BACKGROUND: The relationship between the apolipoprotein E (ApoE) genotype and the risk for developing Alzheimer's disease (AD) or age at onset of AD is relatively well established in Caucasians, but less established in other ethnicities. We examined the association between the ApoE genotype and age at onset of AD in a quadriethnic group of community-dwelling AD patients. METHODS: AD patients were evaluated at 2 university-based outpatient memory disorder clinics. The ethnic distribution was as follows: Caucasians (n = 1,083), Hispanics (n = 55), African Americans (n = 84) and Koreans (n = 87). All were diagnosed with probable AD according to NINCDS-ADRDA diagnostic criteria. RESULTS: After adjusting for ethnicity, the ε4 allele was significantly associated with earlier age at onset (p < 0.0001) for the combined group. Within ethnic groups, the effect of Apo ε4 on age at onset was significant in Caucasians (p < 0.0001) and African Americans (p < 0.05), but nonsignificant in Koreans (p = 0.43) and in the smaller Hispanic (p = 0.07) group. CONCLUSIONS: The association between Apo ε4 and younger age at onset was significant in Caucasians and African Americans, where the ε4 allele was also most frequent. This study suggests that the impact of ApoE polymorphism on age at onset of AD may be different among distinct ethnic groups.
BACKGROUND: The relationship between the apolipoprotein E (ApoE) genotype and the risk for developing Alzheimer's disease (AD) or age at onset of AD is relatively well established in Caucasians, but less established in other ethnicities. We examined the association between the ApoE genotype and age at onset of AD in a quadriethnic group of community-dwelling ADpatients. METHODS:ADpatients were evaluated at 2 university-based outpatientmemory disorder clinics. The ethnic distribution was as follows: Caucasians (n = 1,083), Hispanics (n = 55), African Americans (n = 84) and Koreans (n = 87). All were diagnosed with probable AD according to NINCDS-ADRDA diagnostic criteria. RESULTS: After adjusting for ethnicity, the ε4 allele was significantly associated with earlier age at onset (p < 0.0001) for the combined group. Within ethnic groups, the effect of Apo ε4 on age at onset was significant in Caucasians (p < 0.0001) and African Americans (p < 0.05), but nonsignificant in Koreans (p = 0.43) and in the smaller Hispanic (p = 0.07) group. CONCLUSIONS: The association between Apo ε4 and younger age at onset was significant in Caucasians and African Americans, where the ε4 allele was also most frequent. This study suggests that the impact of ApoE polymorphism on age at onset of AD may be different among distinct ethnic groups.
Authors: Joy L Taylor; Blake K Scanlon; Michelle Farrell; Beatriz Hernandez; Maheen M Adamson; J Wesson Ashford; Art Noda; Greer M Murphy; Michael W Weiner Journal: Neurobiol Aging Date: 2014-05-15 Impact factor: 4.673
Authors: Astrid Suchy-Dicey; Barbara Howard; W T Longstreth; Eric M Reiman; Dedra Buchwald Journal: Alzheimers Dement Date: 2022-02-10 Impact factor: 16.655
Authors: L Jaime Fitten; Freddy Ortiz; Lynn Fairbanks; George Bartzokis; Po Lu; Eric Klein; Giovanni Coppola; John Ringman Journal: Int J Geriatr Psychiatry Date: 2014-01-29 Impact factor: 3.485
Authors: Brian J Piper; Alia L Yasen; Amy E Taylor; Jonatan R Ruiz; J William Gaynor; Catherine A Dayger; Marcela Gonzalez-Gross; Oh D Kwon; Lars-Göran Nilsson; Ian N M Day; Jacob Raber; Jeremy K Miller Journal: Laterality Date: 2012-06-21
Authors: Adam C Naj; Gyungah Jun; Christiane Reitz; Brian W Kunkle; William Perry; Yo Son Park; Gary W Beecham; Ruchita A Rajbhandary; Kara L Hamilton-Nelson; Li-San Wang; John S K Kauwe; Matthew J Huentelman; Amanda J Myers; Thomas D Bird; Bradley F Boeve; Clinton T Baldwin; Gail P Jarvik; Paul K Crane; Ekaterina Rogaeva; M Michael Barmada; F Yesim Demirci; Carlos Cruchaga; Patricia L Kramer; Nilufer Ertekin-Taner; John Hardy; Neill R Graff-Radford; Robert C Green; Eric B Larson; Peter H St George-Hyslop; Joseph D Buxbaum; Denis A Evans; Julie A Schneider; Kathryn L Lunetta; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; Philip L De Jager; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Eden R Martin; Jonathan L Haines; Richard P Mayeux; Lindsay A Farrer; Gerard D Schellenberg; Margaret A Pericak-Vance; Marilyn S Albert; Roger L Albin; Liana G Apostolova; Steven E Arnold; Robert Barber; Lisa L Barnes; Thomas G Beach; James T Becker; Duane Beekly; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Laura B Cantwell; Chuanhai Cao; Chris S Carlson; Regina M Carney; Minerva M Carrasquillo; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; David H Cribbs; Elizabeth A Crocco; Charles DeCarli; Steven T DeKosky; Malcolm Dick; Dennis W Dickson; Ranjan Duara; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; Joel H Kramer; Frank M LaFerla; James J Lah; James B Leverenz; Allan I Levey; Ge Li; Andrew P Lieberman; Chiao-Feng Lin; Oscar L Lopez; Constantine G Lyketsos; Wendy J Mack; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Jill R Murrell; John M Olichney; Vernon S Pankratz; Joseph E Parisi; Henry L Paulson; Elaine Peskind; Ronald C Petersen; Aimee Pierce; Wayne W Poon; Huntington Potter; Joseph F Quinn; Ashok Raj; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Howard J Rosen; Roger N Rosenberg; Mary Sano; Lon S Schneider; William W Seeley; Amanda G Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; Tricia A Thornton-Wells; John Q Trojanowski; Juan C Troncoso; Otto Valladares; Vivianna M Van Deerlin; Linda J Van Eldik; Badri N Vardarajan; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Sarah Wishnek; Randall L Woltjer; Clinton B Wright; Steven G Younkin; Chang-En Yu; Lei Yu Journal: JAMA Neurol Date: 2014-11 Impact factor: 18.302