portland. 120. Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida. 121. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.
Abstract
IMPORTANCE: Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants. OBJECTIVES: To investigate the effects of known Alzheimer disease risk loci in modifying AAO and to estimate their cumulative effect on AAO variation using data from genome-wide association studies in the Alzheimer Disease Genetics Consortium. DESIGN, SETTING, AND PARTICIPANTS: The Alzheimer Disease Genetics Consortium comprises 14 case-control, prospective, and family-based data sets with data on 9162 participants of white race/ethnicity with Alzheimer disease occurring after age 60 years who also had complete AAO information, gathered between 1989 and 2011 at multiple sites by participating studies. Data on genotyped or imputed single-nucleotide polymorphisms most significantly associated with risk at 10 confirmed LOAD loci were examined in linear modeling of AAO, and individual data set results were combined using a random-effects, inverse variance-weighted meta-analysis approach to determine whether they contribute to variation in AAO. Aggregate effects of all risk loci on AAO were examined in a burden analysis using genotype scores weighted by risk effect sizes. MAIN OUTCOMES AND MEASURES: Age at disease onset abstracted from medical records among participants with LOAD diagnosed per standard criteria. RESULTS: Analysis confirmed the association of APOE with earlier AAO (P = 3.3 × 10(-96)), with associations in CR1 (rs6701713, P = 7.2 × 10(-4)), BIN1 (rs7561528, P = 4.8 × 10(-4)), and PICALM (rs561655, P = 2.2 × 10(-3)) reaching statistical significance (P < .005). Risk alleles individually reduced AAO by 3 to 6 months. Burden analyses demonstrated that APOE contributes to 3.7% of the variation in AAO (R(2) = 0.256) over baseline (R(2) = 0.221), whereas the other 9 loci together contribute to 2.2% of the variation (R(2) = 0.242). CONCLUSIONS AND RELEVANCE: We confirmed an association of APOE (OMIM 107741) variants with AAO among affected participants with LOAD and observed novel associations of CR1 (OMIM 120620), BIN1 (OMIM 601248), and PICALM (OMIM 603025) with AAO. In contrast to earlier hypothetical modeling, we show that the combined effects of Alzheimer disease risk variants on AAO are on the scale of, but do not exceed, the APOE effect. While the aggregate effects of risk loci on AAO may be significant, additional genetic contributions to AAO are individually likely to be small.
IMPORTANCE: Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants. OBJECTIVES: To investigate the effects of known Alzheimer disease risk loci in modifying AAO and to estimate their cumulative effect on AAO variation using data from genome-wide association studies in the Alzheimer Disease Genetics Consortium. DESIGN, SETTING, AND PARTICIPANTS: The Alzheimer Disease Genetics Consortium comprises 14 case-control, prospective, and family-based data sets with data on 9162 participants of white race/ethnicity with Alzheimer disease occurring after age 60 years who also had complete AAO information, gathered between 1989 and 2011 at multiple sites by participating studies. Data on genotyped or imputed single-nucleotide polymorphisms most significantly associated with risk at 10 confirmed LOAD loci were examined in linear modeling of AAO, and individual data set results were combined using a random-effects, inverse variance-weighted meta-analysis approach to determine whether they contribute to variation in AAO. Aggregate effects of all risk loci on AAO were examined in a burden analysis using genotype scores weighted by risk effect sizes. MAIN OUTCOMES AND MEASURES: Age at disease onset abstracted from medical records among participants with LOAD diagnosed per standard criteria. RESULTS: Analysis confirmed the association of APOE with earlier AAO (P = 3.3 × 10(-96)), with associations in CR1 (rs6701713, P = 7.2 × 10(-4)), BIN1 (rs7561528, P = 4.8 × 10(-4)), and PICALM (rs561655, P = 2.2 × 10(-3)) reaching statistical significance (P < .005). Risk alleles individually reduced AAO by 3 to 6 months. Burden analyses demonstrated that APOE contributes to 3.7% of the variation in AAO (R(2) = 0.256) over baseline (R(2) = 0.221), whereas the other 9 loci together contribute to 2.2% of the variation (R(2) = 0.242). CONCLUSIONS AND RELEVANCE: We confirmed an association of APOE (OMIM 107741) variants with AAO among affected participants with LOAD and observed novel associations of CR1 (OMIM 120620), BIN1 (OMIM 601248), and PICALM (OMIM 603025) with AAO. In contrast to earlier hypothetical modeling, we show that the combined effects of Alzheimer disease risk variants on AAO are on the scale of, but do not exceed, the APOE effect. While the aggregate effects of risk loci on AAO may be significant, additional genetic contributions to AAO are individually likely to be small.
Authors: Peter Holmans; Marian Hamshere; Paul Hollingworth; Frances Rice; Nigel Tunstall; Sue Jones; Pamela Moore; Fabienne Wavrant DeVrieze; Amanda Myers; Richard Crook; Danielle Compton; Helen Marshall; David Meyer; Shantia Shears; Jeremy Booth; Dzanan Ramic; Nigel Williams; Nadine Norton; Richard Abraham; Pat Kehoe; Hywel Williams; Varuni Rudrasingham; Mick O'Donovan; Lesley Jones; John Hardy; Alison Goate; Simon Lovestone; Michael Owen; Julie Williams Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2005-05-05 Impact factor: 3.568
Authors: Yoonha Choi; Elizabeth E Marchani; Thomas D Bird; Ellen J Steinbart; Deborah Blacker; Ellen M Wijsman Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2011-08-02 Impact factor: 3.568
Authors: D A Evans; H H Funkenstein; M S Albert; P A Scherr; N R Cook; M J Chown; L E Hebert; C H Hennekens; J O Taylor Journal: JAMA Date: 1989-11-10 Impact factor: 56.272
Authors: E H Corder; A M Saunders; W J Strittmatter; D E Schmechel; P C Gaskell; G W Small; A D Roses; J L Haines; M A Pericak-Vance Journal: Science Date: 1993-08-13 Impact factor: 47.728
Authors: Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg Journal: Nat Genet Date: 2011-04-03 Impact factor: 38.330
Authors: Paul Hollingworth; Denise Harold; Rebecca Sims; Amy Gerrish; Jean-Charles Lambert; Minerva M Carrasquillo; Richard Abraham; Marian L Hamshere; Jaspreet Singh Pahwa; Valentina Moskvina; Kimberley Dowzell; Nicola Jones; Alexandra Stretton; Charlene Thomas; Alex Richards; Dobril Ivanov; Caroline Widdowson; Jade Chapman; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; David Mann; A David Smith; Helen Beaumont; Donald Warden; Gordon Wilcock; Seth Love; Patrick G Kehoe; Nigel M Hooper; Emma R L C Vardy; John Hardy; Simon Mead; Nick C Fox; Martin Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Eckart Rüther; Britta Schürmann; Reiner Heun; Heike Kölsch; Hendrik van den Bussche; Isabella Heuser; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Frölich; Harald Hampel; John Gallacher; Michael Hüll; Dan Rujescu; Ina Giegling; Alison M Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John C Morris; Kevin Mayo; Kristel Sleegers; Karolien Bettens; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Gill Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panagiotis Deloukas; Ammar Al-Chalabi; Christopher E Shaw; Magda Tsolaki; Andrew B Singleton; Rita Guerreiro; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H-Erich Wichmann; V Shane Pankratz; Sigrid B Sando; Jan O Aasly; Maria Barcikowska; Zbigniew K Wszolek; Dennis W Dickson; Neill R Graff-Radford; Ronald C Petersen; Cornelia M van Duijn; Monique M B Breteler; M Arfan Ikram; Anita L DeStefano; Annette L Fitzpatrick; Oscar Lopez; Lenore J Launer; Sudha Seshadri; Claudine Berr; Dominique Campion; Jacques Epelbaum; Jean-François Dartigues; Christophe Tzourio; Annick Alpérovitch; Mark Lathrop; Thomas M Feulner; Patricia Friedrich; Caterina Riehle; Michael Krawczak; Stefan Schreiber; Manuel Mayhaus; S Nicolhaus; Stefan Wagenpfeil; Stacy Steinberg; Hreinn Stefansson; Kari Stefansson; Jon Snaedal; Sigurbjörn Björnsson; Palmi V Jonsson; Vincent Chouraki; Benjamin Genier-Boley; Mikko Hiltunen; Hilkka Soininen; Onofre Combarros; Diana Zelenika; Marc Delepine; Maria J Bullido; Florence Pasquier; Ignacio Mateo; Ana Frank-Garcia; Elisa Porcellini; Olivier Hanon; Eliecer Coto; Victoria Alvarez; Paolo Bosco; Gabriele Siciliano; Michelangelo Mancuso; Francesco Panza; Vincenzo Solfrizzi; Benedetta Nacmias; Sandro Sorbi; Paola Bossù; Paola Piccardi; Beatrice Arosio; Giorgio Annoni; Davide Seripa; Alberto Pilotto; Elio Scarpini; Daniela Galimberti; Alexis Brice; Didier Hannequin; Federico Licastro; Lesley Jones; Peter A Holmans; Thorlakur Jonsson; Matthias Riemenschneider; Kevin Morgan; Steven G Younkin; Michael J Owen; Michael O'Donovan; Philippe Amouyel; Julie Williams Journal: Nat Genet Date: 2011-04-03 Impact factor: 38.330
Authors: Christian LoBue; Hannah Wadsworth; Kristin Wilmoth; Matthew Clem; John Hart; Kyle B Womack; Nyaz Didehbani; Laura H Lacritz; Heidi C Rossetti; C Munro Cullum Journal: Clin Neuropsychol Date: 2016-11-18 Impact factor: 3.535
Authors: Vincent Chouraki; Christiane Reitz; Fleur Maury; Joshua C Bis; Celine Bellenguez; Lei Yu; Johanna Jakobsdottir; Shubhabrata Mukherjee; Hieab H Adams; Seung Hoan Choi; Eric B Larson; Annette Fitzpatrick; Andre G Uitterlinden; Philip L de Jager; Albert Hofman; Vilmundur Gudnason; Badri Vardarajan; Carla Ibrahim-Verbaas; Sven J van der Lee; Oscar Lopez; Jean-François Dartigues; Claudine Berr; Philippe Amouyel; David A Bennett; Cornelia van Duijn; Anita L DeStefano; Lenore J Launer; M Arfan Ikram; Paul K Crane; Jean-Charles Lambert; Richard Mayeux; Sudha Seshadri Journal: J Alzheimers Dis Date: 2016-06-18 Impact factor: 4.472